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排序方式: 共有265条查询结果,搜索用时 15 毫秒
71.
72.
RS Jagavkar TP Shakespeare MJ Stevens 《Journal of Medical Imaging and Radiation Oncology》1998,42(2):157-158
The first documented case of endometrial adenosarcoma associated with chronic tamoxifen usage is reported. 相似文献
73.
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer 总被引:8,自引:2,他引:6
Ylikorkala A; Avizienyte E; Tomlinson IP; Tiainen M; Roth S; Loukola A; Hemminki A; Johansson M; Sistonen P; Markie D; Neale K; Phillips R; Zauber P; Twama T; Sampson J; Jarvinen H; Makela TP; Aaltonen LA 《Human molecular genetics》1999,8(1):45-51
Germline mutations in LKB1 have been reported to underlie familial
Peutz-Jeghers syndrome (PJS) with intestinal hamartomatous polyps and an
elevated risk of various neoplasms. To investigate the prevalence of LKB1
germline mutations in PJS more generally, we studied samples from 33
unrelated PJS patients including eight non-familial sporadic patients, 20
familial patients and five patients with unknown family history. Nineteen
germline mutations were identified, 12 (60%) in familial and four (50%) in
sporadic cases. LKB1 mutations were not detected in 14 (42%) patients,
indicating that the existence of additional minor PJS loci cannot be
excluded. LKB1 is predicted to encode a serine/threonine kinase. To
demonstrate the putative Lkb1 kinase function and to study the consequences
of LKB1 mutations in PJS and sporadic tumors, we have analyzed the kinase
activity of wild-type and mutant Lkb1 proteins. Interestingly, while most
of the small deletions or missense mutations resulted in loss-of-function
alleles, one missense mutation (G163D) previously identified in a sporadic
testicular tumor demonstrated severely impaired but detectable kinase
activity.
相似文献
74.
To investigate the membrane abnormalities that may play a pathophysiologic role in several hemolytic anemias we determined the density distribution on sucrose density gradients of human red blood cell (RBC) membranes from patients with these disorders, from normal controls, and from incubated normal RBC. We analyzed the fractions for membrane-adsorbed hemoglobin (Hb), globin, and nonglobin cytoplasmic proteins. The relationship between the cytoplasmic proteins adsorbed on the membranes and the specific gravity (SG) of the membranes was linear. An increase in SG of the entire membrane population was seen in Hb C disease due to adsorbed Hb. Subpopulations of membranes with increased SG due to adsorption of nonglobin protein were evident in the membranes from two splenectomized patients with hemolytic glucose-6- phosphate dehydrogenase (G6PD) variants. Dense membrane subpopulations found in RBC membranes from three splenectomized patients with Hb Koln were associated with adsorbed globin, while similar subpopulations in RBC membranes from three splenectomized patients with hereditary spherocytosis demonstrated increased SG due to adsorbed Hb. Splenectomized normals had no such abnormality in membrane density. Sucrose density gradients demonstrate that membrane bound cytoplasmic protein is characteristic of the RBC membranes in several hemolytic disorders. Additionally, gradients are useful for the isolation and further analysis of those subpopulations of RBC membranes with abnormal SG and exaggerated membrane protein abnormalities. 相似文献
75.
76.
Supratentorial ependymoma: CT appearance 总被引:5,自引:0,他引:5
Armington WG; Osborn AG; Cubberley DA; Harnsberger HR; Boyer R; Naidich TP; Sherry RG 《Radiology》1985,157(2):367-372
The computed tomographic appearances of 22 biopsy-proved supratentorial ependymomas were analyzed. Supratentorial ependymomas were usually intraparenchymal, larger than 4 cm, and cystic. Contrast enhancement was moderate to intense, with homogeneous or ring-enhancement patterns commonly seen. Intratumoral calcification was present in one-third of the cases, while hydrocephalus and peritumoral edema were seen in 50%. Intratumoral hemorrhage was not a characteristic of the lesion. In contrast to cellular ependymomas, malignant ependymomas and ependymoblastomas demonstrate higher attenuation prior to administration of contrast material, more intense enhancement, lower frequency of calcification within the tumor, and less distinct margination. 相似文献
77.
JI Tang TP Shakespeare JJ Lu YH Chan KM Lee LC Wong RK Mukherjee MF Back 《Journal of Medical Imaging and Radiation Oncology》2008,52(5):497-502
The palliative radiotherapeutic management of unresectable non‐small‐cell lung cancer is controversial, with various fractionation (Fx) schedules available. We aimed to determine patient’s choice of Fx schedule after involvement in a decision‐making process using a decision board. A decision board outlining the various advantages and disadvantages apparent in the Medical Research Council study of Fx schedules (17 Gy in two fractions vs 39 Gy in 13 fractions) was discussed with patients who met Medical Research Council eligibility criteria. Patients were then asked to indicate their preferred Fx schedules, reasons and their level of satisfaction with being involved in the decision‐making process. Radiation oncologists (RO) could prescribe radiotherapy schedules irrespective of patients’ preferences. Of 92 patients enrolled, 55% chose the longer schedule. English‐speaking patients were significantly more likely to choose the longer schedule (P = 0.02, 95% confidence interval: 1.2–7.6). Longer Fx was chosen because of longer survival (90%) and better local control (12%). Shorter Fx was chosen for shorter overall treatment duration (80%), cost (61%) and better symptom control (20%). In all, 56% of patients choosing the shorter schedule had their treatment altered by the treating RO, whereas only 4% of patients choosing longer Fx had their treatment altered (P < 0.001). Despite this, all (100%) patients were satisfied with being involved in the decision‐making process. The decision board was useful in aiding decision‐making, with both Fx schedules being acceptable to patients. Interestingly, despite the longer average survival associated with longer Fx, nearly half of the patients believed that this was not as important as a shorter duration of treatment and lower cost. Despite patients’ preferences, there were significant alterations of preferred schedules because of RO’s own biases. 相似文献
78.
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