全文获取类型
收费全文 | 176篇 |
免费 | 14篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 7篇 |
妇产科学 | 2篇 |
基础医学 | 9篇 |
口腔科学 | 21篇 |
临床医学 | 27篇 |
内科学 | 42篇 |
皮肤病学 | 2篇 |
神经病学 | 2篇 |
特种医学 | 65篇 |
外科学 | 3篇 |
综合类 | 2篇 |
预防医学 | 5篇 |
眼科学 | 1篇 |
药学 | 6篇 |
出版年
2021年 | 1篇 |
2020年 | 1篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 2篇 |
2015年 | 1篇 |
2014年 | 7篇 |
2013年 | 5篇 |
2011年 | 1篇 |
2010年 | 6篇 |
2009年 | 5篇 |
2008年 | 3篇 |
2007年 | 5篇 |
2006年 | 2篇 |
2005年 | 6篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 1篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 7篇 |
1997年 | 12篇 |
1996年 | 11篇 |
1995年 | 11篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 6篇 |
1989年 | 11篇 |
1988年 | 10篇 |
1987年 | 5篇 |
1986年 | 1篇 |
1985年 | 6篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1976年 | 5篇 |
1975年 | 1篇 |
排序方式: 共有195条查询结果,搜索用时 31 毫秒
121.
NN Mahajan NL Gaikwad MV Solomon KN Mahajan NP Kothari 《BJOG : an international journal of obstetrics and gynaecology》2009,116(13):1801-1804
In modern obstetrics, the role of internal podalic version (IPV) is limited to delivery of the second twin. A retrospective study was conducted to assess the efficacy of IPV in singleton neglected shoulder presentation with fetal demise. Women with live fetuses, previous CS or contracted pelvis were excluded. The procedure involved repositioning the prolapsed hand under anaesthetic followed by breech extraction. 12 women were identified over a 19 month period and all underwent successful IPV. One woman had a postpartum haemorrhage. We conclude that, in singleton pregnancies with a transverse lie, IPV has a role to play in the delivery of dead fetuses. 相似文献
122.
123.
Ferrett HL Cuzen NL Thomas KG Carey PD Stein DJ Finn PR Tapert SF Fein G 《Alcoholism, clinical and experimental research》2011,35(9):1705-1715
Background: Individuals who begin drinking during early adolescence and exhibit externalizing pathology and disinhibitory/dysregulatory tendencies are more vulnerable to developing alcohol use disorders (AUDs) in adulthood. Previous research has focused on in‐treatment populations with substantial comorbid psychopathology and polysubstance use. Here, we characterize a unique sample of treatment‐naïve adolescents without such comorbidity to help identify vulnerable youth who may benefit from early intervention. Methods: We compared externalizing propensity, disinhibitory characteristics, and school performance in adolescents with AUDs (but without comorbid psychopathology or other substance use; n = 70) to those of demographically matched controls (n = 70). Within the AUD group, we compared measures of substance use and the disinhibitory syndrome between boys and girls with differing severity of externalizing propensity. Results: Adolescents with AUDs demonstrated more externalizing propensity and disinhibitory personality traits (impulsivity, novelty seeking, and excitement seeking), poorer self‐monitoring and response inhibition, more bullying and sexual risk‐taking behavior, poorer first‐language performance, and greater use of alcohol, cannabis, and nicotine (p < 0.05). Within the AUD group, participants with higher externalizing propensity began drinking earlier, more frequently, and for a longer duration than those with lower externalizing symptoms (p < 0.05). Disinhibitory features (personality, cognition, and behavior) were, however, not stronger in those with higher externalizing propensity. Conclusions: We suggest that the constructs of externalizing propensity and disinhibitory syndrome are useful in characterizing treatment‐naïve adolescents with AUDs but without comorbid psychopathology or polysubstance use. These results support the importance of these constructs in understanding adolescent AUDs, even when the frank externalizing diagnoses of childhood (oppositional defiant disorder and conduct disorder) are excluded. 相似文献
124.
125.
Genetic analysis and functional characterization of prothrombins Corpus Christi (Arg382-Cys), Dhahran (Arg271-His), and hypoprothrombinemia 总被引:3,自引:2,他引:1
O'Marcaigh AS; Nichols WL; Hassinger NL; Mullins JD; Mallouh AA; Gilchrist GS; Owen WG 《Blood》1996,88(7):2611-2618
The structural abnormalities and functional characteristics of dysfunctional prothrombin variants in two new kindreds have been determined. Prothrombin Corpus Christi (family 1) was purified and found to have markedly reduced fibrinogen clotting activity, yet normal amidolytic and near-normal platelet aggregating activity. A transition (C to T) at nucleotide position 8885, present in the heterozygous form in affected family members, resulted in the substitution of Cys for Arg 382. This substitution results in the loss of a positive charge within the fibrinogen-binding exosite of thrombin, thus accounting for the observed functional defect. A heterozygous C to T transition was also present at position 19994 in other family members with a hypoprothrombinemic phenotype. This mutation results in the replacement of Gln 541 (CAA) by a premature stop codon (TAA). Prothrombin Dhahran (family 2) was found to have markedly reduced fibrinogen clotting activity, but normal amidolytic activity. Affected family members were found to have a G to A transition at nucleotide position 7312 resulting in the substitution of His for Arg 271. This substitution results in the abolition of a factor Xa cleavage site, yielding meizothrombin rather than thrombin, on activation of prothrombin Dhahran by factor Xa. All but one of the above mutations occur at CpG dinucleotides, thus further supporting the observation of a high incidence of CpG transitions in hereditary dysprothrombinemia. The significant bleeding tendencies of individuals homozygous for prothrombin Dhahran (prothrombin clotting activity 5% to 7%) contrast sharply with the absence of significant chronic bleeding in the proband expressing prothrombin Corpus Christi (prothrombin clotting activity 2%). Our findings underscore the capacity of thrombin to contribute to clinical hemostasis by mechanisms other than its fibrinogen clotting activity. 相似文献
126.
