全文获取类型
收费全文 | 466115篇 |
免费 | 40318篇 |
国内免费 | 26676篇 |
专业分类
耳鼻咽喉 | 3911篇 |
儿科学 | 7694篇 |
妇产科学 | 6465篇 |
基础医学 | 53410篇 |
口腔科学 | 8229篇 |
临床医学 | 60257篇 |
内科学 | 70682篇 |
皮肤病学 | 6076篇 |
神经病学 | 26675篇 |
特种医学 | 17375篇 |
外国民族医学 | 247篇 |
外科学 | 46012篇 |
综合类 | 71472篇 |
现状与发展 | 86篇 |
一般理论 | 78篇 |
预防医学 | 32839篇 |
眼科学 | 12125篇 |
药学 | 48134篇 |
437篇 | |
中国医学 | 24839篇 |
肿瘤学 | 36066篇 |
出版年
2024年 | 1317篇 |
2023年 | 5826篇 |
2022年 | 15318篇 |
2021年 | 19971篇 |
2020年 | 15470篇 |
2019年 | 13208篇 |
2018年 | 14056篇 |
2017年 | 13110篇 |
2016年 | 12281篇 |
2015年 | 18574篇 |
2014年 | 23264篇 |
2013年 | 22504篇 |
2012年 | 32948篇 |
2011年 | 36639篇 |
2010年 | 24629篇 |
2009年 | 20228篇 |
2008年 | 25622篇 |
2007年 | 25544篇 |
2006年 | 24360篇 |
2005年 | 23272篇 |
2004年 | 17065篇 |
2003年 | 16453篇 |
2002年 | 14284篇 |
2001年 | 12167篇 |
2000年 | 11926篇 |
1999年 | 11312篇 |
1998年 | 6399篇 |
1997年 | 5947篇 |
1996年 | 4749篇 |
1995年 | 4483篇 |
1994年 | 3807篇 |
1993年 | 2679篇 |
1992年 | 4185篇 |
1991年 | 3866篇 |
1990年 | 3268篇 |
1989年 | 2987篇 |
1988年 | 2594篇 |
1987年 | 2356篇 |
1986年 | 2115篇 |
1985年 | 1703篇 |
1984年 | 1127篇 |
1983年 | 960篇 |
1982年 | 585篇 |
1981年 | 549篇 |
1980年 | 463篇 |
1979年 | 718篇 |
1978年 | 487篇 |
1974年 | 521篇 |
1973年 | 498篇 |
1972年 | 458篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Fady K. Baddoura Isam W. Nasr Barbara Wrobel Qi Li Nancy H. Ruddle Fadi G. Lakkis 《American journal of transplantation》2005,5(3):510-516
Lymphoid neogenesis is the process by which ectopic lymphoid accumulations that resemble lymph nodes arise in nonlymphoid tissues. Such lymphoid accumulations, known as tertiary lymphoid organs (TLO), are observed in chronic autoimmunity and they propagate immune pathology by setting up local antigen presenting sites. Whether lymphoid neogenesis occurs in transplanted organs and contributes to rejection is not well understood. To begin to address this question, we retrospectively analyzed 319 murine cardiac allografts for microscopic evidence of lymph-node-like structures. We found 78 allografts that had either classical TLO, characterized by discrete T- and B-cell zones and high endothelial venules (HEV) expressing peripheral node addressin (PNAd) (n = 34), or PNAd(+) HEV without organized lymphoid accumulations (n = 44). These changes were present in both short- and long-lived allografts and were invariably associated with rejection. Importantly, they occurred in 78% of allografts undergoing chronic rejection (n = 85) but in only 7% of allografts undergoing primarily acute rejection (n = 184). These findings indicate that, like autoimmunity, alloimmunity is associated with lymphoid neogenesis in the target organ and suggest a role for local T-cell activation in chronic allograft rejection. 相似文献
82.
面神经评分标准 总被引:11,自引:0,他引:11
李健东 《国外医学:耳鼻咽喉科学分册》2005,29(6):391-391
Sunnybrook(多伦多)面神经评定系统是近年来发展起来的一种新的面神经功能主观评定系统[1,2],得到了很多学的认可,在2005年9月在荷兰召开的国际面神经大会上,有近1/4的论用到了这一评分标准;而国内学们很少使用此标准,所以有必要向国内的同道作一介绍. 相似文献
83.
84.
笔者毕业后十余年中,临床上遇到心脑血管病人大部分正在应用西药治疗,中医讲究辨证论治,西药是否影响中医的辨证,临床上脉象是否随着西药运用而改变呢?中医脉象学是中医诊病、治病重要手段,望闻问切中“切诊”是主要组成部分。脉象变化是辨证论治重要依据,求证离不开脉象,组成脉象的主要因素及原因有:①脉位:脉动显现部位的浅深,脉位表浅为浮脉,深沉为沉弦;②至数:脉搏的频率,以一个呼吸周期为单位,一息脉来四~五至为平脉,一息六至为数脉,一息三至为迟脉;③脉长:脉动应指的轴向范围长短,越超三部脉象称为长脉,应指不及三部,但见关部或寸部者… 相似文献
85.
