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71.
Oikonomou D Hassan K Kaifi JT Fiegel HC Schurr PG Reichelt U Aridome K Yekebas EF Mann O Kluth D Strate T Izbicki JR 《Journal of cancer research and clinical oncology》2007,133(12):951-955
Purpose Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem
cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs.
Materials and methods Fifty-seven surgically resected and paraffin-embedded GIST samples were analyzed by immunohistochemistry with peroxidase method
for Thy-1 molecule.
Results Thy-1 was detected in the majority of 57 GIST samples (54 out of 57 patients, 95%). All samples were c-kit positive and 90% were CD34 positive. All three Thy-1 negative samples were CD34 positive, had a low proliferative index (Ki-67 ≤ 10%) and were located in the upper gastrointestinal tract (one in esophagus and two in the stomach). As a tendency, Thy-1
negative patients had a better prognosis, although not reaching level of significance due to low numbers.
Conclusions Thy-1 is expressed in the majority of GISTs, suggesting a novel, additional standard marker for identifying GIST. Future studies
should focus on the role of Thy-1 in the pathogenesis of GIST and subsequently on its potential to act as a molecular target
for adjuvant therapy with new molecular antitumor agents.
Financial support for this study was provided by research grants from the Hamburger Krebsgesellschaft e. V. (J.T.K., E.F.Y., J.R.I.). 相似文献
72.
Eftychia Ferentinou ;Ioannis Koutelekos ;Evangelos Dousis ;Eleni Evangelou ;Despoina Pappa ;Maria Theodoratou ;Chrysoula Dafogianni 《AIMS Public Health》2025,12(1):77-90
Sleep duration and quality have been increasingly recognized as critical determinants of childhood obesity risk, with insufficient sleep linked to disruptions in appetite-regulating hormones and unhealthy weight gain trajectories. Emotional intelligence, which involves recognizing, understanding, and managing one's own emotions as well as those of others, has garnered attention for its potential impact on VARIOUS aspects of health and well-being, including weight management. Moreover, childhood obesity remains a significant public health concern worldwide, with multifaceted factors contributing to its prevalence and persistence. Research is starting to reveal how sleep patterns and emotional intelligence (ΕΙ) influence children's weight status. This study aims to investigate the relationship between childhood sleep patterns, EI, and body mass index (BMI) in school-aged children. Utilizing a sample of 614 children, aged 8–12 years (mean age 10.0 y), data on emotional intelligence scores, sleep duration and quality, and BMI measurements were collected and analyzed. The results reveal significant correlations among these variables, indicating that emotional intelligence may play a crucial role in both sleep patterns and BMI outcomes in children (Mean = 3.53, SD = 0.51 in total sample; Mean = 3.53, SD = 0.51 in overweight/obese). Specifically, higher emotional intelligence scores are associated with better sleep quality and duration, as well as healthier BMI levels (p ≤ 0.001). These findings underscore the importance of considering emotional well-being and sleep hygiene in the context of childhood obesity prevention and intervention efforts. Further research is needed to elucidate the underlying mechanisms driving these relationships and to develop targeted strategies for promoting emotional intelligence and healthy sleep habits in school-aged children. 相似文献
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Nikos Papakonstantinou Stavroula Ntoufa Maria Tsagiopoulou Theodoros Moysiadis Sujata Bhoi Andigoni Malousi Fotis Psomopoulos Larry Mansouri Stamatia Laidou Despoina Papazoglou Maria Gounari Konstantinos Pasentsis Karla Plevova Venera Kuci-Emruli Marti Duran-Ferrer Zadie Davis Sara Ek Davide Rossi Gianluca Gaidano Matthias Ritgen David Oscier Niki Stavroyianni Sarka Pospisilova Frederic Davi Paolo Ghia Anastasia Hadzidimitriou Chrysoula Belessi Jose I Martin-Subero Christiane Pott Richard Rosenquist Kostas Stamatopoulos 《International journal of cancer. Journal international du cancer》2019,144(11):2695-2706
Chronic lymphocytic leukemia (CLL) stereotyped subsets #6 and #8 include cases expressing unmutated B cell receptor immunoglobulin (BcR IG) (U-CLL). Subset #6 (IGHV1-69/IGKV3-20) is less aggressive compared to subset #8 (IGHV4-39/IGKV1(D)-39) which has the highest risk for Richter's transformation among all CLL. The underlying reasons for this divergent clinical behavior are not fully elucidated. To gain insight into this issue, here we focused on epigenomic signatures and their links with gene expression, particularly investigating genome-wide DNA methylation profiles in subsets #6 and #8 as well as other U-CLL cases not expressing stereotyped BcR IG. We found that subset #8 showed a distinctive DNA methylation profile compared to all other U-CLL cases, including subset #6. Integrated analysis of DNA methylation and gene expression revealed significant correlation for several genes, particularly highlighting a relevant role for the TP63 gene which was hypomethylated and overexpressed in subset #8. This observation was validated by quantitative PCR, which also revealed TP63 mRNA overexpression in additional nonsubset U-CLL cases. BcR stimulation had distinct effects on p63 protein expression, particularly leading to induction in subset #8, accompanied by increased CLL cell survival. This pro-survival effect was also supported by siRNA-mediated downregulation of p63 expression resulting in increased apoptosis. In conclusion, we report that DNA methylation profiles may vary even among CLL patients with similar somatic hypermutation status, supporting a compartmentalized approach to dissecting CLL biology. Furthermore, we highlight p63 as a novel prosurvival factor in CLL, thus identifying another piece of the complex puzzle of clinical aggressiveness. 相似文献
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Georgios Spyropoulos Kalliopi Domvri Katerina Manika Evangelia Fouka Theodoros Kontakiotis Despoina Papakosta 《Journal of thoracic disease》2022,14(6):1941
BackgroundThe aim of the present study was the application of the latest phenotype recommendations in Greek patients, in order to identify specific clinical, imaging and spirometric characteristics, at initial diagnosis of sarcoidosis, related to disease phenotypes.MethodsOur cohort included 147 patients coming from Northern Greece, recruited from the Outpatient Sarcoidosis Clinic, of Aristotle University of Thessaloniki. The observation period was 5 years. The Scadding staging system and the World Association of Sarcoidosis and other Granulomatous Disorders (WASOG) Clinical Outcome Status instrument were used. Phenotypes were defined by the latest DELPHI consensus recommendations.ResultsThe following clinical phenotypes were identified: asymptomatic 59%, acute 14.3%, chronic 12.9% and advanced 33.3%. The observed phenotypes were not related to Scadding stages. Lung function decline was in line with phenotype severity. The presence of fibrosis to any extent upon diagnosis differed among phenotypes (asymptomatic 13.8%, acute 38.1%, chronic 57.9%, advanced 61.2%, P<0.001) and was common for relapsing patients (P<0.001). In spontaneously remitting patients, fibrosis upon diagnosis was found less often than in non-remitting patients (P<0.001). Renal involvement was more frequently found in the advanced phenotype (P=0.032). Skin involvement was more common for patients with acute onset (P<0.001) and spontaneous remission (P=0.012). Ocular involvement was mainly found in relapsing patients (P<0.001).ConclusionsIn our cohort, sarcoidosis clinical phenotypes have certain clinical, imaging and functional characteristics, at initial diagnosis of the disease, which could be assessed in everyday practice. 相似文献
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