Automated external defibrillators, life vest defibrillator, or both?

As most understand, survival of cardiac arrest victims falls significantly if cardioversion is not performed promptly. The standard of practice for out-of-hospital defibrillation is the implantable cardiac defibrillator; however, much has been written and discussed about the use of automated external defibrillators. Not as much has been written about life vest wearable defibrillators. How to use these devices will be reviewed in this article.     

In vitro bactericidal effect of Nd:YAG laser on Actinomyces israelii

A bactericidal effect has been reported by the use of near-infrared laser light on both Gram-positive and Gram-negative bacteria. The aim of this study was to evaluate the effect of Nd:YAG laser on Actinomyces israelii, filamentous bacteria causing cervicofacial actinomycosis. Experiments were realized on bacterial cells in saline suspension or streaked on Mueller–Hinton (MH) agar plates with or without India ink. Laser application was performed in Eppendorf tubes with different powers and frequencies for 40 s; bacterial suspensions were then streaked on agar plates and incubated at 35 °C in proper conditions for 5 days before colony enumeration. A reduction of colony number variable from 60.13 to 100 % for powers of 2, 4, and 6 W at 25–50 Hz of frequency was observed in comparison with growth control. For agar plates, laser application was performed with different powers at 50 Hz for 60 s. A growth inhibition was observed after 5 days of incubation on MH plates with powers of 6 W and on MH–ink plates with all applied powers. This preliminary study showed a bactericidal effect caused by Nd:YAG laser application worthy to be evaluated in further experiments in vivo.     

Non-invasive ventilation for severe TRALI and myocardial stunning: report and literature review

Transfusion-related acute lung injury (TRALI) is a frequently under-diagnosed, although potentially fatal, condition that represents a leading cause of transfusion-related morbidity and mortality even in pediatric patients. Its main clinical features are characterized by rapidly evolving respiratory distress, hypoxia, pulmonary edema, and bilateral infiltrates on chest radiograph during or within 6?h of transfusion. We present a case of severe TRALI associated with myocardial stunning that occurred in a 14-year-old girl, and review the existing literature of pediatric TRALI. Our report suggests a potential role for NIV in the management of TRALI as the best profile both in terms of safety and effectiveness for hematologic patients.     

Enhanced Bone Regeneration Using Porcine Small Intestinal Submucosa

Small instestinal submucosa (SIS) is an easily produced material that has been used experimentally for tissue engineering. To evaluate the ability of SIS to facilitate bone growth within a long-bone defect, a segment of the radius was surgically removed in adult, female Sprague-Dawley rats. The defect was either left unfilled or implanted with SIS, demineralized cortical bone (DMCB), or ovalbumin. The defect was evaluated radiographically and histologically after 3, 6, 12, and 24 weeks. Tissue remodeling within the defect was evident by week 3 in SIS- and DMCB-treated rats. Filling was characterized initially by infiltration of mononuclear cells and extracellular material in SIS-implanted rats and multifocal remodeling bone particles and cartilage formation in DMCB implanted rats. Cartilage was observed as early as 3 weeks and bone as early as 6 weeks in SIS-implanted rats. Filling of the defect arose from multiple foci in DMCB-implanted rats, but was contiguous with and parallel to the ulnar shaft in SIS-implanted rats, suggesting that defect repair by SIS may be conductive rather than inductive. Rats in which the defect was left unfilled demonstrated slow but progressive filling of the defect, characterized by mononuclear cell infiltrates and fibrous extracellular material. In summary, SIS facilitated rapid filling of a longbone defect. These results suggest that SIS may be useful as a bone repair material.     

