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81.
82.
Pentoxifylline, a xanthine analogue was evaluated for efficacy, safety and tolerance in the treatment of intermittent claudication in a pilot study. Evaluation was performed in 35 cases. 20 patients were given Pentoxifylline in doses of 1200 mg daily, and 15 patients were given placebo for a period of 8 weeks respectively. Pentoxifylline given in doses of 1200 mg was significantly more effective than the placebo in increasing both the initial and absolute claudication distance (ICD & ACD) in patients with chronic occlusive arterial disease. The subjective parameters, such as paraesthesias, muscular cramps and sensation of heaviness in the legs paralleled the course of walking parameters. These results support the hypothesis that Pentoxifylline in doses of 400 mg TDS reduces blood viscosity by improving red cell flexibility, and thereby enhances blood flow in patients with COAD (Fontaine Stage II or Stage III). Pentoxifylline is thus regarded as a promising drug for circulatory ischaemic disorders, especially in intermittent claudication. It was well tolerated with minimal untoward effects. 相似文献
83.
Sharma Vishal Singh Anoop Gaur Mohita Rawat Deepti Yadav Anjali Rajan Kumar Chanchal Varma-Basil Mandira Lohiya Sheelu Khanna Vishal Khanna Ashwani Chaudhry Anil Singh Yogendra Misra Richa 《European journal of clinical microbiology & infectious diseases》2022,41(6):893-906
European Journal of Clinical Microbiology & Infectious Diseases - Precise and timely detection of tuberculosis (TB) is crucial to reduce transmission. This study aims to assess the accuracy of... 相似文献
84.
Matthew L. Goldman Brigitta Spaeth-Rublee Abraham D. Nowels Parashar Pravin Ramanuj Harold Alan Pincus 《Current psychiatry reports》2016,18(4):39
The development of quality measures has gained increasing attention as health care reimbursements transition from fee-for-service to value-based payment models. As behavioral health care moves towards integration of services with primary care, specific measures and payment incentives will be needed to successfully expand access. This study uses a keyword search to identify 730 quality indicators that are relevant to behavioral health and general medical health. Measures identified have been coded and grouped into domains based on a taxonomy developed by the authors. The analysis reveals that quality measures focusing on general medical conditions exceed those focused on behavioral health diagnoses for evidence-based treatments, patient safety, and outcomes. Furthermore, measures predominantly concentrate on care during or following hospitalizations, which represents a minority of behavioral health care and does not characterize the outpatient settings that are the focus of many models of integrated care. The authors offer recommendations for future steps to identify the quality measures that can best evaluate the evolving behavioral health care system. 相似文献
85.
86.
Deepali Gupta Surjit Singh Deepti Suri Jasmina Ahluwalia Reena Das Neelam Varma 《Rheumatology international》2010,30(6):767-770
The objectives of this study are to highlight the arthritic presentation of acute lymphoblastic leukemia (ALL) in children
and to delineate features that could help differentiate it from juvenile idiopathic arthritis (JIA). We present a retrospective
case control study based on records of the Pediatric Rheumatology Clinic, Advanced Pediatric Centre, Post Graduate Institute
of Medical Education and Research, Chandigarh, India for the period January 2005–October 2008. We compared the clinical profile
of 11 children referred to us with musculoskeletal complaints who were ultimately diagnosed to have ALL, with the clinical
profile of an equal number of age and sex matched children with JIA. Important features that predicted a diagnosis of ALL
and differentiated it from JIA were history of night pain (P = 0.001), non-articular bony pain (P = 0.001), presence of joint pain out of proportion to physical findings (P = 0.0001), anemia (P = 0.004), leucopenia (P = 0.045), lymphocytic predominance (P = 0.002) and thrombocytopenia (P = 0.012). In conclusion, children with musculoskeletal complaints are often referred to the rheumatologist for evaluation.
The treating physician should always exclude the possibility of an underlying ALL especially if there are atypical clinical
features or subtle hematological abnormalities. 相似文献
87.
88.
Deepti Suri Neeraj Gupta Chandrashekara Morigeri Akshay Saxena Rohit Manoj 《Pediatric nephrology (Berlin, Germany)》2009,24(6):1243-1245
We report on a 4-year-old girl with steroid-resistant nephrotic syndrome who presented with life-threatening chylopericardial
tamponade with chylothorax secondary to superior vena cava thrombosis. This is the first case report of this complication
in a child. We outline the treatment, which included emergency pericardiocentesis and thoracostomy, parentral anticoagulation
and dietary modifications. This therapeutic regimen resulted in a good outcome.
All authors contributed equally to this work. 相似文献
89.
Treatment of syndactyly necessitates creation of neo-web space and separation of fingers. Traditionally, this has been done
by use of flaps taken from the dorsum; the resultant raw areas thus created have been managed by use of skin grafts. The classical
teaching has been that the separated fingers will need skin graft as primary closure is not possible. The skin grafts have
a tendency to contract and lead to finger flexion contractures and “creep” of the web space. We describe a flap based upon
subcutaneous tissue in the web that is moved in a V–Y fashion to resurface the neo-web. The flap donor site can easily be
closed primarily. The fingers are then separated; the subcutaneous fat is carefully removed from the finger flaps under magnification
to allow primary closure of the finger defects. It has been possible to primarily close the donor site and fingers in all
the patients. The procedure has been used in seven patients with 14 web releases. The age varied between 10 months to 3 years.
The V–Y advancement flap based upon the subcutaneous pedicle in the region of the web allows adequate creation of a new web
space. The careful de-fattening of skin flaps allows the separated fingers to be closed primarily. 相似文献
90.
Opinion statement Depression is common in the community and is a risk factor for the development of coronary heart disease (CHD). In patients
with CHD, the prevalence of major depression is nearly 20% and the prevalence of minor depressive disorder is approximately
27%. When present in patients with existing CHD, depression is independently associated with worse outcome, including higher
morbidity and mortality, and worse health status. Observational studies suggest that use of antidepressant medications in
patients with CHD is associated with decreased risk of cardiovascular events. However, only one randomized controlled trial,
the ENRICHD (Enhancing Recovery in Coronary Heart Disease) study, was designed to evaluate whether treatment of depression
in patients with CHD can improve cardiac prognosis. Although the study showed that cognitive behavior therapy was better than
usual care in improving depression, there was no improvement in all-cause mortality or recurrent cardiac events. There have
been no clinical trials specifically designed to evaluate whether pharmacologic treatment of depression improves cardiovascular
outcomes in patients with CHD. Thus, there is a clear need for additional trials testing interventions to improve cardiac
prognosis based on treatment of depression. In the meantime, depression remains an important illness in its own right and
deserves treatment. Safe and effective treatments of depression in patients with CHD include cognitive behavior therapy and
selective serotonin reuptake inhibitors. 相似文献