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排序方式: 共有344条查询结果,搜索用时 15 毫秒
11.
M. Rizzetto K. Grotzinger D. Theodore D. Demuth W. L. Irving M. Manns A. Roughley U. M. Forssen 《Journal of viral hepatitis》2014,21(10):e129-e134
Antiviral therapy has been shown to reduce the risk of disease progression, liver damage and death in patients with chronic hepatitis C virus (HCV) infection. While interferon labels recommend that patients with platelet counts below 50 × 103/μL not receive interferon‐based therapy, it is unknown to what extent thrombocytopaenia influences treatment decisions in practice. This study profiles the reasons for withholding antiviral treatment in HCV patients with thrombocytopaenia in five European countries. Medical records of 466 patients who had HCV infection and thrombocytopaenia (platelet count <100 × 103/μL) in 2006 were retrospectively reviewed for clinical characteristics. Collected data included use of antiviral therapy and reasons for withholding therapy. In total 184 of 466 patients (39.5%) did not receive interferon‐based therapy during the study period, with treatment withheld most frequently due to multiple clinical characteristics including hepatic cirrhosis (16.3%), thrombocytopaenia (16.3%) and age >60 years (10.9%). The reasons for lack of treatment varied among countries, with thrombocytopaenia as a reason being more common in Italy (10.9%) and Spain (20.0%), and less common in France, Germany and the UK (3.2–7.1%). Overall, thrombocytopaenia was reported as the only reason for withholding treatment in 4.9% of untreated patients. This study demonstrates that thrombocytopaenia is one of many factors, indicative of the poor clinical state of the patient, that contributes to withholding antiviral treatment. In 4.9% of untreated patients, thrombocytopaenia can be considered as a modifiable factor to enable more HCV patients to receive guideline‐recommended therapy and thus improved clinical outcomes. 相似文献
12.
Wiener Medizinische Wochenschrift - Im vorliegenden Fallbericht wird die Situation einer 67-jährigen chronischen Schmerzpatientin geschildert, die aufgrund eines Zufallsbefundes mit der... 相似文献
13.
Demuth K Drunat S Girerd X Moatti N Paul JL Safar M Boutouyrie P 《Atherosclerosis》2002,165(1):167-174
Several authors have reported that moderate hyperhomocysteinemia is related to asymptomatic carotid arterial wall remodeling, but few data are available on other thiol compounds with potential vascular toxicity. We, therefore, investigated the relationships between major plasma thiol compounds (homocysteine, cysteine and glutathione) and the structural phenotype of the common carotid artery in a cohort of 123 subjects with no evidence of cardiovascular disease. Fasting levels of thiol compounds were measured by high-performance liquid chromatography, and arterial geometry was evaluated using high-resolution echotracking devices. In univariate regression analysis, plasma homocysteine and plasma cysteine concentrations were positively associated with carotid artery internal diameter (P=0.0001 and 0.002, respectively) and intima media thickness (P=0.003 and 0.004), but the plasma glutathione concentration was not. In multivariate analysis, plasma homocysteine was independently and positively associated with carotid artery internal diameter (P<0.005) and intima media thickness (P<0.05), but plasma cysteine was not. These data suggest that homocysteine is the only plasma thiol compound that may be considered as a risk factor for preclinical cardiovascular disease. 相似文献
14.
