全文获取类型
收费全文 | 7929篇 |
免费 | 632篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 75篇 |
儿科学 | 296篇 |
妇产科学 | 140篇 |
基础医学 | 1340篇 |
口腔科学 | 117篇 |
临床医学 | 931篇 |
内科学 | 1450篇 |
皮肤病学 | 149篇 |
神经病学 | 927篇 |
特种医学 | 161篇 |
外科学 | 790篇 |
综合类 | 42篇 |
一般理论 | 7篇 |
预防医学 | 951篇 |
眼科学 | 136篇 |
药学 | 558篇 |
中国医学 | 22篇 |
肿瘤学 | 490篇 |
出版年
2024年 | 19篇 |
2023年 | 121篇 |
2022年 | 218篇 |
2021年 | 402篇 |
2020年 | 235篇 |
2019年 | 394篇 |
2018年 | 387篇 |
2017年 | 284篇 |
2016年 | 291篇 |
2015年 | 311篇 |
2014年 | 399篇 |
2013年 | 452篇 |
2012年 | 710篇 |
2011年 | 734篇 |
2010年 | 341篇 |
2009年 | 328篇 |
2008年 | 480篇 |
2007年 | 446篇 |
2006年 | 424篇 |
2005年 | 356篇 |
2004年 | 336篇 |
2003年 | 288篇 |
2002年 | 272篇 |
2001年 | 26篇 |
2000年 | 16篇 |
1999年 | 30篇 |
1998年 | 41篇 |
1997年 | 32篇 |
1996年 | 24篇 |
1995年 | 23篇 |
1994年 | 8篇 |
1993年 | 23篇 |
1992年 | 15篇 |
1991年 | 8篇 |
1990年 | 7篇 |
1989年 | 9篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 11篇 |
1983年 | 5篇 |
1982年 | 9篇 |
1981年 | 8篇 |
1980年 | 11篇 |
1979年 | 4篇 |
1977年 | 6篇 |
1975年 | 6篇 |
1974年 | 4篇 |
1968年 | 2篇 |
排序方式: 共有8582条查询结果,搜索用时 0 毫秒
31.
Franklin Patricia D. Zheng Hua Bond Christina Lavallee Danielle C. 《Quality of life research》2021,30(11):3171-3178
Quality of Life Research - New informatics tools can transform evidence-based information to individualized predictive reports to serve shared decisions in clinic. We developed a web-based system... 相似文献
32.
Jan M. West Danielle C. Humphris D. George Stephenson 《Journal of muscle research and cell motility》1995,16(3):267-284
Summary Long-(SL>6m) and short-sarcomere (SL<4m) fibres were isolated from the claw muscle of the yabby (Cherax destructor) during limb regeneration and at different stages of the moult cycle. Long-sarcomere fibres were more susceptible to the changes resulting from the moult-induced atrophy compared with the short-sarcomere fibres. Signs of atrophy included fibre erosion, loss of myosin filaments, a reduction in the diameter of myosin filaments and changes associated with the Z line. The intracellular structure of the fibres, however, remained intact in both fibre types. Fibres taken immediately prior to ecdysis could not be fully activated with Ca2+ or Sr2+ without breaking. In contrast fibres taken within 4 h after ecdysis could develop and maintain full force when activated by Ca2+ or Sr2+. The results suggest that loss of myofibrillar proteins via the moult-induced atrophy and/or events associated with fibre elongation may occur in the period just prior to ecdysis and that these changes may be responsible for the fibres inability to function during the premoult stage. Results from this study showed that short-sarcomere fibres add sarcomeres by at least two different mechanisms (1) transverse sarcomere splitting and (2) Z line splitting. Long-sarcomere fibres appear to be elongated by mechanism (s) other than those used by short-sarcomere fibres which possibly involve large electron dense structures which are positioned between the myofibrils and within the A and I bands. Results from the regenerating chelae limb bud showed that sarcomeres form from separate units comprising myosin filaments and actin filaments anchored into Z lines respectively. These sub-sarcomeric units then join together to form sarcomeres. Myofibril formation is aided by electron dense regions which are closely associated with the membrane system. These fibres although short in length and still within the non-functional limb bud could be activated by Ca2+ and Sr2+ suggesting that full fibre function exists before the chelae become functional. Regenerating muscle fibres consisted predominately of fibres with short-sarcomeres. 相似文献
33.
34.