Association between endometriosis, dysplastic naevi and history of melanoma in women of reproductive age 总被引:1,自引:0,他引:1
Hornstein MD; Thomas PP; Sober AJ; Wyshak G; Albright NL; Frisch RE 《Human reproduction (Oxford, England)》1997,12(1):143-145
Women with melanoma and its precursor lesions, dysplastic naevi, have a
higher prevalence of reproductive disorders than women without melanotic
lesions. This association appears strongest among young women with
dysplastic naevi and endometriosis. The purpose of this study was to
evaluate patients with laparoscopy-confirmed endometriosis for the presence
of dysplastic naevi. A total of 66 endometriosis patients and 35 controls
completed a detailed questionnaire and underwent an extensive
dermatological examination for the presence of dysplastic naevi. In all,
41% of patients aged < or = 32 years had dysplastic naevi, compared with
8% of controls (P = 0.038). In addition, 29% of patients with endometriosis
reported a family history of melanoma compared with 10% of controls (P =
0.039). This study demonstrated an association between endometriosis and
dysplastic naevi in younger women of reproductive age and found an
associated family history of melanoma among endometriosis patients. These
observations may be useful in the evaluation and care of young women by
both gynaecologists and dermatologists.
相似文献
127.
128.
NL Hoenderdos DE Slot S Paraskevas GA Van der Weijden 《International journal of dental hygiene》2008,6(4):280-289
Abstract: Objective: To review the literature on whether a hand‐held triangular woodstick, as compared with no adjunct or other interdental cleaning device in addition to daily toothbrushing, can improve clinical parameters of gingival inflammation. Material and Methods: MEDLINE and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched through February 2008 to identify appropriate studies. Plaque and gingivitis were selected as outcome variables. Results: Independent screening of the titles and abstracts of 181 MEDLINE and 65 CENTRAL papers yielded seven publications with eight clinical experiments that met the eligibility criteria. The improvement in gingival health, as observed in seven studies, represents a significant incremental benefit realized by the use of triangular woodsticks. None of the studies that scored plaque demonstrated any significant advantage to the use of woodsticks, as opposed to alternative methods, in gingivitis patients. Conclusion: Evidence from controlled trials, most of which were also randomized, shows that woodsticks do not have an additional effect on visible interdental plaque or gingival index, but do, however, provide an improvement in interdental gingival inflammation by reducing the bleeding tendency. 相似文献
129.
130.
Quinones RR; Gutierrez RH; Dinndorf PA; Gress RE; Ney AB; Taylor B; Karandish S; Carter CS; Luban NL; Reaman GH 《Blood》1993,82(1):307-317
We report the development of a double-cycle elutriation (DCE) technique separating 3 or greater logs of T cells from a stem-cell-enriched marrow fraction and the results of phase I T-cell depletion studies with HLA-disparate related bone marrow transplantation (BMT) donors in two patient groups. In group 1, 10 patients with refractory hematopoietic malignancies received combination chemotherapy, total body irradiation (TBI), and immunosuppression (pre- and post-BMT), and hematopoietic rescue with a marrow transplant, depleted of T cells by elutriation. Potentially to promote engraftment and a graft-versus- leukemia (GVL) effect, 0.5 to 0.75 x 10(5) T cells/kg were added back. All 10 patients engrafted. Five patients developed acute graft-versus- host disease (GVHD; four grade II, one grade III) and two subsequently developed chronic GVHD. Two patients have relapsed (median follow-up, 206 days; range, 46 to 1,035). Four patients died of BMT-related complications (three of infection, one of veno-occlusive disease [VOD]). Four patient are disease-free survivors (median follow-up, 960 days; range, 670 to 1,035). Group 2 included five infants, four with congenital lymphohematopoietic deficiencies and one with refractory acute lymphocytic leukemia (ALL). In these infants, busulfan and increased cyclophosphamide were substituted for TBI. Only the ALL patient received added T cells. Three patients engrafted: one has stable mixed chimerism, one relapsed with ALL, and one rejected the marrow. One patient had primary autologous recovery, while another failed to engraft. None developed GVHD. We conclude that, in this setting of HLA-disparate BMT with post-BMT antithymocyte globulin (ATG) and corticosteroids, DCE significantly depletes T cells from the marrow and that a defined number of T cells can be added without the occurrence of severe GVHD. 相似文献