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Engmann C Walega P Aborigo RA Adongo P Moyer CA Lavasani L Williams J Bose C Binka F Hodgson A 《Tropical medicine & international health : TM & IH》2012,17(3):272-282
Objective To calculate perinatal mortality (stillbirth and early neonatal death: END) rates in the Upper East region of Ghana and characterize community‐based stillbirths and END in terms of timing, cause of death, and maternal and infant risk factors. Methods Birth outcomes were obtained from the Navrongo Health and Demographic Surveillance System over a 7‐year period. Results Twenty thousand four hundred and ninty seven pregnant women were registered in the study. The perinatal mortality rate was 39 deaths/1000 deliveries, stillbirth rate 23/1000 deliveries and END rates 16/1000 live births. Most stillbirths were 31 weeks gestation or less. Prematurity, first‐time delivery and multiple gestation all significantly increased the odds of perinatal death. Approximately 70% of END occurred during the first 3 postnatal days, and the most common causes of death were birth asphyxia and injury, infections and prematurity. Conclusion Stillbirths and END remain a significant problem in Navrongo. The main causes of END occur during the first 3 days and may be modifiable with simple targeted perinatal policies. 相似文献
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Kristen I. Barton Taryn E. Ludwig Yamini Achari Nigel G. Shrive Cyril B. Frank Tannin A. Schmidt 《Journal of orthopaedic research》2013,31(10):1549-1554
The objective of this study was to determine changes in (1) proteoglycan 4 (PRG4) and hyaluronan (HA) concentration, (2) HA molecular weight (MW) distribution, and (3) cartilage boundary lubricating ability of synovial fluid (SF) from surgical sham (SHAM), anterior cruciate ligament (ACL)/medial collateral ligament (MCL) transection, and lateral meniscectomy (MEN) in a post‐knee surgery ovine model. Ovine SF (oSF) was collected at euthanization 20 weeks after surgery, with the contralateral joint serving as the non‐operative control. PRG4 and HA concentration in oSF was measured by sandwich enzyme‐linked immunosorbent assay, and HA MW distribution by agarose gel electrophoresis. Cartilage boundary lubricating ability of oSF was measured by a cartilage–cartilage friction test. PRG4 and HA concentration in SHAM, ACL/MCL, and MEN oSF were similar in comparison to the contralateral control (CTRL) oSF. The HA MW distribution in the operated oSF for all ranges were similar to the respective CTRL oSF. The kinetic coefficients of friction in operated and CTRL oSF were similar in all groups, and were significantly lower than saline. These results indicate oSF lubricant composition and function at 20 weeks post‐knee surgery were similar to contralateral CTRL, and suggest earlier time points post surgery warrant further investigation. © 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:1549–1554, 2013 相似文献
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Ravindra Gudena Mohammad Atarod Pilambaraei Jason Werle Nigel G. Shrive Cyril B. Frank 《The Journal of arthroplasty》2013
Excessive tibial component overhang during unicompartmental knee arthroplasty (UKA) may cause medial collateral ligament (MCL) impingement, which, in turn, may lead to medial knee pain [Chau et al. Tibial component overhang 226 following unicompartmental knee replacement—does it matter? The Knee. 2009;16(5):310-3]. This study examines MCL loads in 6 human cadaveric knees for different levels of overhang using a robotic testing system. The results indicated no statistically significant difference between the baseline MCL load (no overhang) and the 2-mm overhang (P = .261). However, there were significant differences in MCL load between 2- vs 4-mm (P = .012) and 2- vs 6-mm overhang (P = .022). The loads were almost doubled from 2 to 4 mm of overhang. We conclude that, to minimize pain from excessive MCL loading, surgeons should avoid tibial component overhang greater than 2 mm in unicompartmental knee arthroplasties. 相似文献
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Veronika Válková Jaroslav Polák Marketa Marková Antonin Vítek Hana Hájková Cyril Šálek Bohumil Procházka Petr Cetkovský Marek Trněný 《Clinical transplantation》2013,27(1):E21-E29
Overall 42 patients (pts) transplanted in hematological CR1 were retrospectively analyzed. Median follow‐up was 15 months (range 2–77). The expression of WT1 gene was measured according to the European Leukaemia Net recommendations. At the time of allogeneic stem cell transplantation (allo‐SCT) 29 pts were WT1‐negative and 13 pts were WT1‐positive. In the univariate analysis, significantly better results were observed in the group of WT1 neg in terms of progression‐free survival (in three yr 77% vs. 27%, p = 0.001). In multivariate analysis, the only significant feature in terms of better OS was WT1 negativity (p = 0.029). Our results show that minimal residual disease status measured by quantitative assessment of WT1 gene in acute myeloid leukemia pts in CR1 significantly affects their future prognosis after allo‐SCT. 相似文献
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Filippo Filicori Cameron Stock Andrew D. Schweitzer Xavier M. Keutgen Maria D. LaGratta Rasa Zarnegar Thomas J. Fahey III 《World journal of surgery》2013,37(1):52-58