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121.
Shaohong Peng Pei Guo Xiao Lin Ying An Kong Hung Sze Matthew Ho Yan Lau Zhefan Stephen Chen Qianwen Wang Wen Li Jacquelyne Ka-Li Sun Sum Yi Ma Ting-Fung Chan Kwok-Fai Lau Jacky Chi Ki Ngo Kin Ming Kwan Chun-Ho Wong Sik Lok Lam Steven C. Zimmerman Tiziano Tuccinardi Zhong Zuo Ho Yu Au-Yeung Hei-Man Chow Ho Yin Edwin Chan 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(19)
122.
Outcome after surgical resection of intraductal papillary and mucinous tumors of the pancreas 总被引:19,自引:0,他引:19
Cuillerier E Cellier C Palazzo L Devière J Wind P Rickaert F Cugnenc PH Cremer M Barbier JP 《The American journal of gastroenterology》2000,95(2):441-445
OBJECTIVE: Treatment of intraductal papillary and mucinous tumors of pancreas (IPMT) usually requires surgery. The objective of this study was to evaluate the risk of recurrence in patients after surgery according to the histological nature of the neoplasm and the type of surgery. METHODS: The outcome of 45 patients who underwent partial pancreatectomy (n = 35) or total pancreatectomy (n = 10) for IPMT was studied according to the nature of the neoplasm (invasive carcinoma or noninvasive neoplasm), type of surgery (partial or total pancreatectomy), and lymph nodes status. RESULTS: The overall 3-yr actuarial survival rate was 83%. Death occurred in seven of 20 (35%) patients with invasive carcinoma and in one of 26 (4%) patients with noninvasive tumors (p<0.05). There were two recurrences in the seven patients with noninvasive neoplasm who underwent partial pancreatectomy with involved resection margins, and none in the 13 patients with disease-free margins. In patients with invasive carcinoma, there was one recurrence after total pancreatectomy, six after partial pancreatectomy with disease-free margins and six after partial pancreatectomy with involved margins. In patients with invasive carcinoma, total pancreatectomy and the absence of lymph nodes involvement were independently associated with a low risk of recurrence. CONCLUSIONS: IPMT may be managed as follows: 1) in patients with noninvasive neoplasms, partial pancreatic resection should be guided by frozen section examination until disease-free margins are obtained; and 2) in patients with invasive carcinoma, total pancreatectomy seems most likely to cure the patient, but should be discussed according to the general status and the age. 相似文献
123.
Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae 总被引:6,自引:0,他引:6 下载免费PDF全文
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Prolactin (PRL) is a polypeptide hormone with a wide range of physiological functions, and is critical for female reproduction. PRL exerts its action by binding to membrane bound receptor isoforms broadly classified as the long form and the short form receptors. Both receptor isoforms are highly expressed in the ovary as well as in the uterus. Although signaling through the long form is believed to be more predominant, it remains unclear whether activation of this isoform alone is sufficient to support reproductive functions or whether both types of receptor are required. The generation of transgenic mice selectively expressing either the short or the long form of PRL receptor has provided insight into the differential signaling mechanisms and physiological functions of these receptors. This review describes the essential finding that both long and short receptor isoforms are crucial for ovarian functions and female fertility, and highlights novel mechanisms of action for these receptors. 相似文献
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Thierry Poynard Valentina Peta Olivier Deckmyn Mona Munteanu Joseph Moussalli Yen Ngo Marika Rudler Pascal Lebray Raluca Pais Luminita Bonyhay Frederic Charlotte Vincent Thibault Laetitia Fartoux Olivier Lucidarme Daniel Eyraud Olivier Scatton Eric Savier Marc Antoine Valantin An Ngo Fabienne Drane Olivier Rosmorduc Franoise Imbert‐Bismut Chantal Housset Dominique Thabut Vlad Ratziu 《Alimentary pharmacology & therapeutics》2019,49(3):308-320
130.
Malvastrum coromandelianum L. (Garcke) is extensively used in traditional medicinal systems to treat various ailments. In the present study, an alkali-soluble polysaccharide (MAP) was isolated from the leaves of M. coromandelianum in 1.15% (w/w) yield. MAP was composed of l-rhamnose, l-arabinose, d-xylose, d-glucose and d-galactose in a 1.00 : 6.04 : 19.88 : 1.07 : 3.03 molar ratio along with d-glucuronic acid (1.95). Methylation/linkage analysis revealed a backbone of →4)-β-d-Xylp(1→ (30.09 mol%) with a side chain of →3)-α-l-Araf(1→ (15.21 mol%) residues. The structure of MAP was elucidated by a combination of degradative and derivatization techniques, including hydrolysis, alditol acetate derivatization, methylation, GC-MS, partial hydrolysis, ESI-MS and NMR (1D, 2D) spectral analysis. Based on correlation analysis, MAP was found to be an arabinoxylan comprising a backbone of →4)-β-d-linked Xylp(1→ with branching at O-2 by a →3)-α-l-Araf(1→ and →3)-β-d-Xylp(1→ chain. MAP also exhibited ferric ion reducing activity, with a reducing power of 0.914 ± 0.01 (R2 = 0.972) at 1 mg mL−1 concentration, which showed dose-dependent behavior. MAP can be utilized as a potential antioxidant.The structure of MAP was studied by degradative, derivatization and spectroscopic methods, and it was found to be an arabinoxylan comprising a backbone of →4)-β-d-linked Xylp(1→ with branching at O-2 by →3)-α-l-Araf(1→ and →3)-β-d-Xylp(1→ chains. 相似文献