全文获取类型
收费全文 | 1358395篇 |
免费 | 116579篇 |
国内免费 | 6390篇 |
专业分类
耳鼻咽喉 | 16955篇 |
儿科学 | 43836篇 |
妇产科学 | 37041篇 |
基础医学 | 186366篇 |
口腔科学 | 36630篇 |
临床医学 | 123664篇 |
内科学 | 282092篇 |
皮肤病学 | 32303篇 |
神经病学 | 112728篇 |
特种医学 | 56120篇 |
外国民族医学 | 275篇 |
外科学 | 213265篇 |
综合类 | 31897篇 |
现状与发展 | 2篇 |
一般理论 | 436篇 |
预防医学 | 109494篇 |
眼科学 | 28461篇 |
药学 | 95361篇 |
5篇 | |
中国医学 | 2264篇 |
肿瘤学 | 72169篇 |
出版年
2018年 | 14123篇 |
2017年 | 11136篇 |
2016年 | 13287篇 |
2015年 | 14844篇 |
2014年 | 20704篇 |
2013年 | 30823篇 |
2012年 | 37791篇 |
2011年 | 40492篇 |
2010年 | 25282篇 |
2009年 | 24694篇 |
2008年 | 37603篇 |
2007年 | 40043篇 |
2006年 | 41119篇 |
2005年 | 39648篇 |
2004年 | 37777篇 |
2003年 | 36811篇 |
2002年 | 34780篇 |
2001年 | 66464篇 |
2000年 | 68270篇 |
1999年 | 56909篇 |
1998年 | 16895篇 |
1997年 | 15156篇 |
1996年 | 16177篇 |
1995年 | 16348篇 |
1994年 | 15224篇 |
1993年 | 14256篇 |
1992年 | 47330篇 |
1991年 | 45973篇 |
1990年 | 44206篇 |
1989年 | 42017篇 |
1988年 | 38920篇 |
1987年 | 38263篇 |
1986年 | 35990篇 |
1985年 | 34789篇 |
1984年 | 26506篇 |
1983年 | 22216篇 |
1982年 | 13958篇 |
1981年 | 12529篇 |
1980年 | 11799篇 |
1979年 | 23661篇 |
1978年 | 17177篇 |
1977年 | 14460篇 |
1976年 | 13247篇 |
1975年 | 13767篇 |
1974年 | 16176篇 |
1973年 | 15461篇 |
1972年 | 14216篇 |
1971年 | 13095篇 |
1970年 | 11923篇 |
1969年 | 11167篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
281.
282.
Anand Dayama Nikolaos Tsilimparis Stephen Kolakowski Nathaniel M. Matolo Misty D. Humphries 《Journal of vascular surgery》2019,69(1):156-163.e1
Background
Chronic limb-threatening ischemia (CLTI), defined as ischemic rest pain or tissue loss secondary to arterial insufficiency, is caused by multilevel arterial disease with frequent, severe infrageniculate disease. The rise in CLTI is in part the result of increasing worldwide prevalence of diabetes, renal insufficiency, and advanced aging of the population. The aim of this study was to compare a bypass-first with an endovascular-first revascularization strategy in patients with CLTI due to infrageniculate arterial disease.Methods
We reviewed the American College of Surgeons National Surgical Quality Improvement Program targeted lower extremity revascularization database from 2012 to 2015 to identify patients with CLTI and isolated infrageniculate arterial disease who underwent primary infrageniculate bypass or endovascular intervention. We excluded patients with a history of ipsilateral revascularization and proximal interventions. The end points were major adverse limb event (MALE), major adverse cardiovascular event (MACE), amputation at 30 days, reintervention, patency, and mortality. Multivariable logistic regression was used to determine the association of a bypass-first or an endovascular-first intervention with outcomes.Results
There were 1355 CLTI patients undergoing first-time revascularization to the infrageniculate arteries (821 endovascular-first revascularizations and 534 bypass-first revascularizations) identified. There was no significant difference in adjusted rate of 30-day MALE in the bypass-first vs endovascular-first revascularization cohort (9% vs 11.2%; odds ratio [OR], 0.73; 95% confidence interval [CI], 0.50-1.08). However, the incidence of transtibial or proximal amputation was lower in the bypass-first cohort (4.3% vs 7.4%; OR, 0.60; CI, 0.36-0.98). Patients with bypass-first revascularization had higher wound complication rates (9.7% vs 3.7%; OR, 2.75; CI, 1.71-4.42) compared with patients in the endovascular-first cohort. Compared with the endovascular-first cohort, the incidence of 30-day MACE was significantly higher in bypass-first patients (6.9% vs 2.6%; adjusted OR, 3.88; CI, 2.18-6.88), and 30-day mortality rates were 3.23% vs 1.8% (adjusted OR, 2.77; CI, 1.26-6.11). There was no difference in 30-day untreated loss of patency, reintervention of treated arterial segment, readmissions, and reoperations between the two cohorts. In subgroup analysis after exclusion of dialysis patients, there was also no significant difference in MALE or amputation between the bypass-first and endovascular-first cohorts.Conclusions
