全文获取类型
收费全文 | 5488篇 |
免费 | 291篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 161篇 |
妇产科学 | 132篇 |
基础医学 | 625篇 |
口腔科学 | 177篇 |
临床医学 | 489篇 |
内科学 | 1541篇 |
皮肤病学 | 105篇 |
神经病学 | 297篇 |
特种医学 | 309篇 |
外科学 | 630篇 |
综合类 | 157篇 |
预防医学 | 269篇 |
眼科学 | 29篇 |
药学 | 403篇 |
1篇 | |
中国医学 | 81篇 |
肿瘤学 | 370篇 |
出版年
2022年 | 40篇 |
2021年 | 98篇 |
2020年 | 56篇 |
2019年 | 67篇 |
2018年 | 90篇 |
2017年 | 84篇 |
2016年 | 72篇 |
2015年 | 100篇 |
2014年 | 123篇 |
2013年 | 146篇 |
2012年 | 240篇 |
2011年 | 243篇 |
2010年 | 188篇 |
2009年 | 158篇 |
2008年 | 230篇 |
2007年 | 224篇 |
2006年 | 205篇 |
2005年 | 195篇 |
2004年 | 201篇 |
2003年 | 198篇 |
2002年 | 172篇 |
2001年 | 160篇 |
2000年 | 139篇 |
1999年 | 149篇 |
1998年 | 107篇 |
1997年 | 103篇 |
1996年 | 96篇 |
1995年 | 87篇 |
1994年 | 91篇 |
1993年 | 69篇 |
1992年 | 107篇 |
1991年 | 94篇 |
1990年 | 95篇 |
1989年 | 105篇 |
1988年 | 90篇 |
1987年 | 78篇 |
1986年 | 102篇 |
1985年 | 69篇 |
1984年 | 57篇 |
1983年 | 56篇 |
1982年 | 38篇 |
1981年 | 40篇 |
1979年 | 48篇 |
1978年 | 41篇 |
1959年 | 35篇 |
1958年 | 59篇 |
1957年 | 87篇 |
1956年 | 45篇 |
1955年 | 75篇 |
1954年 | 67篇 |
排序方式: 共有5802条查询结果,搜索用时 937 毫秒
101.
Bolontrade MF; Stern MC; Binder RL; Zenklusen JC; Gimenez-Conti IB; Conti CJ 《Carcinogenesis》1998,19(12):2107-2113
In this study we have analyzed the vascular response induced in the two-
stage carcinogenesis model in SENCAR mice. The role of angiogenesis has not
been explored in this model, which is the paradigm of multistage
carcinogenesis and a model for neoplastic lesions derived from exophytic
premalignant lesions (e.g. colon carcinoma, bladder papilloma). We
investigated if angiogenesis is involved in the formation of papillomas and
in the progression from papilloma to carcinoma. To this end we analyzed the
vasculature of normal and hyperplastic skin, focal epidermal hyperplasias
that are precursors of papillomas, papillomas at different stages and
squamous cell carcinomas. We also analyzed the vascularization of
papillomas induced in two strains of mice that differ in their
susceptibility to malignant progression. We show here that angiogenesis is
turned on in the earliest stages of papilloma formation. In late stages,
regardless of state of progression, the predominant response is an increase
in the size of blood vessels. Thus, in the SENCAR mouse model,
representative of exophytic tumors, the angiogenesis switch is a very early
event, probably mechanistically related to the development of the primarily
exophytic lesions. Therefore, the density of blood vessels cannot be used
as a predictor of malignant progression in this model.
相似文献
102.