Marcel J. Kooy Wouter S. Dessing Esther F. Kroodsma Steven R. J. G. Smits Esther H. Fietje Martine Kruijtbosch Peter A. G. M. De Smet 《Pharmacy World & Science》2007,29(2):81-89
OBJECTIVE: According to a report published by the federation of Dutch patients' associations, patients would like to see a pharmacist, who acts more as a personal adviser. This raised the question, how often Dutch community pharmacists have personal consultations with their patients in daily practice, on which factors this depends, and what kind of topics are discussed during these meetings. SETTING: Community pharmacies in the Netherlands. METHOD: A questionnaire was distributed among 800 randomly selected pharmacies. Questions were restricted to consultations characterized by one-to-one contact, drug therapy related content, and adequate privacy. These consultations were labelled as pharmaceutical consultations in private to distinguish them from other contacts between pharmacists and patients. MAIN OUTCOME MEASURE: Number, content, and character of consultations. RESULTS: 198 (24.8%) community pharmacies responded. The pharmacists provide an average of roughly 1.2 consultations in private per working day. The vast majority of respondents provided face-to-face and telephone consultations (94.4 and 91.9%, respectively), only a minority gave consultations by e-mail (30.8%). These consultations primarily dealt with topics related to medication safety. The mean overall time spent was 290 min per month. A relatively high frequency of personal consultations was significantly associated with the absolute number of full-time equivalent pharmacists in the pharmacy. CONCLUSION: The frequency of pharmaceutical consultations in private is low, but may be improved by reorganisation of the pharmacist's activities. The possibility of personal consultations by e-mail is not yet well-developed. Further research is needed to assess the patient's view of pharmaceutical consultations in private. 相似文献
86.
87.
对中等医药学校实习科的管理工作进行新的尝试,并提出新的管理措施,旨在通过完善的实习管理,开展各项实习工作,帮助学生巩固和掌握本专业课程应具备的基本知识和技能。 相似文献
88.
腰椎节段形态对峡部、小关节应力及小关节接触力影响的有限元分析 总被引:1,自引:0,他引:1
目的:探讨腰椎形态结构变化对峡部裂性滑脱及小关节退变的作用和意义。方法:采用改良的“非种子区域分割方法”及非平行“最佳切割平面”等一系列新型计算机辅助设计(CAD)方法精确建立包括椎间盘高度、腰椎小关节角、椎间盘前凸角改变的L4~L5活动节段有限元模型;在2700N轴向压缩载荷条件下,分别对各有限元模型的峡部、小关节应力、小关节接触力以及椎间盘负载进行测试。结果:压缩载荷下,腰椎活动节段峡部、小关节等效应力及小关节接触力随椎间盘高度的减小而减小,随小关节角的增大而增加,随椎间盘前凸角的增加而减小。结论:椎间盘高度、腰椎小关节角、椎间盘前凸角等形态结构变化对腰椎节段有限元模型的峡部、小关节应力及小关节接触力有明显的影响。提示腰椎峡部应力性骨折及小关节退变的发生与椎间盘高度、腰椎小关节角、椎间盘前凸角等解剖形态因素有关。 相似文献
89.
Lin Bo Wang Jian Guo Shen Li Feng Dong Chao Yang Xu Wen Jun Chen Shu Duo Xie Xiang Yang Song Ning Dai Xiao Ming Yuan 《Journal of gastrointestinal surgery》2008,12(8):1359-1363
We previously reported that lymphatic mapping using isosulfan blue can be used to identify sentinel nodes (SNs). This study
was undertaken to evaluate the feasibility of using the SN technique in treating early gastric cancer and to explore its usefulness
for minimal invasive surgery. Twenty-three patients with early gastric cancer who underwent SN biopsy were retrospectively
evaluated. Based on SN evaluation, individualized surgery was performed in five patients with T1N0M0 gastric cancer. When
pathological examination of frozen sections revealed metastasis in SNs, we performed a standard D2 gastrectomy. Laparoscopic
local resection was applied when the SN biopsy was negative. Our results showed that the success rate with SN biopsy in early
gastric cancer was 100%, as were the accuracy, sensitivity, and specificity. All five patients with early gastric cancer had
SNs negative for metastases both by frozen section and by postoperative pathology. Thus, all these patients underwent laparoscopic
local resection without extended lymphadenectomy. We conclude that SN biopsy is a useful tool to individualize the operative
procedure, and laparoscopic local resection can be safely performed using SN guidance in selected patients with early gastric
cancer. 相似文献
90.
Roberto H. Caraballo Laura Gañez Cecilia De los Santos Alberto Espeche Ricardo Cersósimo Natalio Fejerman 《Seizure》2009,18(10):686-689
PurposeTo analyze the electroclinical features, aetiology and outcome in patients with normal neurological examination and psychomotor development who presented seizures during a mild gastroenteritis (MG).Patients and methodsEvaluation of the clinical charts of 22 patients who were assessed in the Neurology Department, Hospital Nacional de Pediatría Prof. Dr. JP Garrahan between 1999 and 2007.ResultsTwelve patients were boys and 10 were girls, the age of onset ranged from 5 to 26 months, and the median age was 10 months. Rotavirus antigen test in stool was positive in 9 of 18 studied patients. The seizures were brief, focal with secondary generalization in 15 patients (68.5%), apparently generalized in 5 (22.5%) and focal in two (9%). Seven of the patients (35%) had more than one seizure in 24 h. The interictal EEG was normal in all patients. Neuroradiological studies were performed in 19 patients with a normal result. No patient was put on long-term treatment with antiepileptic drugs. Four patients had subsequent mild gastroenteritis and two of them presented convulsions during the disease. After between 12 and 67 months of follow-up, all patients had normal psychomotor development and neurological examination.ConclusionsIn this study we confirmed the association of benign infantile seizures (BIS) and MG with or without rotavirus. The identification of this entity allows avoiding unnecessary complementary studies and treatment with antiepileptic drugs. 相似文献