Long-term follow-up of ruptured intracranial aneurysms treated by microsurgical wrapping with autologous muscle

The purpose of this study is to describe our series of nine unclippable and uncoilable ruptured aneurysms in eight patients treated by microsurgical wrapping with autologous muscle. Records were retrospectively reviewed for rebleeding rate, morbidity and mortality, changes in size or the aneurysm’s configurations, and inflammatory reaction. We conducted a Medline search in the post-microsurgical era, excluding patients in whom wrapping was part of the aneurysm treatment in combination with clipping or coiling. The surgically related morbidity was 12.5 %. Global mortality rate was 25 % due to vasospasm (one case) and rebleeding (one case). Six patients are still alive. Rebleeding rate was 14.3 % within 6 months; then, it was zero. Glasgow outcome scale (GOS) score at discharge was 1 and 4 in one patient, respectively, and 5 in the remaining six. Mean clinical follow-up was 126 months. GOS at last follow-up was 4 and 5 in 50 % of patients, respectively. Mean mRS score was 0.8 at 2 months, and 2.4 at 12 months. Follow-up MR demonstrated persistence of the aneurysm’s sac, without changes in size and configuration. Patients did not describe or exhibit symptoms attributable to complications inherent to the use of muscle. Microsurgical muscle-wrapping of ruptured intracranial aneurysm is safe, is associated with a low rate of acute and delayed postoperative complications and rebleeding, and could be a valid alternative for unclippable and non-amenable to endovascular procedure ruptured aneurysms.     

Metalloproteases and their inhibitors are altered in both torn and intact rotator cuff tendons

This article describes an anatomic, double-bundle, arthroscopic anterior cruciate ligament reconstruction technique with hamstrings using second-generation out-in retrograde femoral drills, second-generation cortical femoral suspensory fixation devices with adjustable graft loop length, standard out-in tibial drills, and titanium low-profile tibial staples. Grafts choice is autologous gracilis and semitendinosus tendons. They are harvested through the single minimally invasive tibial incision maintaining their tibial insertion. Sutures are tightened at the free proximal tendon ends to obtain a sufficient strength to traction. The grafts are reflected in two separate loops and linked to femoral adjustable TightRope graft loops. With this method, grafts length can be customized to the anatomy of every knee and their tension can be increased even after graft fixation. The preservation of tendons tibial insertion could improve the neoligamentization process, acting as a tenodesis.     

Comparison of root resorption between self-ligating and conventional preadjusted brackets using cone beam computed tomography

Objective:To compare the magnitude of external apical root resorption (EARR) of incisors in patients undergoing the initial phase of orthodontic treatment with two sets of brackets.Materials and Methods:According to the results of the power analysis for sample size calculation, 19 Angle Class I patients (anterior crowding: 3 to 5 mm; mean age: 20.6 years) were included in the study and randomly divided into two groups: group I (n  =  11, self-ligating brackets) and group II (n  =  8, conventional preadjusted brackets). The degree of EARR was detected in 152 upper and lower incisors by using cone-beam computed tomography (CBCT) scans and a three-dimensional program (Dolphin 11.5, Dolphin Imaging & Management Solutions, Chatsworth, Calif) with 25% level of sensitivity. The CBCT scans were obtained before (T1) and 6 months after initiation of treatment (T2). Differences between and within groups were analyzed by nonpaired and paired t-test, respectively, with 5% significance level.Results:Significant differences were found for both groups between T1 and T2. However, no differences in the degree of EARR were detected between the groups studied.Conclusions:Although EARR has occurred in all teeth evaluated, the bracket design (self-ligating or conventional) did not demonstrate any influence on the results observed.     

Estrazioni dentarie in regime ambulatoriale in pazienti in terapia con anticoagulanti orali

ObjectivesEvaluation of post-extraction bleeding in patients on oral anticoagulant (vitamin K antagonist) therapy.Materials and methodsWe reviewed 256 consecutive outpatient extractions performed between 4 July 2008 and 27 July 2010 on patients receiving oral anticoagulants (OAC). The INR during the 48 hours before the procedure was never above the therapeutic range (< 3.5). A total of 311 teeth were extracted.ResultsThere were no major hemorrhagic complications severe enough to require hospitalization, transfusion, and/or adjustment of OAC therapy. There were 4 cases of late bleeding that required a second outpatient visit; all were controlled with simple local measures (intra-alveolar oxidized cellulose, sutures and compression). The incidence of post-extraction bleeding was unrelated to the INR, and our results were not significantly different from those of other studies that used different protocols for post-extraction hemostasis. About a quarter of subjects had INRs below the therapeutic level.ConclusionsThis retrospective study confirms that vitamin K antagonists do not need to be stopped before dental extractions. Unfortunately, in many countries this approach is not always used in clinical practice.