Lorenz Rieck Frieda Bardey Thomas Grenkowitz Lars Bertram Johannes Helmuth Claudia Mischung Joachim Spranger Elisabeth Steinhagen-Thiessen Thomas Bobbert Ursula Kassner Ilja Demuth 《Clinical genetics》2020,98(5):457-467
Autosomal-dominant familial hypercholesterolemia (FH) is characterized by increased plasma concentrations of low-density lipoprotein cholesterol (LDL-C) and a substantial risk to develop cardiovascular disease. Causative mutations in three major genes are known: the LDL receptor gene (LDLR), the apolipoprotein B gene (APOB) and the proprotein convertase subtilisin/kexin 9 gene (PCSK9). We clinically characterized 336 patients suspected to have FH and screened them for disease causing mutations in LDLR, APOB, and PCSK9. We genotyped six single nucleotide polymorphisms (SNPs) to calculate a polygenic risk score for the patients and 1985 controls. The 117 patients had a causative variant in one of the analyzed genes. Most variants were found in the LDLR gene (84.9%) with 11 novel mutations. The mean polygenic risk score was significantly higher in FH mutation negative subjects than in FH mutation positive patients (P < .05) and healthy controls (P < .001), whereas the score of the two latter groups did not differ significantly. However, the score explained only about 3% of the baseline LDL-C variance. We verified the previously described clinical and genetic variability of FH for German hypercholesterolemic patients. Evaluation of a six-SNP polygenic score recently proposed for clinical use suggests that it is not a reliable tool to classify hypercholesterolemic patients. 相似文献
15.
16.
V. E. Mertens Pickhan F. Klopstock Collier Krah Hartmann Sponholz V. E. Mertens Demuth Cokkalis Carl Feldmann und Gerlach 《Journal of cancer research and clinical oncology》1931,33(1):32-37
Ohne Zusammenfassung 相似文献
17.
Werner Faust Konrad Lang Lehnartz Druckrey A. Fröhlich Langendorff Demuth Hartmann Hinsberg Orzechowski Mühlbock A. Juhász-Schäffer Reiss 《Journal of cancer research and clinical oncology》1936,43(2-3):74-80
Ohne Zusammenfassung 相似文献
18.
19.
Markus Morawski Maike Hartlage-Rübsamen Carsten Jäger Alexander Waniek Stephan Schilling Claudia Schwab Patrick L. McGeer Thomas Arendt Hans-Ulrich Demuth Steffen Roßner 《Acta neuropathologica》2010,120(2):195-207
Glutaminyl cyclase (QC) was discovered recently as the enzyme catalyzing the pyroglutamate (pGlu or pE) modification of N-terminally
truncated Alzheimer’s disease (AD) Aβ peptides in vivo. This modification confers resistance to proteolysis, rapid aggregation
and neurotoxicity and can be prevented by QC inhibitors in vitro and in vivo, as shown in transgenic animal models. However,
in mouse brain QC is only expressed by a relatively low proportion of neurons in most neocortical and hippocampal subregions.
Here, we demonstrate that QC is highly abundant in subcortical brain nuclei severely affected in AD. In particular, QC is
expressed by virtually all urocortin-1-positive, but not by cholinergic neurons of the Edinger–Westphal nucleus, by noradrenergic
locus coeruleus and by cholinergic nucleus basalis magnocellularis neurons in mouse brain. In human brain, QC is expressed
by both, urocortin-1 and cholinergic Edinger–Westphal neurons and by locus coeruleus and nucleus basalis Meynert neurons.
In brains from AD patients, these neuronal populations displayed intraneuronal pE-Aβ immunoreactivity and morphological signs
of degeneration as well as extracellular pE-Aβ deposits. Adjacent AD brain structures lacking QC expression and brains from
control subjects were devoid of such aggregates. This is the first demonstration of QC expression and pE-Aβ formation in subcortical
brain regions affected in AD. Our results may explain the high vulnerability of defined subcortical neuronal populations and
their central target areas in AD as a consequence of QC expression and pE-Aβ formation. 相似文献
20.
The longitudinal course of two sisters with multiple pterygium syndrome is reported. The findings in these siblings are compared with those of 27 children described in the medical literature. The longitudinal course of short stature, scoliosis, talipes equinovarus, pterygia, hearing loss, and pubertal and intellectual development in this syndrome is described. Recommendations are made for a multidisciplinary approach to individuals with multiple pterygium syndrome, which includes the services of a primary care physician, orthopedist, physical therapist, and plastic surgeon. 相似文献