全文获取类型
收费全文 | 24663篇 |
免费 | 1423篇 |
国内免费 | 135篇 |
专业分类
耳鼻咽喉 | 250篇 |
儿科学 | 631篇 |
妇产科学 | 503篇 |
基础医学 | 3691篇 |
口腔科学 | 1043篇 |
临床医学 | 2206篇 |
内科学 | 5728篇 |
皮肤病学 | 670篇 |
神经病学 | 2146篇 |
特种医学 | 563篇 |
外科学 | 2239篇 |
综合类 | 51篇 |
一般理论 | 10篇 |
预防医学 | 2344篇 |
眼科学 | 477篇 |
药学 | 1655篇 |
中国医学 | 112篇 |
肿瘤学 | 1902篇 |
出版年
2024年 | 33篇 |
2023年 | 258篇 |
2022年 | 603篇 |
2021年 | 1025篇 |
2020年 | 612篇 |
2019年 | 823篇 |
2018年 | 932篇 |
2017年 | 646篇 |
2016年 | 774篇 |
2015年 | 847篇 |
2014年 | 1115篇 |
2013年 | 1413篇 |
2012年 | 2207篇 |
2011年 | 2299篇 |
2010年 | 1205篇 |
2009年 | 991篇 |
2008年 | 1690篇 |
2007年 | 1637篇 |
2006年 | 1489篇 |
2005年 | 1374篇 |
2004年 | 1199篇 |
2003年 | 1020篇 |
2002年 | 887篇 |
2001年 | 113篇 |
2000年 | 80篇 |
1999年 | 98篇 |
1998年 | 129篇 |
1997年 | 108篇 |
1996年 | 90篇 |
1995年 | 66篇 |
1994年 | 57篇 |
1993年 | 57篇 |
1992年 | 42篇 |
1991年 | 37篇 |
1990年 | 31篇 |
1989年 | 36篇 |
1988年 | 25篇 |
1987年 | 18篇 |
1986年 | 26篇 |
1985年 | 26篇 |
1984年 | 28篇 |
1983年 | 15篇 |
1982年 | 17篇 |
1981年 | 12篇 |
1980年 | 3篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1975年 | 2篇 |
1974年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Dănilă R Andriescu L Dăscălescu C Lefter LP Popovici R Găluşcă B Vulpoi C Ungureanu C Mogoş V Dragomir C 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》2005,109(4):746-752
The most common clinical presentation of differentiated thyroid cancer (DTC), consisting of papillary and follicular adenocarcinoma (with their histological variants), is the solitary thyroid nodule. A review of the literature is performed in order to describe particular forms of DTC, in terms of incidence, diagnosis and treatment: occult carcinoma, carcinoma on aberrant thyroid tissue, "functional" thyroid carcinoma and familial non-medullary carcinoma. A particular interest is shown to the coexistence of malignancy with benign thyroid diseases, such as goiter, hyperthyroidism and Hashimoto's thyroiditis, as well as parathyroid adenoma. In conclusion, the authors emphasize that the association of carcinoma with benign thyroid conditions is not rare and it substantiate an aggressive approach in regard to diagnosis and treatment, increasing the indication for surgery and, moreover, for total thyroidectomy. 相似文献
992.
Rosiello Giuseppe Knipper Sophie Palumbo Carlotta Dzyuba-Negrean Cristina Pecoraro Angela Mazzone Elio Mistretta Francesco A. Tian Zhe Capitanio Umberto Montorsi Francesco Shariat Shahrokh F. Saad Fred Briganti Alberto Karakiewicz Pierre I. 《International urology and nephrology》2019,51(12):2181-2188
International Urology and Nephrology - We tested the effect of marital status on cytoreductive nephrectomy, metastasectomy, and systemic therapy rates, as well as on cancer-specific mortality (CSM)... 相似文献
993.
994.
Ripoll C 《Journal of clinical gastroenterology》2007,41(Z3):S330-S335
End-stage liver disease is characterized by the development of complications related to portal hypertension. Hepatic venous pressure gradient (HVPG), as an estimation of portal pressure, has been associated to the development of these complications. Most of the data that has been published in this regard is in the context of the development of varices and variceal bleeding. However, HVPG has also been associated to the development or the outcome of other complications of portal hypertension, hepatocellular carcinoma, liver transplantation, and survival. This review analyses the published data regarding the association between the HVPG and the different possible outcomes in cirrhosis. 相似文献
995.
Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association 《World journal of gastroenterology : WJG》2010,16(7):862-867
AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 years.METHODS:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and 1994.GroupⅡincluded 871 patients diagnosed in 2001.RESULTS:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all ... 相似文献
996.
