Production of the proto-oncogene BAX does not vary with changing in luteal function in women

The mechanisms of luteal maintenance and regression in women are uncertain, but morphological and oligonucleosome studies raise the possibility that apoptosis may be involved. BAX is a proto-oncogene of the BCL-2 family which can induce apoptosis. The aim of this study was to determine whether BAX is expressed in the human corpus luteum and whether the level of expression changes relative to the stage of the luteal phase or in simulated early pregnancy. Carefully timed samples of corpus luteum were studied by immunostaining, sodium dodecyl sulphate-polyacrylamide gel electrophoresis and immunoblotting. BAX protein was immunolocalized in luteal sections from all stages including luteal rescue but BAX production did not change during luteal maintenance or regression. Localization of BAX to the steroid-secreting cells of the corpus luteum implies a functional role and BAX may interact with other members of the BCL-2 family to affect luteal function.      

Distribution of colonic polyps: increased incidence of proximal lesions in older patients

Several recent studies have shown a proximal shift in the distribution of colonic carcinoma compared to older studies. Because of the association between polyps and cancer, the authors evaluated the distribution of colonic polyps in 3,664 consecutive patients who had a colon examination over a period of 14 months. A total of 967 colorectal polyps were found in 633 patients. In all, 502 polyps (52%) were proximal to the rectosigmoid. Older patients had significantly more right-sided polyps and fewer rectosigmoid lesions. Large polyps occurred more frequently in the right colon, and this was also statistically significant. Gender has no effect on polyp distribution. The authors conclude that the importance of screening for polyps, particularly on the right side of the colon, increases with age.     

The malaria vectors of the Lower Shire valley,Malawi

The aim of this study was to characterise breeding sites and climatic factors that influence the abundance of malaria vectors in the Lower Shire valley, Malawi. We regularly sampled adult and larval mosquitoes over the transition periods between the wet and dry seasons during 2000 and 2001. Three potential malaria vectors, An. arabiensis, An. gambine sensu stricto and An. funestus, and a fourth non-vector species An. quadriannulatus, were identified. (This is the first record of An. quadriannulatus in Malawi). These four species bred predominately in larger water bodies, particularly rice paddies, and to a lesser extent in boreholes and puddles. Smaller temporary pools and puddles evaporated too quickly to permit the completion of larval development. Abundance of An. gambiae s.l. was closely associated with minimum temperatures. We discuss the relevance of the findings to malaria vector control in Malawi.     

New South Wales population-based birthweight percentile charts

Objective : To derive newborn percentile charts using NSW population and hospital-based data.
Methodology : Birthweight data for liveborn singleton infants were obtained from the New South Wales Midwives Data Collection (MDC) from 1990 to 1994 inclusive ( n = 422139). Data were also collected from King George V Hospital (KGV) for liveborn singleton infants less than 35 weeks of gestation for 1982-89 inclusive, and for all gestations for 1990-95 inclusive ( n = 30 610). Birthweight percentiles were derived using the MDC data separately for mates and females. Head circumference ( n = 29 090) and birth length percentiles ( n = 26 973) were derived from the KGV data.
Results : The charts derived from MDC data had generally higher percentiles than previously published charts. These represent the largest Australian population-based study published to date.
Conclusions : Periodic review of newborn growth charts is recommended because of changing ethnic and socio-economic factors.