Wissenstranslation am Beispiel Bewegungsförderung von älteren Menschen: Wie gelangen wissenschaftliche Erkenntnisse in die kommunale Praxis?

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Wissenschaftliche Ergebnisse können eine Wissensquelle für kommunale Akteurinnen und Akteure der...     

Aufbau von Interventionsdatenbanken für mehr Evidenzbasierung in Prävention und Gesundheitsförderung – methodische Überlegungen

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Kommunale AkteurInnen erfahren bei der Entwicklung und Auswahl von Maßnahmen der Prävention und...     

FAM19A4基因启动子甲基化检测在宫颈癌及其癌前病变筛查的研究

宫颈癌是最常见的妇科恶性肿瘤之一。目前人乳头瘤病毒(HPV)检测及细胞学检查是宫颈癌及其癌前病变(CCPL)的主要筛查手段。由于上述传统筛查方法,仍然存在对CCPL漏诊的风险,因此寻找有效识别CCPL的特异性分子标志物,具有重要临床意义。对具有序列相似性家族19成员A4(FAM19A4)基因启动子甲基化定量检测,可有效检出CCPL组织,较传统筛查方法有较高特异度,有望成为CCPL筛查的特异性分子标志物。笔者拟就FAM19A4基因启动子甲基化定量检测,在CCPL筛查中应用的最新研究现状进行阐述,旨在为进一步推进CCPL筛查方法的开发,提供思路。     

桡骨远端瘤段切除带血管蒂的腓骨移植重建桡腕关节

目的：探讨桡骨远端骨肿瘤切除术,吻合血管的带腓骨头腓骨近端移植修复桡骨远段缺损和重建桡腕关节的疗效。方法：17例桡骨远端骨肿瘤患者行桡骨远端切除,应用吻合血管的带腓骨近段移植修复骨缺损并重建模腕关节。移植体行简单内固定＋外固定;术后定期复查X线片,Dopplar血管超声,及腕关节功能评定。结果：随访3个月－2年,全部病例均于手术3个月后达一期骨愈合;其中1例因钢板螺丝钉动再次行内固定而愈合。评定重建腕关节功能,优12例,良3例,差2例。病灶无复发。结论：桡骨远端骨肿瘤切除后行吻合血管的带腓骨头腓骨近端移植修复骨缺损并重建腕关节。手术切除彻底,复发率低,重建后的腕关节功能良好。     

1H-NMR and NOE studies of 2-cephems and 3-cephems

The¹H-NMR signals of 2-cephems and 3-cephems have been assigned and the Nuclear Overhauser Effect (NOE) study of these compounds was undertaken.     

Cystoid macular edema in anterior chamber lens implantation following posterior capsule rupture

By comparing the incidence of cystoid macular edema (CME) in three groups of patients having different surgical procedures, we attempted to assess the role of vitreous loss as a risk factor for CME development. In the first group (n = 470), the surgical procedure was extracapsular cataract extraction followed by implantation of posterior chamber lens (EC-CE + PC-IOL). The second group (n = 42) had extracapsular cataract extraction which was complicated by posterior capsule rupture, and therefore anterior vitrectomy followed by implantation of anterior chamber lens had to be performed (ECCE + anterior vitrectomy + AC-IOL). In the third group (n = 22) the surgery was intracapsular cataract extraction followed by anterior chamber lens implantation (ICCE + AC-IOL). The third group was included in this follow up study to assess the role of AC-IOL as a possible causative factor for development of CME in uncomplicated cases of ICCE and AC-IOL. The difference of incidences of CME in the second and third group would therefore depend mostly on the vitreous loss. The incidence of CME diagnosed by fluorescein angiography in the first, second and third group was 1.5% (7/470), 35.7% (15/42) and 9.0% (2/22), respectively. All patients who developed CME were treated with combination of corticosteroid-antibiotic drops, dexamethasone retrobulbarly (40 mg/day) and peroral indomethacine (25 mg/day/6 weeks). This therapeutic regime resulted in only moderate improvement of visual acuity.Abbreviations AC-IOL anterior chamber intraocular lens - CME cystoid macular edema - ECCE extracapsular cataract extraction - ICCE intracapsular cataract extraction - IOL intraocular lens - PC-IOL posterior chamber intraocular lens     

老年人非酒精性脂肪性肝病与血脂血糖水平及体重指数的关系

目的探讨老年人非酒精性脂肪性肝病(NAFLD)与血脂血糖水平、体重指数等指标的关系。方法298例老年人按非酒精性脂肪性肝病诊断标准分为脂肪肝组(114例)和非脂肪肝组(184例),观察临床表现,检测血脂、血糖、体重指数、肝功能等指标并进行分析。结果脂肪肝组血脂、血糖水平、体重指数明显增高,和非脂肪肝组比较差异有显著性(P相似文献   

银杏外种皮多糖对SGC-7901细胞p53基因的表达及端粒酶活性的影响

目的　研究银杏外种皮多糖对人胃癌SGC 790 1细胞 p5 3基因表达及端粒酶活性的影响。 方法　应用免疫组织化学ABC法检测 p5 3基因的表达 ;应用TRAP ELISA法检测端粒酶活性。结果　银杏外种皮多糖 (80～ 16 0mg·L-1,4 8h)能抑制人胃癌SGC 790 1细胞突变型 p5 3基因的表达及其端粒酶活性。结论　银杏外种皮多糖抑制SGC 790 1细胞增殖的作用机制可能与其下调突变型 p5 3基因的表达和对端粒酶活性的抑制作用有关