Mirko Mattia Lucie Biehler-Gomez Emanuela Sguazza Paolo Maria Galimberti Folco Vaglienti Daniele Gibelli Pasquale Poppa Giulia Caccia Marco Caccianiga Stefano Vanin Laura Manthey Richard L. Jantz Domenico Di Candia Emanuela Maderna Giuliana Albini Sachin Pawaskar Franklin Damann Anna Maria Fedeli Elena Belgiovine Daniele Capuzzo Fabrizio Slavazzi Cristina Cattaneo 《Medical history》2022,66(1):24
The Ospedale Maggiore, known as Ca’ Granda, was founded in 1456 by will of Francesco Sforza, Duke of Milan, and was considered for almost five centuries a model for Milanese, Italian and even European healthcare. Attracting patients from all over Europe, the Ca’ Granda distinguished itself for the introduction of new treatments and innovative health reforms. In the burial ground of the hospital still lie the bodies of the deceased patients, who came from the poorest strata of the population. The study of their remains aims to give back a general identity and a story to each of these persons as well as reconstruct a fraction of the sixteenth century population of Milano as concerns lifestyle and disease and examine practises and therapy of this exceptional hospital. It is estimated that about two million commingled bones and articulated skeletons rest in the crypt, together with other types of findings (e.g., ceramic, coins, clothing). These remains are the object of a large project involving various disciplines ranging from humanities to hard sciences. The aim of this paper is to bring this historical gem to the attention of scholars and provide a glimpse of what its contents have already revealed. 相似文献
997.
Bogdana Adriana Nasui Andreea Toth Codruta Alina Popescu Ovidiu Nicolae Penes Valentin Nicolae Varlas Rodica Ana Ungur Nina Ciuciuc Cristina Alina Silaghi Horatiu Silaghi Anca Lucia Pop 《Nutrients》2022,14(6)
The study aimed to evaluate lifestyle factors among Information Technology (IT) workers from Romania before and during the pandemic. We used an online applied questionnaire, filled in by 1638 respondents, that assessed nutrition status-Body Mass Index (BMI), weight and diet change, physical activity, alcohol consumption, number of hours working in front of the computer, stress, and sleep. Multivariate logistic regression was used to establish the lifestyle factors that lead to weight gain. Although the level of physical activity (PA) was low before the pandemic, the results of our study showed a further decrease in physical activity. In total, 61.1% of men and 71.1% of women performed PA for less than 30 min per day. Weight gain was reported in 50.5% of men and 45.3% of women (mean weight gain was 5.11 ± 3.52 kg) as a result of increased screen time (with a mean of 3.52 ± 4.29 for females and 3.05 ± 2.09 for males, p > 0.05 h per day) and the reported changes in diet. Despite the popularity of home-cooked foods, the intake of vegetables and fruit remained low. The quality of sleep was poor for 55.7% of the respondents. Public health and corporation policies are required to encourage a healthy lifestyle and avoid chronic diseases. 相似文献
998.
Sánchez-Sixto C Prazeres VF Castedo L Lamb H Hawkins AR González-Bello C 《Journal of medicinal chemistry》2005,48(15):4871-4881
The syntheses by Suzuki cross-coupling of 12 5-aryl analogues of the known inhibitor (1R,3R,4R)-1,3,4-trihydroxycyclohex-5-en-1-carboxylic acid are reported. These compounds were found to be reversible competitive inhibitors against Mycobacterium tuberculosis type II dehydroquinase, the third enzyme of the shikimic acid pathway. The most potent inhibitor, the 3-nitrophenyl derivative, has a K(i) of 54 nM, over 180 times more potent than the reported inhibitor (1R,3R,4R)-5-fluoro-1,3,4-trihydroxycyclohex-5-en-1-carboxylic acid and more than 700 times lower than the K(M) of the substrate, making it the most potent known inhibitor against any type II dehydroquinase. Docking studies using GOLD (version 2.2) indicated a key electrostatic binding interaction between the aromatic rings and Arg19, a residue that has been identified as essential for enzyme activity. 相似文献
999.
Stella Regina Zamuner Juliana Pavan Zuliani Cristina Maria Fernandes José Maria Gutiérrez Catarina de Fátima Pereira Teixeira 《Toxicon》2005,46(7):806-813
Bothrops asper venom (BaV) causes systemic and local effects characterized by an acute inflammatory reaction with accumulation of leukocytes and release of endogenous mediators. In this study, the effects of BaV on the release of the cytokines IL-1, IL-6 and TNF-alpha and the eicosanoids LTB4 and TXA2 in the peritoneal cavity of mice were analyzed. We also investigated the participation of beta2 integrin chain, l-selectin, LFA-1, ICAM-1 and PECAM-1 adhesion molecules in the BaV-induced leukocyte accumulation. Levels of proinflammatory cytokines IL-6 and TNF-alpha, as well as eicosanoids LTB4 and TXA2 were significantly increased after BaV injection (250 microg/kg), whereas no increment in IL-1 was observed. Anti-mouse l-selectin, LFA-1, ICAM-1, PECAM-1 and beta2 integrin chain monoclonal antibodies resulted in a reduction of neutrophil accumulation induced by BaV injection compared with isotype-matched control injected animals. These data suggest that BaV is able to induce the activation of leukocytes and endothelium to express adhesion molecules involved in the recruitment of neutrophils into the inflammed site. Furthermore, these results showed that BaV induces the release of cytokines and eicosanoids in the local of the venom injection; these inflammatory mediators may be important for the initiation and amplification of the inflammatory reaction characteristic from Bothrops sp envenomation. 相似文献
1000.
Maristela Soares Swerts Pereira Marcos A. Rossi Cristina Ribeiro Cardoso João Santana da Silva Léa Assed Bezerra da Silva Milton Carlos Kuga Gisele Faria 《Journal of endodontics》2014