Yves Claustre Danielle De Peretti Philippe Brun Christiane Gueudet Nathalie Allouard Richard Alonso Jo?lle Lourdelet André Oblin Gabrielle Damoiseau Dominique Fran?on Marie-Fran?oise Suaud-Chagny Régis Steinberg Mireille Sevrin Hans Schoemaker Pascal George Philippe Soubrié Bernard Scatton 《Neuropsychopharmacology》2003,28(12):2064-2076
SSR181507 ((3-exo)-8-benzoyl-N-[[(2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl]methyl]-8-azabicyclo[3.2.1]octane-3-methanamine monohydrochloride) is a novel tropanemethanamine benzodioxane derivative that possesses high and selective affinities for D2-like and 5-HT(1A) receptors (K(I)=0.8, 0.2, and 0.2 nM for human D(2), D(3), and 5-HT(1A), respectively). In vivo, SSR181507 inhibited [(3)H]raclopride binding to D(2) receptors in the rat (ID(50)=0.9 and 1 mg/kg, i.p. in limbic system and striatum, respectively). It displayed D(2) antagonist and 5-HT(1A) agonist properties in the same concentration range in vitro (IC(50)=5.3 nM and EC(50)=2.3 nM, respectively, in the GTPgammaS model) and in the same dose range in vivo (ED(50)=1.6 and 0.7 mg/kg, i.p. on striatal DA and 5-HT synthesis, respectively, and 0.03-0.3 mg/kg, i.v. on dorsal raphe nucleus firing rate). It selectively enhanced Fos immunoreactivity in mesocorticolimbic areas as compared to the striatum. This regional selectivity was confirmed in electrophysiological studies where SSR181507, given acutely (0.1-3 mg/kg, i.p.) or chronically (3 mg/kg, i.p., o.d., 22 days), increased or decreased, respectively, the number of spontaneous active DA cells in the ventral tegmental area, but not in the substantia nigra. Moreover, SSR181507 increased both basal and phasic DA efflux (as assessed by microdialysis and electrochemistry) in the medial prefrontal cortex and nucleus accumbens, but not in the striatum. This study shows that the combination of D(2) receptor antagonism and 5-HT(1A) agonism, in the same dose range, confers on SSR181507 a unique neurochemical and electrophysiological profile and suggests the potential of this compound for the treatment of the main dimensions of schizophrenia. 相似文献
35.
36.
A. Danielle Iuliano Joan M. Brunkard Tegan K. Boehmer Elisha Peterson Stacey Adjei Alison M. Binder Stacy Cobb Philip Graff Pauline Hidalgo Mark J. Panaggio Jeanette J. Rainey Preetika Rao Karl Soetebier Susan Wacaster ChinEn Ai Vikas Gupta Noelle-Angelique M. Molinari Matthew D. Ritchey 《MMWR. Morbidity and mortality weekly report》2022,71(4):146
37.
Heena Akbar Charles J. T. Radclyffe Daphne Santos Maureen Mopio-Jane Danielle Gallegos 《Nutrients》2022,14(10)
Queensland is home to the largest diaspora of Māori and Pasifika peoples in Australia. They form an understudied population concerning experiences and challenges of food insecurity. This community co-designed research aims to explore the conceptualization of household food security by Māori and Pasifika peoples living in south-east Queensland. Participatory action research and talanoa were used to collect and analyse forty interviews with leaders representing 22 Māori and Pasifika cultural identities in south-east Queensland. Eight key themes emerged that conceptualise food security as an integral part of the culture and holistic health. These themes included: spirituality, identity, hospitality and reciprocity, stigma and shame, expectations and obligations, physical and mental health and barriers and solutions. Addressing food insecurity for collectivist cultures such as Māori and Pasifika peoples requires embracing food sovereignty approaches for improved food security through the co-design of practical solutions that impact social determinants and strengthen existing networks to produce and distribute affordable and nutritious food. 相似文献
38.
39.
40.
Implantation represents the limiting step in governing reproductive outcomes. The process is driven by both embryo and endometrium alike. Minute perturbations in this orchestration lay foundation for pregnancy-associated complications that may manifest throughout the gestational course. Furthermore, placental function dictates many aspects of fetal development inclusive of preeclampsia and intrauterine growth restriction (IUGR). Novel techniques such as Multigate Spectral Doppler Analysis (MSDA) may allow for early detection and diagnosis of potentially deleterious fetal outcomes. 相似文献