全文获取类型
收费全文 | 7910篇 |
免费 | 649篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 75篇 |
儿科学 | 296篇 |
妇产科学 | 140篇 |
基础医学 | 1341篇 |
口腔科学 | 117篇 |
临床医学 | 929篇 |
内科学 | 1450篇 |
皮肤病学 | 149篇 |
神经病学 | 927篇 |
特种医学 | 161篇 |
外科学 | 790篇 |
综合类 | 42篇 |
一般理论 | 7篇 |
预防医学 | 951篇 |
眼科学 | 136篇 |
药学 | 557篇 |
中国医学 | 22篇 |
肿瘤学 | 490篇 |
出版年
2024年 | 19篇 |
2023年 | 121篇 |
2022年 | 218篇 |
2021年 | 402篇 |
2020年 | 235篇 |
2019年 | 394篇 |
2018年 | 387篇 |
2017年 | 284篇 |
2016年 | 291篇 |
2015年 | 311篇 |
2014年 | 399篇 |
2013年 | 450篇 |
2012年 | 710篇 |
2011年 | 734篇 |
2010年 | 341篇 |
2009年 | 328篇 |
2008年 | 480篇 |
2007年 | 446篇 |
2006年 | 424篇 |
2005年 | 355篇 |
2004年 | 336篇 |
2003年 | 288篇 |
2002年 | 272篇 |
2001年 | 26篇 |
2000年 | 16篇 |
1999年 | 30篇 |
1998年 | 41篇 |
1997年 | 33篇 |
1996年 | 24篇 |
1995年 | 23篇 |
1994年 | 8篇 |
1993年 | 23篇 |
1992年 | 16篇 |
1991年 | 8篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 11篇 |
1983年 | 5篇 |
1982年 | 9篇 |
1981年 | 8篇 |
1980年 | 11篇 |
1979年 | 4篇 |
1977年 | 6篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1968年 | 2篇 |
排序方式: 共有8580条查询结果,搜索用时 15 毫秒
101.
102.
103.
104.
105.
106.
107.
108.
Paula Grippa Sant’Ana Sabrina Setembre Batah Patrícia Santos Leão Walcy Rosolia Teodoro Sérgio Luiz Borges de Souza Gustavo Augusto Ferreira Mota Danielle Fernandes Vileigas Vitor Loureiro da Silva Dijon Henrique Salomé de Campos Katashi Okoshi Vera Luiza Capelozzi Antonio Carlos Cicogna Alexandre Todorovic Fabro 《Pathophysiology》2018,25(4):373-379
Cardiac remodeling (CR) is a structural change of the heart due to chronic hemodynamic overload related to changes in both myocyte and extracellular matrix (ECM). We investigated that the imbalance of collagen V promotes cardiomyocyte apoptosis that contributes to heart failure and cell death. Aortic stenosis was induced surgically and male Wistar rats were randomized to 18 weeks (Sham 18?w, n?=?12; AoS 18?w, n?=?12) and severe of heart failure (Sham HF, n?=?12; AoS HF, n?=?12) groups. Functional and structural echocardiogram, immunohistochemistry for Ki-67, TUNEL assay and Immunofluorescence for collagen were performed. Our main results were: (1) Progressive reduction of cardiac functional capacity due to cardiac remodeling with decreased eject fraction in heart failure; (2) Imbalance of collagen deposition with increased, crowded and irregular collagen I in situ expression; (3) Dysregulation of dynamic control of collagen fibers with exposed epitopes of collagen V; (4) Additional apoptosis that are dependent to cardiac injury. The collagen V expression in cardiac remodeling is for the first time described and may be related to additional apoptosis and autoimmune response. Our findings suggest a critical role of collagen V in cardiac remodeling to modulate and promote heart failure and death. 相似文献
109.
Alireza Amirsadri Albert Pizzuti Daicia Smith Danielle Duckett Cynthia L. Arfken 《Community mental health journal》2018,54(1):54-57
For people with chronic mental illness, their support system (including direct support staff at group homes) play a key role in ameliorating exacerbations leading to crisis care. However, little information exists on curriculum or training programs focused on reducing exacerbations while promoting compassionate care. We developed, implemented and evaluated such a program that featured role-playing and animated videos supplemented with limited didactics. During development phase, direct support staff reviewed videos and rated them as depicting realistic situations with high acceptability. During implementation, the 6-week course (at least one staff from six different group homes not involved in the development phase) using a 3-month pre-post design found reductions in total number of incident reports and pre-specified outcomes of recipient right complaints, emergency calls, and psychiatric hospitalizations. The program demonstrated acceptability, improved care and better outcomes on some but not all outcomes. Improved training of direct support staff is possible and has positive outcomes. 相似文献
110.
Elizabeth K. Do Elizabeth C. Prom-Wormley Bernard F. Fuemmeler Danielle M. Dick Kenneth S. Kendler Hermine H. Maes 《Substance use & misuse》2018,53(14):2291-2298
Background: Youth tobacco use behaviors are predictive of patterns in adulthood and effect long-term health outcomes. Yet, few studies have examined the effect of initial subjective experiences (ISEs) during first tobacco use, which has been found to be an indicator of individuals. sensitivity to nicotine and vulnerability to dependence. Objective: The present study aimed to determine the prevalence of ISEs across a variety of tobacco products, evaluate the factor structure of ISEs by first tobacco product used, and examine the relationship between ISEs and recent (30-day) use of tobacco products across time, using a university sample. Methods: Exploratory factor analyses were conducted to identify latent factors present with respect to items measuring ISEs with tobacco, separately by tobacco product (e.g. cigarettes, cigars, hookah, e-cigarettes). Factor scores for positive and negative ISEs were calculated. Multiple logistic regression analyses were conducted to examine associations between ISEs and recent use of each tobacco product, adjusted for age at first use, sex, race/ethnicity, and cohort. Results: ISEs differ by the first tobacco product used. Associations between factor scores for positive and negative ISEs and recent use were found across a variety of tobacco products. Overall, positive ISEs were more strongly associated with recent use, relative to negative ISEs. Conclusions: Further research is needed to identify genetic and biological pathways and social contexts influencing initial subjective experiences with tobacco use, in efforts to delay the initiation for tobacco use and reduce risk for continued use among young adults. 相似文献