全文获取类型
收费全文 | 2333篇 |
免费 | 156篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 47篇 |
妇产科学 | 47篇 |
基础医学 | 398篇 |
口腔科学 | 61篇 |
临床医学 | 238篇 |
内科学 | 426篇 |
皮肤病学 | 18篇 |
神经病学 | 235篇 |
特种医学 | 76篇 |
外科学 | 401篇 |
综合类 | 52篇 |
一般理论 | 2篇 |
预防医学 | 174篇 |
眼科学 | 21篇 |
药学 | 117篇 |
中国医学 | 8篇 |
肿瘤学 | 165篇 |
出版年
2023年 | 20篇 |
2022年 | 42篇 |
2021年 | 96篇 |
2020年 | 56篇 |
2019年 | 52篇 |
2018年 | 72篇 |
2017年 | 60篇 |
2016年 | 68篇 |
2015年 | 79篇 |
2014年 | 108篇 |
2013年 | 129篇 |
2012年 | 180篇 |
2011年 | 187篇 |
2010年 | 81篇 |
2009年 | 109篇 |
2008年 | 146篇 |
2007年 | 123篇 |
2006年 | 106篇 |
2005年 | 136篇 |
2004年 | 124篇 |
2003年 | 98篇 |
2002年 | 101篇 |
2001年 | 18篇 |
2000年 | 9篇 |
1999年 | 16篇 |
1998年 | 26篇 |
1997年 | 14篇 |
1996年 | 13篇 |
1995年 | 14篇 |
1994年 | 10篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1985年 | 5篇 |
1983年 | 8篇 |
1982年 | 5篇 |
1981年 | 9篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1972年 | 5篇 |
1970年 | 6篇 |
1969年 | 7篇 |
1966年 | 5篇 |
1963年 | 6篇 |
1962年 | 6篇 |
1942年 | 4篇 |
1933年 | 5篇 |
1929年 | 5篇 |
排序方式: 共有2501条查询结果,搜索用时 15 毫秒
991.
Marlin S Lacombe D Jonard L Leboulanger N Bonneau D Goizet C de Villemeur TB Cabrol S Houang M Moatti L Feldmann D Denoyelle F 《American journal of medical genetics. Part A》2008,(5):661-664
We report on two sporadic and two familial new cases with sensorineural hearing impairment and ovarian dysgenesis which are the cardinal signs of Perrault syndrome in females. Only one of them has a nervous system defect. We reviewed all the published cases of Perrault syndrome in order to define the clinical variability and to evaluate the frequency of the neurological anomalies in this clinical entity. Moreover we excluded GJB2, POLG, and FOXL2 as candidate genes in Perrault syndrome. 相似文献
992.
993.
994.
During locomotion, muscles are controlled by a network of neurones located in the spinal cord and by supraspinal structures. Alterations in that neuromuscular system have a functional impact, in particular on locomotion. The hindlimb unloading (HU) model in rat has been commonly used to generate disuse since it suppresses the hindlimb loading and limits movements. In consequence, it induces plastic mechanisms in the muscle, the spinal cord and the sensorimotor cortex. The aim of this study was to assess the locomotion in HU rats in two conditions: (1) on a runway and (2) in a challenging situation involving the participation of supraspinal structures (ladder walking). For that purpose, the motor pattern has been investigated by means of 3D motion analysis of the right fore- and hindlimbs as well as electromyographic recording of the soleus and tibialis anterior muscles. The 3D motion results show that HU induces a support-dependent alteration of the kinematics: increased duration of step, stance and swing; increased ankle flexion during stance and hyperextension at toe-off; lower protraction during swing. The electromyographic results show that whatever the support, the flexor and extensor burst duration was longer in HU rats. In addition, results show that ladder exacerbates some effects of HU. As ladder walking is a situation which requires precision, it is suggested that the control of hindlimb movement by supraspinal structures is affected in HU rats. 相似文献
995.