CLTI patients with isolated infrageniculate arterial disease treated by a bypass-first approach have a significantly lower 30-day amputation. However, this benefit was not observed when dialysis patients were excluded. The bypass-first cohort had a higher incidence of MACE compared with an endovascular-first strategy. These results reaffirm the need for randomized controlled trials, such as the Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL-2) trial and Best Endovascular vs Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST-CLI), to provide level 1 evidence for the role of endovascular-first vs bypass-first revascularization strategies in the treatment of this population of challenging patients. 相似文献283.
284.
Modena Débora Aparecida Oliveira Miranda Ana Carolina Godoy Grecco Clovis Liebano Richard Eloin Cordeiro Raquel Cristina Tancsik Guidi Renata Michelini 《Lasers in medical science》2020,35(4):797-806
Lasers in Medical Science - Using light sources in phototherapy has presented promising results regarding several types of facial and body skin affections for centuries. The neodymium-doped yttrium... 相似文献
285.
Which infants with eczema are at risk of food allergy? Results from a population‐based cohort
下载免费PDF全文
![点击此处可从《Clinical and experimental allergy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
286.
287.
H N David M Dhilly M Degoulet G Poisnel C Meckler N Vallée J-é Blatteau J-J Risso M Lemaire D Debruyne J H Abraini 《Translational psychiatry》2015,5(7):e594
We investigated the effects of the noble gas argon on the expression of locomotor sensitization to amphetamine and amphetamine-induced changes in dopamine release and mu-opioid neurotransmission in the nucleus accumbens. We found (1) argon blocked the increase in carrier-mediated dopamine release induced by amphetamine in brain slices, but, in contrast, potentiated the decrease in KCl-evoked dopamine release induced by amphetamine, thereby suggesting that argon inhibited the vesicular monoamine transporter-2; (2) argon blocked the expression of locomotor and mu-opioid neurotransmission sensitization induced by repeated amphetamine administration in a short-term model of sensitization in rats; (3) argon decreased the maximal number of binding sites and increased the dissociation constant of mu-receptors in membrane preparations, thereby indicating that argon is a mu-receptor antagonist; (4) argon blocked the expression of locomotor sensitization and context-dependent locomotor activity induced by repeated administration of amphetamine in a long-term model of sensitization. Taken together, these data indicate that argon could be of potential interest for treating drug addiction and dependence. 相似文献
288.
Martin J. Kurian Peter J. Rentzepis Ann M. Carracher Kelly L. Close 《Journal of Diabetes》2019,11(9):700-702
Martin J. Kurian, Peter J. Rentzepis, Ann M. Carracher, and Kelly L. Close are of Close Concerns ( http://www.closeconcerns.com ), a healthcare information company focused exclusively on diabetes and obesity care. Close Concerns publishes Closer Look, a periodical that brings together news and insights in these areas. Each month, the Journal of Diabetes includes this News feature, in which Kurian, Rentzepis, Carracher, and Close review the latest developments relevant to researchers and clinicians. 相似文献
289.
290.