全文获取类型
收费全文 | 1338551篇 |
免费 | 112527篇 |
国内免费 | 6371篇 |
专业分类
耳鼻咽喉 | 16707篇 |
儿科学 | 43020篇 |
妇产科学 | 36559篇 |
基础医学 | 183637篇 |
口腔科学 | 36275篇 |
临床医学 | 120692篇 |
内科学 | 278535篇 |
皮肤病学 | 31895篇 |
神经病学 | 110501篇 |
特种医学 | 55538篇 |
外国民族医学 | 274篇 |
外科学 | 210344篇 |
综合类 | 31529篇 |
现状与发展 | 2篇 |
一般理论 | 414篇 |
预防医学 | 106653篇 |
眼科学 | 28087篇 |
药学 | 93714篇 |
5篇 | |
中国医学 | 2227篇 |
肿瘤学 | 70841篇 |
出版年
2018年 | 13379篇 |
2017年 | 10632篇 |
2016年 | 12800篇 |
2015年 | 14298篇 |
2014年 | 19948篇 |
2013年 | 29736篇 |
2012年 | 36241篇 |
2011年 | 38890篇 |
2010年 | 24373篇 |
2009年 | 23905篇 |
2008年 | 36365篇 |
2007年 | 38781篇 |
2006年 | 39902篇 |
2005年 | 38495篇 |
2004年 | 36729篇 |
2003年 | 35822篇 |
2002年 | 33833篇 |
2001年 | 66054篇 |
2000年 | 67921篇 |
1999年 | 56588篇 |
1998年 | 16723篇 |
1997年 | 15017篇 |
1996年 | 16014篇 |
1995年 | 16233篇 |
1994年 | 15100篇 |
1993年 | 14155篇 |
1992年 | 47098篇 |
1991年 | 45749篇 |
1990年 | 43973篇 |
1989年 | 41817篇 |
1988年 | 38758篇 |
1987年 | 38082篇 |
1986年 | 35859篇 |
1985年 | 34635篇 |
1984年 | 26359篇 |
1983年 | 22108篇 |
1982年 | 13847篇 |
1981年 | 12447篇 |
1980年 | 11718篇 |
1979年 | 23545篇 |
1978年 | 17072篇 |
1977年 | 14385篇 |
1976年 | 13183篇 |
1975年 | 13723篇 |
1974年 | 16094篇 |
1973年 | 15397篇 |
1972年 | 14173篇 |
1971年 | 13036篇 |
1970年 | 11880篇 |
1969年 | 11101篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Steven J Lobritto Philip Rosenthal Rene Bouw Mimi Leung Paul Snell Richard D Mamelok 《Liver transplantation》2007,13(11):1570-1575
There are few pharmacokinetic data for mycophenolate mofetil (MMF) when used in combination with cyclosporine (CsA) in pediatric liver transplant recipients. The aim of this study was to assess the pharmacokinetics of MMF in stable pediatric liver transplant patients and estimate the dose of MMF required to provide a mycophenolic acid (MPA) exposure similar to that observed in adult liver transplant recipients receiving the recommended dose of MMF (target area under the plasma concentration-time curve from 0 to 12 hours [AUC(0-12)] for MPA of 29 mug.hour/mL in the immediate posttransplantation period and 58 microg x hour/mL after 6 months). A 12-hour pharmacokinetic profile was collected for 8 pediatric patients (mean age 20.9 months) on stable doses of MMF and CsA who had received a liver transplant > or = 6 months prior to entry and who had started on MMF within 2 weeks of transplantation. Mean MMF dosage was 285 mg/m(2) (range, 200-424 mg/m(2)). Of 8 patients, 7 had a MPA AUC(0-12) (range, 11.0-37.2 microg x hour/mL) well below the target. One patient had an AUC(0-12) > or = 58 microg x hour/mL but was considered an outlier and was excluded from analyses. Mean MPA AUC(0-12) and maximum plasma concentration values were 22.7 +/- 10.5 microg x hour/mL and 7.23 +/- 3.27 microg/mL, respectively; values normalized to 600 mg/m(2) (the approved pediatric dose in renal transplantation) were 47.0 +/- 21.8 microg x hour/mL and 14.5 +/- 4.21 microg/mL. In conclusion, assuming that MPA exhibits linear pharmacokinetics, when used in combination with CsA, a MMF dose of 740 mg/m(2) twice daily would be recommended in pediatric liver transplant recipients to achieve MPA exposures similar to those observed in adult liver transplant recipients. This finding should be confirmed by a prospective trial. 相似文献
992.
993.
