全文获取类型
收费全文 | 2081篇 |
免费 | 160篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 40篇 |
妇产科学 | 15篇 |
基础医学 | 254篇 |
口腔科学 | 48篇 |
临床医学 | 187篇 |
内科学 | 513篇 |
皮肤病学 | 46篇 |
神经病学 | 221篇 |
特种医学 | 115篇 |
外国民族医学 | 1篇 |
外科学 | 366篇 |
综合类 | 5篇 |
一般理论 | 1篇 |
预防医学 | 142篇 |
眼科学 | 19篇 |
药学 | 122篇 |
中国医学 | 8篇 |
肿瘤学 | 139篇 |
出版年
2024年 | 1篇 |
2023年 | 21篇 |
2022年 | 74篇 |
2021年 | 166篇 |
2020年 | 77篇 |
2019年 | 104篇 |
2018年 | 92篇 |
2017年 | 76篇 |
2016年 | 90篇 |
2015年 | 98篇 |
2014年 | 111篇 |
2013年 | 144篇 |
2012年 | 193篇 |
2011年 | 185篇 |
2010年 | 111篇 |
2009年 | 89篇 |
2008年 | 114篇 |
2007年 | 111篇 |
2006年 | 103篇 |
2005年 | 84篇 |
2004年 | 74篇 |
2003年 | 56篇 |
2002年 | 37篇 |
2001年 | 4篇 |
2000年 | 8篇 |
1999年 | 3篇 |
1998年 | 7篇 |
1997年 | 7篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1991年 | 1篇 |
1988年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有2257条查询结果,搜索用时 265 毫秒
91.
92.
93.
94.
95.
Naveed T. Siddiqui MD Cristian Arzola MD Iram Ahmed MD Sharon Davies MD Jose C. A. Carvalho MD PhD 《Journal canadien d'anesthésie》2014,61(8):710-716
Purpose
The objective of this study was to determine the impact of a low-fidelity simulation model on mastering the sterile technique during placement of epidural catheters.Methods
Trainees, including residents and fellows, were given conventional teaching consisting of a lecture and a video demonstration on the appropriate sterile technique to apply during the placement of epidural catheters. The trainees were then provided with a one-on-one demonstration session using a low-fidelity Styrofoam? epidural model, followed by a series of simulation sessions. After conventional teaching and following each simulation session, the trainees were assessed on their performance until competence was achieved based on a 15-point checklist. The retention of competence was subsequently evaluated bi-weekly in clinical practice for four assessments.Results
Twenty-one trainees participated in the study. The average score for the residents following conventional teaching was 6.0 out of 15 points on the checklist. Following the initial one-on-one hands-on demonstration, the average score increased to 10.8 (difference = 4.8, 95% confidence interval (CI): 3.3 to 6.2; P < 0.001). The average score for the fellows following conventional teaching was 7.9 out of 15 points on the checklist. Following the initial one-on-one hands-on demonstration the average score increased to 11.2 (difference = 3.3, 95% CI: 0.05 to 6.6; P = 0.047). During the retention of competence phase, scores ranged from 13-15 for both residents and fellows.Conclusion
This study describes a comprehensive teaching model for mastering the sterile technique during epidural catheter placement. It suggests that low-fidelity simulation improves the learning process when used in addition to conventional teaching. 相似文献96.
97.
Sarah Al-Beltagi Cristian Alexandru Preda Leah V. Goulding Joe James Juan Pu Paul Skinner Zhimin Jiang Belinda Lei Wang Jiayun Yang Ashley C. Banyard Kenneth H. Mellits Pavel Gershkovich Christopher J. Hayes Jonathan Nguyen-Van-Tam Ian H. Brown Jinhua Liu Kin-Chow Chang 《Viruses》2021,13(2)
The long-term control strategy of SARS-CoV-2 and other major respiratory viruses needs to include antivirals to treat acute infections, in addition to the judicious use of effective vaccines. Whilst COVID-19 vaccines are being rolled out for mass vaccination, the modest number of antivirals in use or development for any disease bears testament to the challenges of antiviral development. We recently showed that non-cytotoxic levels of thapsigargin (TG), an inhibitor of the sarcoplasmic/endoplasmic reticulum (ER) Ca2+ ATPase pump, induces a potent host innate immune antiviral response that blocks influenza A virus replication. Here we show that TG is also highly effective in blocking the replication of respiratory syncytial virus (RSV), common cold coronavirus OC43, SARS-CoV-2 and influenza A virus in immortalized or primary human cells. TG’s antiviral performance was significantly better than remdesivir and ribavirin in their respective inhibition of OC43 and RSV. Notably, TG was just as inhibitory to coronaviruses (OC43 and SARS-CoV-2) and influenza viruses (USSR H1N1 and pdm 2009 H1N1) in separate infections as in co-infections. Post-infection oral gavage of acid-stable TG protected mice against a lethal influenza virus challenge. Together with its ability to inhibit the different viruses before or during active infection, and with an antiviral duration of at least 48 h post-TG exposure, we propose that TG (or its derivatives) is a promising broad-spectrum inhibitor against SARS-CoV-2, OC43, RSV and influenza virus. 相似文献
98.
Michael Marks Pere Millat-Martinez Dan Ouchi Chrissy h Roberts Andrea Alemany Marc Corbacho-Monné Maria Ubals Aurelio Tobias Cristian Tebé Ester Ballana Quique Bassat Bàrbara Baro Martí Vall-Mayans Camila G-Beiras Nuria Prat Jordi Ara Bonaventura Clotet Oriol Mitjà 《The Lancet infectious diseases》2021,21(5):629-636
99.
Leandro Neckel Cristian A. Faller Matej Babi
Oscar R. K. Montedo Carlos P. Bergmann Rolf Janssen 《Materials》2021,14(1)
A study on the strength of ceramic fiber bundles based on experimental and computational procedures is presented. Tests were performed on single filaments and bundles composed of two fibers with different nominal fiber counts. A method based on fiber rupture signals was developed to estimate the amount of filament rupture during the test. Through this method, the fiber bundle true strength was determined and its variation with the initial fiber count observed. By using different load-sharing models and the single filament data as input parameter, simulations were also developed to verify this behavior. Through different approaches between experiments and simulations, it was noted that the fiber bundle true strength increased with the fiber count. Moreover, a variation of the fibers’ final proportion in the bundles relative to the initial amount was verified in both approaches. Finally, discussions on the influence of different load-sharing models on the results are presented. 相似文献
100.
José S. Merino Liliana Araneda Paulina Lincoñir-Campos Cristian Parra Katia Sáez Apolinaria García 《Enfermedades infecciosas y microbiología clínica》2019,37(2):109-111