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643.
Bonnet D Angyalosi G Demory A Santraine V Boulet A Spriet C Héliot L Gras-Masse H Grandjean C 《Molecular pharmaceutics》2005,2(5):420-427
The selective delivery of antigens to professional antigen-presenting cells represents a promising approach to improve vaccine efficacy. Addition of a glycoamphiphile to a lipopeptide, whose interest for vaccination is now well-established, greatly favors its solubilization in aqueous solutions through the formation of mixed vesicles. Flow cytometry experiments indicate that this formulation does not diminish the uptake of the lipopeptide by the dendritic cells (DCs). These preliminary results suggest a possible straightforward, noncovalent targeting of cocktail-lipopeptide vaccines to the DCs via carbohydrate receptor-mediated endocytosis. 相似文献
644.
We have conducted a survey of doping among soccer players in C?te d'Ivoire with a representative sample of 150 soccer players who filled out an anonymous questionnaire. The aim of this survey was to get a clearer picture of doping in Ivorian soccer in order to suggest preventive actions against doping. The results of this study showed that doping was known by the Ivorian soccer players; about 18.7% admitted to the use of doping substances, 42% recognised that they felt tempted by doping, while 38% knew another soccer player who had already used a doping substance. Government and sports organisations should recognize the importance of education and information in the antidoping campaign and agree on effective preventive as well as repressive strategies. 相似文献
645.
THE DENVER DEVELOPMENTAL SCREENING TEST 总被引:1,自引:1,他引:0
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647.
FasL-transfected endothelial cells decrease the proliferative response of allogeneic PBL 总被引:2,自引:0,他引:2
Cappellesso S Thibault G Hoarau C Hérault O Iochmann S Bardos P Lebranchu Y 《Transplant immunology》2002,10(4):293-302
Graft endothelium has a key role in organ transplantation because it regulates graft infiltration by allogeneic activated T cells. Overexpression of death molecules that could induce apoptosis of alloreactive T cells might be an alternative to the immunosuppressive treatment currently used in graft transplantation. Several studies have shown that immune-privileged sites express Fas ligand (FasL) and induce apoptosis of activated T-cells. We propose that endothelial cells engineered to express FasL could inhibit alloreactive T cell-proliferation by inducing apoptosis. An expression vector was constructed with human FasL cDNA and used to transfect an endothelial cell line (ECV304 cells). We demonstrated that FasL-transfected ECV304 cells were effective in inducing apoptosis of Jurkat T cell lymphoma as an agonist anti-Fas antibody. Using a mixed lymphocyte-endothelial cell culture model we observed that FasL-transfected ECV304 cells which conserved their two principal costimulatory pathways inhibited alloreactive T cell-proliferation by inducing activated T-cell apoptosis. These results suggest that endothelial cells could be interesting candidates to convey a death signal and induce hyporesponsiveness of alloreactive T cells during organ transplantation. 相似文献
648.
Gustave Savourey Cyrille Moirant Jacqueline Eterradossi Jacques Bittel 《European journal of applied physiology》1995,70(6):469-476
The aim of this study was to clarify the relationships between acute mountain sickness (AMS), studied during an expedition in the Andes, and some physiological parameters determined before the expedition, i.e. biometrical characteristics of the subjects [maximal oxygen consumption (
) body fat content, body mass index], functional pulmonary tests (forced vital capacity, forced expiratory volume at the first second), ventilatory or cardiac responses measured at 4 500 m [hypoxic ventilatory responses (HVR) 4 500 and hypoxic cardiac responses (HCR) 4 500, respectively), cold pressor responses. To achieve this objective, 11 subjects were firstly submitted to a hypobaric poïkilocapnic hypoxic test (589 hPa, 4 500 m) at rest and during exercise to study minute volume, respiratory frequency, end tidal partial pressure of O2 (P
ETO2) and CO2, HVR 4 500, HCR 4 500 and to a cold pressor test of the hand (5 min in 5°C cold water) to study heart rate, blood pressure and skin temperature changes. The AMS was assessed daily by questionnaire during a 12-day expedition in the Andes following both Hackett's method and Environmental Symptoms Questionnaire (modified ESQ 11). Maximal AMS-Hackett score, maximal AMS-ESQ score and mean AMS-ESQ score were defined. The quantifications of AMS following the two methods were correlated. No significant relationships were observed between mean AMS-ESQ score and the biometrical characteristics of the subjects, the functional pulmonary tests, HVR 4 500, HCR 4 500 or the cold pressor responses. However, it appeared that the mean AMS-ESQ score was correlated withP
ETO2 measured at rest and during exercise (50%
) both in hypoxia and normoxia. A closer linear relationship was observed during the exercise in normoxia (r = – 0.92,P < 0.0001). These results could suggest that AMS was related to a relative alveolar hypoventilation more in relation to breathing pattern than HVR. 相似文献
649.
Until 2007, frontline chemotherapy with melphalan and prednisone (MP) was considered as the standard of care in the treatment of elderly patients with multiple myeloma (MM). Recently, several prospective randomized studies comparing MP with the same combination plus new agents such as thalidomide (MPT) or bortezomib (MPV) clearly showed that MPT and MPV were superior to MP in terms of progression-free and overall survival. Melphalan–prednisone–lenalidomide (MPR) is currently compared to MP in one prospective trial and will also probably be superior to MP. Lenalidomide plus low-dose dexamethasone is a promising combination. Thus, at least four highly active new treatment options are now available to treat elderly patients with MM. The goal of future trials will be to determine the best treatment strategy in this group of patients. 相似文献
650.
Ako A Agbor Jean Joel R Bigna Claudia S Plottel Serges Clotaire Billong Mathurin Cyrille Tejiokem Gabriel L Ekali Jean Jacques N Noubiap Roselyne Toby Hermine Abessolo Sinata Koulla-Shiro 《Archives of Public Health》2015,73(1)