全文获取类型
收费全文 | 1923篇 |
免费 | 438篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 80篇 |
儿科学 | 45篇 |
妇产科学 | 67篇 |
基础医学 | 127篇 |
口腔科学 | 88篇 |
临床医学 | 559篇 |
内科学 | 393篇 |
皮肤病学 | 15篇 |
神经病学 | 364篇 |
特种医学 | 87篇 |
外科学 | 270篇 |
综合类 | 21篇 |
预防医学 | 110篇 |
眼科学 | 14篇 |
药学 | 68篇 |
肿瘤学 | 63篇 |
出版年
2023年 | 55篇 |
2022年 | 18篇 |
2021年 | 38篇 |
2020年 | 58篇 |
2019年 | 49篇 |
2018年 | 72篇 |
2017年 | 112篇 |
2016年 | 93篇 |
2015年 | 112篇 |
2014年 | 117篇 |
2013年 | 142篇 |
2012年 | 73篇 |
2011年 | 61篇 |
2010年 | 90篇 |
2009年 | 128篇 |
2008年 | 77篇 |
2007年 | 68篇 |
2006年 | 58篇 |
2005年 | 55篇 |
2004年 | 48篇 |
2003年 | 43篇 |
2002年 | 46篇 |
2001年 | 50篇 |
2000年 | 47篇 |
1999年 | 46篇 |
1998年 | 49篇 |
1997年 | 36篇 |
1996年 | 30篇 |
1995年 | 19篇 |
1994年 | 26篇 |
1993年 | 17篇 |
1992年 | 42篇 |
1991年 | 35篇 |
1990年 | 20篇 |
1989年 | 29篇 |
1988年 | 24篇 |
1987年 | 31篇 |
1986年 | 25篇 |
1985年 | 24篇 |
1984年 | 16篇 |
1983年 | 16篇 |
1982年 | 14篇 |
1980年 | 10篇 |
1979年 | 10篇 |
1976年 | 10篇 |
1973年 | 13篇 |
1972年 | 14篇 |
1969年 | 9篇 |
1967年 | 9篇 |
1966年 | 10篇 |
排序方式: 共有2371条查询结果,搜索用时 15 毫秒
91.
Physical therapists are trained and obligated to deliver optimal health care and put patients first above all else. In the changing health-care environment, health-care organizations are grappling with controlling cost and increasing revenues. Moral distress may be created when physical therapists’ desire to provide optimal care conflicts with their organization’s goals to remain financially viable or profitable. Moral distress has been associated with low perception of ethical environment, professional burnout, and high turnover in organizations. This study identified groups who may be vulnerable to low perception of organizational ethical environment and identified self-reported strategies to remedy these perceptions. An ethics environment questionnaire was mailed to a random sample of 1200 physical therapists in Georgia. Respondents (n = 340) were analyzed by age, workplace setting, and position in organization. Therapists working in skilled nursing/assisted living environments scored the lowest on the questionnaire and voiced concerns regarding their ethical work environments. Owners and executives perceived their organizations to be more ethical than front-line clinicians. Respondent concerns included high productivity standards, aggressive coding/billing policies, decreased reimbursement, and increased insurance regulation. Possible solutions included more frequent communication between management and clinicians about ethics, greater professional autonomy, and increased training in business ethics and finance. 相似文献
92.
Site-directed mutagenesis of platelet glycoprotein Ib alpha demonstrating residues involved in the sulfation of tyrosines 276, 278, and 279
下载免费PDF全文
![点击此处可从《Blood》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The interaction between platelet glycoprotein (GP) Ib alpha and von Willebrand factor (VWF) is essential for initiation of hemostasis. The sulfation of the 3 tyrosine residues 276, 278, and 279 in GPIb alpha is an important posttranslational modification that seems to promote the interaction with VWF. The environment where sulfation of tyrosines occurs has been proposed to contain highly acidic residues. This investigation has examined the highly acidic region from Asp249 to Asp287 in the mature GPIb alpha protein. Changes to most of the carboxylic acids in this region resulted in decreased reactivity to VWF. Only 3 mutants (Glu270Gln, Asp283Asn, Asp283Asn/Glu285Gln/Asp287Asn) resulted in the abolition of sulfation. Two novel mutations were also created. First, a deletion of the 7 amino acids from Tyr276 to Glu282 led to a loss of sulfation and totally abolished VWF binding in the presence of botrocetin. This confirms that it is these 3 tyrosines that undergo sulfation and that this region is crucial for botrocetin-mediated VWF binding. The second mutation involves changing the lysine residues at 253, 258, and 262 to alanine. This also led to distinct changes in VWF binding and abolition of sulfation. 相似文献
93.
No association between apolipoprotein E or N‐Acetyltransferase 2 gene polymorphisms and age‐related hearing loss
下载免费PDF全文
![点击此处可从《The Laryngoscope》网站下载免费的PDF全文](/ch/ext_images/free.gif)
94.