Chloé Angelini MD Christelle Marie Durand PhD Patricia Fergelot MD PhD Julie Deforges MLT Anne Vital MD PhD Patrice Menegon MD Elizabeth Sarrazin MD Rémi Bellance MD Stéphane Mathis MD PhD Victoria Gonzalez MD PhD Mathilde Renaud MD PhD Solène Frismand MD Emmanuelle Schmitt MD Marie Rouanet MD Lydie Burglen MD PhD Brigitte Chabrol MD PhD Béatrice Desnous MD PhD Benoît Arveiler PharmD PhD Giovanni Stevanin PhD Isabelle Coupry PhD Cyril Goizet MD PhD 《Movement disorders》2023,38(11):2103-2115
Background
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is caused by mutations in the C19orf12 gene. MPAN typically appears in the first two decades of life and presents with progressive dystonia-parkinsonism, lower motor neuron signs, optic atrophy, and abnormal iron deposits predominantly in the basal ganglia. MPAN, initially considered as a strictly autosomal recessive disease (AR), turned out to be also dominantly inherited (AD).Objectives
Our aim was to better characterize the clinical, molecular, and functional spectra associated with such dominant pathogenic heterozygous C19orf12 variants.Methods
We collected clinical, imaging, and molecular information of eight individuals from four AD-MPAN families and obtained brain neuropathology results for one. Functional studies, focused on energy and iron metabolism, were conducted on fibroblasts from AD-MPAN patients, AR-MPAN patients, and controls.Results
We identified four heterozygous C19orf12 variants in eight AD-MPAN patients. Two of them carrying the familial variant in mosaic displayed an atypical late-onset phenotype. Fibroblasts from AD-MPAN showed more severe alterations of iron storage metabolism and autophagy compared to AR-MPAN cells.Conclusion
Our data add strong evidence of the realness of AD-MPAN with identification of novel monoallelic C19orf12 variants, including at the mosaic state. This has implications in diagnosis procedures. We also expand the phenotypic spectrum of MPAN to late onset atypical presentations. Finally, we demonstrate for the first time more drastic abnormalities of iron metabolism and autophagy in AD-MPAN than in AR-MPAN. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. 相似文献996.
Marie-Jo Brennstuhl Pauline Audinet Cyril Tarquinio 《Annales médico-psychologiques》2017,175(10):871-876
Objectives
We want to know the effects of virtual exchanges places, on psychological adaptation of women patients to cancer pathology, and especially breast cancer.Patients and methods
A literature review was made. Databases Cairn, Wiley Online Library, Taylor and Francis, ScienceDirect Journal of Medical Internet Research (JMIR), Communication organisation, PubMed Central NCBI, APA PsycNET, EBSCOST, Cross Ref, Oxford Journals, Persee, and Link Springer were explored. We included all quantitative and qualitative studies on the use of technologies and online resources related to cancer, especially breast cancer.Results
Fifty-two articles were selected. Forty only included women with breast cancer and 12 included different types of cancer (breast, prostate, kidney, leukemia…). Most of the studies have reported significant results in terms of psychological adaptation: improved emotional, psychological and general well-being; a decrease in anxiety and stress; a greater optimism; a better quality of life and a better participation in health.Conclusions
Results suggest a positive relationship between spaces of exchange for women patients and outcomes related to their experiences in relation to the disease. 相似文献997.
998.
Bryan J. Heard Yamini Achari May Chung Nigel G. Shrive Cyril B. Frank 《Journal of orthopaedic research》2011,29(8):1185-1192
While impossible in humans, the mechanisms of early cartilage, bone and meniscal damage can be quantified after anterior cruciate ligament (ACL) injury in animal models. We utilized an ovine model to determine if the mRNA expression of inflammatory and degradative molecules (IL‐1β, IL‐6, MMP‐1, 2, 3, and 13) in the synovium correlated to changes in joint tissues 2 weeks post‐ACL surgery, to test the hypothesis that synovial inflammation is a marker of these changes and possibly their originator. Nine “idealized” ACL autografts were performed and compared with three sham and six normal animals. Using validated protocols, early osteophyte formation, articular cartilage, and meniscal damage were quantified. Synovium was harvested and mRNA expression quantified using qPCR. Multiple linear regression analysis (MLRA) was utilized to correlate synovial mRNA expression in treated and contra‐lateral limbs, from all treatment groups with corresponding joint scores. Synovial mRNA expression was significantly elevated in all experimental and sham joints. The MLRA model was a significant predictive tool (p = 0.001, R2 = 0.70) of gross tissue scores with significant contributions from IL‐1β, IL‐6, and MMP‐3. Findings suggest that this set of synovial biomarkers is predictive (p < 0.009) of early gross changes of joint tissues after arthrotomy and likely directly involved in the relevant mechanisms, particularly early osteophyte formation, in vivo. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1185–1192, 2011 相似文献
999.
