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Nicola Crea Giacomo Pata Ernesto Di Betta Amin Titi Francesco Mittempergher 《Obesity surgery》2011,21(2):151-156
Although the appendix has been recognized as a preferential site for carcinoid tumors in obese patients, no definitive guidelines
are so far available regarding the management of these patients when candidates for bariatric surgery. This study was designed
to fill that gap. Between 2000-2008, 558 patients underwent bariatric procedures. Appendectomy was routinely performed in
477 cases. Their charts were retrospectively retrieved and histopathology responses on surgical specimens were recorded. We
aimed to assess: incidence of appendix carcinoid tumors (ACTs) and any possible risk-factor; modality of diagnosis (pre-,
intra- or post-operatively); impact on the planned bariatric procedure; treatment reserved to such cases. Typical ACTs were
diagnosed in 7 patients (1.4%) (median age: 33 years; median BMI: 49 kg/m2; males/females: 1/6). Four were diagnosed intra-operatively.
Because of dimensions (<2 cm) and absence of mesoappendiceal or serosal involvement, simple appendectomy was performed during
bariatric procedure, as planned. Three were diagnosed post-operatively (all <2 cm). In 1 case right hemicolectomy was performed
1 month later due to mesoappendiceal involvement. No appendectomy-related complication was encountered. All patients remained
tumor-free during follow-up (mean: 64 months; range, 25-92). Young age, female sex, high BMI and diabetes mellitus resulted
significantly associated with ACT. Our study sustains routine appendectomy or at least careful investigation of the appendix
during bariatric surgery. For tumors <2 cm without mesoappendiceal or serosal involvement, simple appendectomy proved sufficient.
Bariatric surgery did not have a negative effect on the treatment of malignancies that are discovered intra- or post-operatively. 相似文献
994.
G. Marruchella C. Ligios M. Baffoni M. G. Cancedda F. Demontis G. Donatucci R. Chiocchetti P. Clavenzani G. Lalatta-Costerbosa G. Di Guardo 《Archives of virology》2009,154(4):709-714
Ileal Peyer’s patches (PPs) are involved early during sheep scrapie infection. This study qualitatively and semi-quantitatively
evaluated ileal tract and PP innervation in 29 Sarda ovines of different age, PrP genotype and scrapie status. A prominent
network of fibres was detected within PPs, mainly located in interfollicular lymphoid and stromal components. Intrafollicular
fibres were rarely observed, with no apparent differences between scrapie-free and scrapie-affected animals, or among ovines
carrying different PrP genotypes. In adult sheep, independent of their scrapie status, nerve fibres could be detected infrequently,
close to the follicle-associated epithelium. Fibres were also detected within newly formed follicles and intrafollicular microgranulomas. 相似文献
995.
Cláudio de Góis Nery Fernando Stefanato Buranello Cícero Pereira Renata Cantisani Di Francesco 《Revista brasileira de otorrinolaringologia (English ed.)》2011,77(1):84-87
Abnormalities in craniofacial morphology are associated with Eustachian tube dysfunction and otitis media with effusion (OME).Aim: to evaluate the relationship between facial pattern and craniofacial growth direction, and OME in children with enlarged tonsils and adenoids (ETA).Methods: Clinical prospective survey in 79 children (41 male and 38 female), ranging from 4 to 10 years of age, with tonsil and adenoid enlargement (Brodsky's grades III and IV). Forty children presented with OME (study group) and 39 did not (control group). Cephalometric analysis was used to determine the facial pattern.Results: There was no correlation observed between facial pattern and OME (c 2 = 0.25 p = 0.88). Facial Axis was larger in the OME group (F(1.75) = 3.68 p = 0.05) and the Lower Anterior Facial height was smaller (F(1. 75) = 3.99 p = 0.05) in children with otitis media with effusion.Conclusions: There was no correlation between OME and facial pattern in children with ETA although a more horizontal facial growth direction, and a smaller lower anterior facial height was observed consistently among subjects in this group. This suggests that abnormal positioning of the eustachian tube influences the development of OME in children with ETA. 相似文献
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Milone G Leotta S Indelicato F Mercurio S Moschetti G Di Raimondo F Tornello A Consoli U Guido G Giustolisi R 《Bone marrow transplantation》2003,31(9):747-754
We performed a randomized study to compare 'G-CSF alone' (administered at dose of 10 mcg/kg/day) and 'cyclophosphamide plus G-CSF' (cyclophosphamide at dose of 4 g/m(2) and G-CSF at dose of 10 microg/kg/day), as PBPC mobilization schedules in 52 patients with NHL or HD. Randomization was stratified according to the amount of previous chemotherapy (< or =2 and >2 lines of previous chemotherapy). Mean CD34+ cell peak in P.B., mean 'Total CD34+ cells' harvested and percentage of patients successfully mobilized, in the group mobilized with 'G-CSF alone' vs the group mobilized with 'cyclophosphamide plus G-CSF', were: 35.3 x 10(6) vs 45.8 x 10(6)/l (P=0.3), 5.4 x 10(6) vs 6.8 x 10(6)/kg (P>0.9) and 50 vs 61% (P=0.4). No differences were observed in the stratum of less pretreated patients. However, in the stratum of patients who had previously received more than two lines of chemotherapy, CD34+cell peak (P=0.05) and percentage of successful mobilization (P=0.01) were higher when 'cyclophosphamide plus G-CSF' was used. Using logistic regression, both age and mobilization with 'G-CSF alone' were significantly associated with a low CD34+ cell peak in P.B. However, in the stratum of less pretreated patients, only age was significantly associated with this risk. 相似文献