13C NMR studies of acetate metabolism during sporulation of Saccharomyces cerevisiae. 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J R Dickinson I W Dawes A S Boyd R L Baxter 《Proceedings of the National Academy of Sciences of the United States of America》1983,80(19):5847-5851
The sporulation of Saccharomyces cerevisiae in the presence of [2-13C]acetate was studied by 13C NMR spectroscopy. The fate of 13C label was analyzed in vivo and in cell extracts. During the first 4 hr of sporulation the major metabolite produced from [2-13C]acetate utilization was glutamate. From the labeling pattern observed it is concluded that both the tricarboxylic acid cycle and the glyoxylate cycle are operating. After about 4 hr trehalose is made. Comparison of the doublet/singlet ratios for C-1,1(1) and C-6,6(1) of trehalose shows a steady drop in the ratio of C-1, C-2-coupled species over trehalose labeled only at C-1 in the C-1, 2 segment of the molecule. The negative correlation of this ratio with that for the C-5, 6 segment indicates a cycling of glucose through the hexose monophosphate shunt. Subsequently fatty acid biosynthesis commences. Large amounts of saturated fatty acid were made. There were conspicuous differences observed in the metabolism of [2-13C]acetate between sporulating and vegetatively growing cells. 相似文献
95.
96.
Peter A. Smith MD Ken N. Kuo MD Adam N. Graf MS Joseph Krzak PT PhD Ann Flanagan PT Sahar Hassani MS Angela K. Caudill PT Fredrick R. Dietz MD Jose Morcuende MD Gerald F. Harris PE PhD 《Clinical orthopaedics and related research》2014,472(4):1281-1290
Background
Clubfoot can be treated nonoperatively, most commonly using a Ponseti approach, or surgically, most often with a comprehensive clubfoot release. Little is known about how these approaches compare with one another at longer term, or how patients treated with these approaches differ in terms of foot function, foot biomechanics, or quality-of-life from individuals who did not have clubfoot as a child.Questions/purposes
We compared (1) focused physical and radiographic examinations, (2) gait analysis, and (3) quality-of-life measures at long-term followup between groups of adult patients with clubfoot treated either with the Ponseti method of nonsurgical management or a comprehensive surgical release through a Cincinnati incision, and compared these two groups with a control group without clubfoot.Methods
This was a case control study of individuals treated for clubfoot at two separate institutions with different methods of treatment between 1983 to 1987. One hospital used only the Ponseti method and the other mainly used a comprehensive clubfoot release. There were 42 adults (24 treated surgically, 18 treated with Ponseti method) with isolated clubfoot along with 48 healthy control subjects who agreed to participate in a detailed analysis of physical function, foot biomechanics, and quality-of-life metrics.Results
Both treatment groups had diminished strength and motion compared with the control subjects on physical examination measures; however, the Ponseti group had significantly greater ankle plantar flexion ROM (p < 0.001), greater ankle plantar flexor (p = 0.031) and evertor (p = 0.012) strength, and a decreased incidence of osteoarthritis in the ankle and foot compared with the surgical group. During gait the surgical group had reduced peak ankle plantar flexion (p = 0.002), and reduced sagittal plane hindfoot (p = 0.009) and forefoot (p = 0.008) ROM during the preswing phase compared with the Ponseti group. The surgical group had the lowest overall ankle power generation during push off compared with the control subjects (p = 0.002). Outcome tools revealed elevated pain levels in the surgical group compared with the Ponseti group (p = 0.008) and lower scores for physical function and quality-of-life for both clubfoot groups compared with age-range matched control subjects (p = 0.01).Conclusions
Although individuals in each treatment group experienced pain, weakness, and reduced ROM, they were highly functional into early adulthood. As adults the Ponseti group fared better than the surgically treated group because of advantages including increased ROM observed at the physical examination and during gait, greater strength, and less arthritis. This study supports efforts to correct clubfoot with Ponseti casting and minimizing surgery to the joints, and highlights the need to improve methods that promote ROM and strength which are important for adult function.Level of Evidence
Level III, prognostic study. 相似文献97.
Daniel Rhon PT DPT DSc Benjamin Hando PT DSc 《Clinical orthopaedics and related research》2014,472(6):1989-1990
98.
99.
Alice K. Guidera BSc MBChB Patrick J. D. Dawes MBChB FRCS Amy Fong MBBS FRANZCR Mark D. Stringer MS FRCS 《Head & neck》2014,36(7):1058-1068
An accurate understanding of the arrangement of cervical fascia and its associated compartments is essential for differential diagnosis, predicting the spread of disease, and surgical management. The purpose of this detailed review is to summarize the anatomic, clinical, and radiological literature to determine what is known about the arrangement of cervical fascia and to highlight controversies and consensus. The current terminology used to describe cervical fascia and compartments is replete with confusing synonyms and inconsistencies, creating important interdisciplinary differences in understanding. The term “spaces” is inappropriate. A modified nomenclature underpinned by evidence‐based anatomic and radiologic findings is proposed. This should not only enhance our understanding of cervical anatomy but also facilitate clearer interdisciplinary communication. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1058–1068, 2014 相似文献