Steffie Spruijt Francois Jouen Michèle Molina Cyril Kudlinski Jessica Guilbert Bert Steenbergen 《Research in developmental disabilities》2013,34(11):4154-4160
Recent studies show varying results on whether motor imagery capacity is compromised in individuals with cerebral palsy (CP). Motor imagery studies in children predominantly used the implicit hand laterality task. In this task participants judge the laterality of displayed hand stimuli. A more explicit way of studying motor imagery is mental chronometry. This paradigm is based on the comparison between the movement durations of actually performing a task and imagining the same task. The current study explored motor imagery capacity in CP by means of mental chronometry of a whole body task. Movement durations of 20 individuals with CP (mean age = 13 years, SD = 3.6) were recorded in two conditions: actual walking and imagined walking. Six unique trajectories were used that varied in difficulty via manipulation of walking distance and path width. We found no main effect of condition (actual walking versus imagining) on movement durations. Difficulty of the walking trajectory did affect movement durations. In general, this was expressed by an increase in movement durations with increasing difficulty of the task. No interaction between task difficulty and movement condition was found. Our results show that task difficulty has similar effects on movement durations for both actual walking and imagined walking. These results exemplify that the tested individuals were able to use motor imagery in an explicit task involving walking. Previous studies using the implicit hand laterality task showed varying results on motor imagery capacity in CP. We therefore conclude that motor imagery capacity is task dependent and that an explicit paradigm as the one used in this study may reveal the true motor imagery capacity. The implications of these findings for the use of motor imagery training are discussed. 相似文献
1000.
Emmanuel Brard Axel Gorlier Cyril Viarouge Fabien Donnet Corinne Sailleau Claudia Schulz Bernd Hoffmann Loic Comtet Martin Beer Stphan Zientara Damien Vitour 《Transboundary and Emerging Diseases》2019,66(1):537-545
Competitive‐ELISA (c‐ELISA) is the most widely used serological test for the detection of Bluetongue virus (BTV) viral protein 7 (VP7) antibodies (Ab). However, these BTV c‐ELISAs cannot to distinguish between IgG and IgM. IgM Ab are generated shortly after the primary immune response against an infectious agent, indicating a recent infection or exposure to antigens, such as after vaccination. Because the BTV genome or anti‐VP7 Ab can be detected in ruminant blood months after infection, BTV diagnostic tools cannot discriminate between recent and old infections. In this study, we evaluated an IgM‐capture ELISA prototype to detect ruminant anti‐BTV VP7 IgM on 1,650 serum samples from cattle, sheep, or goats. Animals were BTV‐naive, infected, or/and vaccinated with BTV‐1, ‐2, ‐4, ‐8, ‐9, ‐16, or ‐27, and we also included 30 sera from cattle infected with the Epizootic haemorrhagic disease virus (EHDV) serotype 6. Results demonstrated that this ELISA kit is specific and can detect the presence of IgM with satisfactory diagnostic specificity and sensitivity from 1 to 5 weeks after BTV infection in domestic ruminants (for goats and cattle; for sheep, at least up to 24 days). The peak of anti‐VP7 IgM was reached when the level of infectious viruses and BTV RNA in blood were the highest. The possibility of detecting BTV‐RNA in IgM‐positive sera allows the amplification and sequencing of the partial RNA segment 2 (encoding the serotype specific to VP2) to determine the causative BTV serotype/strain. Therefore, BTV IgM ELISA can detect the introduction of BTV (or EHDV) in an area with BTV‐seropositive domestic animals regardless of their serological BTV status. This approach may also be of particular interest for retrospective epidemiological studies on frozen serum samples. 相似文献