全文获取类型
收费全文 | 45504篇 |
免费 | 2915篇 |
国内免费 | 465篇 |
专业分类
耳鼻咽喉 | 804篇 |
儿科学 | 522篇 |
妇产科学 | 619篇 |
基础医学 | 7605篇 |
口腔科学 | 1028篇 |
临床医学 | 3701篇 |
内科学 | 8620篇 |
皮肤病学 | 1869篇 |
神经病学 | 3244篇 |
特种医学 | 3061篇 |
外国民族医学 | 1篇 |
外科学 | 5539篇 |
综合类 | 215篇 |
一般理论 | 9篇 |
预防医学 | 2049篇 |
眼科学 | 927篇 |
药学 | 4685篇 |
中国医学 | 658篇 |
肿瘤学 | 3728篇 |
出版年
2024年 | 36篇 |
2023年 | 338篇 |
2022年 | 1077篇 |
2021年 | 1671篇 |
2020年 | 813篇 |
2019年 | 1143篇 |
2018年 | 1348篇 |
2017年 | 1141篇 |
2016年 | 1683篇 |
2015年 | 2291篇 |
2014年 | 2636篇 |
2013年 | 2944篇 |
2012年 | 4356篇 |
2011年 | 4086篇 |
2010年 | 2503篇 |
2009年 | 2137篇 |
2008年 | 2899篇 |
2007年 | 2613篇 |
2006年 | 2274篇 |
2005年 | 2088篇 |
2004年 | 1638篇 |
2003年 | 1405篇 |
2002年 | 1184篇 |
2001年 | 861篇 |
2000年 | 783篇 |
1999年 | 551篇 |
1998年 | 245篇 |
1997年 | 171篇 |
1996年 | 139篇 |
1995年 | 99篇 |
1994年 | 113篇 |
1993年 | 89篇 |
1992年 | 163篇 |
1991年 | 172篇 |
1990年 | 182篇 |
1989年 | 154篇 |
1988年 | 134篇 |
1987年 | 122篇 |
1986年 | 106篇 |
1985年 | 84篇 |
1984年 | 54篇 |
1983年 | 43篇 |
1982年 | 28篇 |
1981年 | 40篇 |
1979年 | 27篇 |
1978年 | 25篇 |
1977年 | 23篇 |
1975年 | 19篇 |
1971年 | 18篇 |
1970年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
Richard Kim Elaine Tan Emily Wang Amit Mahipal Dung-Tsa Chen Biwei Cao Fadzai Masawi Cindy Machado James Yu Dae Won Kim 《The oncologist》2020,25(12):e1893-e1899
Lessons Learned
- The combination of trametinib and sorafenib has an acceptable safety profile, albeit at doses lower than approved for monotherapy.
- Maximum tolerated dose is trametinib 1.5 mg daily and sorafenib 200 mg twice daily.
- The limited anticancer activity observed in this unselected patient population does not support further exploration of trametinib plus sorafenib in patients with hepatocellular carcinoma.
13.
14.
Yeon Seok Lee June Hyunkyung Lee Jae Eun Choi Joo Young Kim Tae Young Han 《Pediatric dermatology》2021,38(1):290-291
Erythema induratum of Bazin (EIB) is a form of tuberculid resulting from hypersensitivity to tuberculosis antigen. EIB occurs most commonly in middle‐aged women and is not typically seen in children. Here, we present a rare case of EIB, presenting as a chronic nodular panniculitis, in a 10‐year‐old Korean boy. 相似文献
15.
Jae Eun Choi Tyler Werbel Zhenping Wang Chia Chi Wu Tony L. Yaksh Anna Di Nardo 《Journal of dermatological science》2019,93(1):58-64
Background
Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.Objectives
To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.Methods
Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.Results
Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.Conclusions
These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study. 相似文献16.
17.
18.
Clinical usefulness of intraductal ultrasonography for the management of acute biliary pancreatitis 下载免费PDF全文
19.
Fluid is usually restricted during thoracic surgery, and vasoactive agents are often administered to maintain blood pressure. One-lung ventilation (OLV) decreases arterial oxygenation; thus oxygen delivery to the brain can be decreased. In this study, we compared phenylephrine and dopamine with respect to maintaining cerebral oxygenation during OLV in major thoracic surgery.Sixty-three patients undergoing lobectomies were randomly assigned to the dopamine (D) or phenylephrine (P) group. The patients’ mean arterial pressure was maintained within 20% of baseline by a continuous infusion of dopamine or phenylephrine. Maintenance fluid was kept at 5 mL/kg/h. The depth of anesthesia was maintained with desflurane 1MAC and remifentanil infusion under bispectral index guidance. Regional cerebral oxygen saturation (rScO2) and hemodynamic variables were recorded using near-infrared spectroscopy and esophageal cardiac Doppler.The rScO2 was higher in the D group than the P group during OLV (OLV 60 min: 71 ± 6% vs 63 ± 12%; P = 0.03). The number of patients whose rScO2 dropped more than 20% from baseline was 0 and 6 in the D and P groups, respectively (P = 0.02). The D group showed higher cardiac output, but lower mean arterial pressure than the P group (4.7 ± 1.0 vs 3.9 ± 1.2 L/min; 76.7 ± 8.1 vs 84.5 ± 7.5 mm Hg; P = 0.02, P = 0.02). Among the variables, age, hemoglobin concentration, and cardiac output were associated with rScO2 by correlation analysis.Dopamine was superior to phenylephrine in maintaining cerebral oxygenation during OLV in thoracic surgery. 相似文献
20.