K Parsi T Exner D E Connor D D F Ma J E Joseph 《European journal of vascular and endovascular surgery》2007,34(6):731-740
OBJECTIVES: To investigate the in vitro effects of Sodium Tetradecyl Sulphate (STS) and Polidocanol (POL) on clotting tests, clotting factors, platelets and microparticles. MATERIALS AND METHODS: Platelet rich (PRP) and platelet poor (PPP) plasmas were incubated with varying concentrations of STS and POL. Clotting tests, platelet/plasma turbidity, and microparticle studies were performed. Specimens were mixed with individual factor deficient plasmas and clotting factor activities were studied. RESULTS: STS at high concentrations (>0.3%) destroyed platelets, microparticles and the clotting factors V, VII and X. It prolonged all clotting tests including prothrombin time (PT), activated partial thromboplastin time (APTT), non-activated partial thromboplastin time (NAPTT), thrombin time (TT), factor Xa clotting time (XACT) and surface activated clotting time (SACT). Higher concentrations of POL were required to achieve some anticoagulant activity. Low sclerosant concentrations shortened XACT and SACT, and induced release of procoagulant platelet derived microparticles. Increased exposure time resulted in increased procoagulant activity. STS at concentrations higher than 0.5% precipitated a complex containing apolipoprotein b and fibrinogen. CONCLUSIONS: Detergent sclerosants affect the clotting mechanism by interfering with clotting factor activities, procoagulant phospholipids and platelet derived microparticles. STS has more anticoagulant activity than POL in high concentrations. Low concentration sclerosants demonstrate procoagulant activity. 相似文献
994.
BACKGROUND: According to the Center for Disease Control and Prevention (CDC), an estimated 30 million people ride horses each year in the United States. Horseback riding related injuries are common, with an estimated 50,000 emergency room visits annually. The popularity of recreational horseback riding has increased in South Florida and the incidence of associated traumatic injuries is a reflection of this. MATERIAL AND METHODS: Retrospective review of patients admitted to a state designated Level I trauma center that sustained horseback riding associated injuries between January 2000 and December 2003. Information extracted from the Trauma Center's data base included demographics, mechanism of injury and toxicology screening. RESULTS: During the review period, twenty-seven patients were identified. There were 12 men and 15 women. The average age was 36 years. The injuries occurred during pleasure riding in 23 patients and thoroughbred related activities in 4 patients. Multiple severe injuries were common and documented in 24 patients. All patients required hospitalization with an average stay of 5 days. Five patients had a positive toxicology screen on admission. No deaths were documented in this review. CONCLUSION: Horseback riding related injuries tends to be serious. Alcohol and recreational drugs may contribute to exacerbate the extent of these injuries. The use of proper protective equipment, instructions for safe riding, and discouraging drug and alcohol use during riding activities should be emphasized. 相似文献
995.
P. Neary C. Hurson D. O. Briain A. Brabazon D. Mehigan T. V. Keaveny S. Sheehan 《Colorectal disease》2007,9(2):166-172
OBJECTIVE: Colonic infarction is a recognized complication of abdominal aortic aneurysm (AAA) surgery. The clinical difficulty in establishing the diagnosis combined with the patient's poor physiological status is usually associated with a fatal outcome. We assessed our experience with this problem to identify a possible risk factor profile for these patients. METHOD: Patients records were identified from the operative logs, intensive care unit, Hospital Inpatient Enquiry system and vascular unit databases over a 6-year period. RESULTS: A total of 405 patients underwent AAA repair during this period; 140 as emergency ruptures. Nine patients were identified from the databases with known colonic infarction (2.2%). One was a woman. The mean age was 70 years. Seven patients had emergency ruptures (5%). Twenty independent risk factors were analysed using univariate and multivariate logistic regression models. Significant risk factors identified by using a multivariate analysis included the nature of the presenting patient, preoperative hypotension, prolonged cross-clamp time, intra-operative ischaemia and postoperative acidosis. Confirmatory diagnosis was made by colonoscopy in eight patients. One patient survived following the salvage surgery. The mean duration of survival was 10.5 days. The overall mortality was 89% of patients. CONCLUSION: In our unit infrarenal AAA repair has a 2.2% rate of colonic infarction. A definitive diagnosis is best made by colonoscopy. A risk factor profile for the development of colonic infarction may be constructed on the basis of specific clinical parameters. Earlier intervention on the basis of this profile may ultimately reduce the current excessive mortality. 相似文献
996.
Presentations of acute appendicitis represent an ongoing challenge to surgeons. This case of retrocaecal perforated appendicitis presented clinically as a right lumbar abscess, with the concomitant new diagnosis of type 2 diabetes mellitus in a 66-year-old male. This case emphasises the importance of an abdominal CT scan in any patient presenting with unusual sepsis near the abdomen. 相似文献
997.
998.
999.
1000.