Non-invasive detection of fecal protein kinase C betaII and zeta messenger RNA: putative biomarkers for colon cancer 总被引:2,自引:0,他引:2
Davidson LA; Aymond CM; Jiang YH; Turner ND; Lupton JR; Chapkin RS 《Carcinogenesis》1998,19(2):253-257
We have developed a non-invasive method utilizing feces, containing
sloughed colonocytes, as a sensitive technique for detecting diagnostic
colonic biomarkers. In this study, we used the rat colon carcinogenesis
model to determine if changes in fecal protein kinase C (PKC) expression
have predictive value in monitoring the neoplastic process. Weanling rats
were injected with saline or azoxymethane (AOM) and 36 weeks later fecal
samples and mucosa were collected, poly A+ RNA isolated, and quantitative
RT-PCR performed using primers to PKC betaII and zeta. Fecal PKC betaII and
zeta mRNA levels were altered by the presence of a tumor, with
tumor-bearing animals having a 3-fold higher (P < 0.05) PKC betaII
expression as compared with animals without tumors. In addition,
AOM-injection increased mucosal PKC betaII mRNA expression compared with
saline controls. No effect of tumor incidence on mucosal PKC betaII
expression was observed. In contrast, fecal PKC zeta expression was
2.5-fold lower (P < 0.05) in animals injected with azoxymethane versus
saline. Since tumor incidence exerts a reciprocal effect on fecal PKC
betaII and zeta mRNA expression, data were also expressed as the ratio
between PKC betaII and zeta. The isozyme ratio was strongly related to
tumor incidence, i.e. ratio for animals with tumors was 2.18 +/- 1.25,
animals without tumors was 0.50 +/- 0.16, P = 0.025. We demonstrate that
the expression of fecal PKC betaII and zeta may serve as a noninvasive
marker for development of colon tumors. A sensitive technique for the
detection of colon cancer is of importance since early diagnosis can
substantially reduce mortality.
相似文献
103.
宫颈病变液基细胞学筛查与组织病理学对照观察 总被引:5,自引:1,他引:5
目的 探讨液基薄层细胞学(ThinPrepCytologyTest, TCT)技术在妇科门诊人群宫颈病变筛查的准确性。方法 回顾性分析10 980例TCT,与组织学对比观察。结果 TCTLSIL以上阳性率45. 7% ( 373 /817),组织学检查阳性率50. 1% ( 409 /817 ),两者统计学比较无显著性差异(P>0. 05 )。TCT诊断符合率LSIL75. 8% (191 /252),HSIL98. 1% (101 /103),SCC90. 9% (10 /11),AC85. 7% (6 /7)。鳞状上皮内病变诊断符合率HSIL与LSIL统计学比较有显著性差异(P<0. 01)。结论 液基细胞学检查是宫颈癌早期筛查的有效手段,加强制片技术及诊断质量控制对提高诊断的准确性有重要意义。 相似文献
104.
F Boccardo A Rubagotti M Battaglia P Di Tonno F P Selvaggi G Conti G Comeri A Bertaccini G Martorana P Galassi F Zattoni A Macchiarella A Siragusa G Muscas F Durand D Potenzoni A Manganelli V Ferraris F Montefiore 《Journal of clinical oncology》2005,23(4):808-815
PURPOSE: To determine whether tamoxifen or anastrozole prevents gynecomastia and breast pain caused by bicalutamide (150 mg) without compromising efficacy, safety, or sexual functioning. PATIENTS AND METHODS: A double-blind, placebo-controlled trial was performed in patients with localized, locally advanced, or biochemically recurrent prostate cancer. Patients (N = 114) were randomly assigned to either bicalutamide (150 mg/d) plus placebo or in combination with tamoxifen (20 mg/d) or anastrozole (1 mg/d) for 48 weeks. Gynecomastia, breast pain, prostate-specific antigen (PSA), sexual functioning, and serum levels of hormones were assessed. RESULTS: Gynecomastia developed in 73% of patients in the bicalutamide group, 10% of patients in the bicalutamide-tamoxifen group, and 51% of patients in the bicalutamide-anastrozole group (P < .001); breast pain developed in 39%, 6%, and 27% of patients, respectively (P = .006). Baseline PSA level decreased by > or = 50% in 97%, 97%, and 83% of patients in the bicalutamide, bicalutamide-tamoxifen, and bicalutamide-anastrozole groups, respectively (P = .07); and adverse events were reported in 37%, 35%, and 69% of patients, respectively (P = .004). There were no major differences among treatments in sexual functioning parameters from baseline to month 6. Elevated testosterone levels occurred in each group; however, free testosterone levels remained unchanged in the bicalutamide-tamoxifen group because of increased sex hormone-binding globulin levels. CONCLUSION: Anastrozole did not significantly reduce the incidence of bicalutamide-induced gynecomastia and breast pain. In contrast, tamoxifen was effective, without increasing adverse events, at least in the short-term follow-up. These data support the need for a larger study to determine any effect on mortality. 相似文献
105.
106.
107.
Real‐world medical costs of antiviral therapy among patients with chronic HCV infection and advanced hepatic fibrosis
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
108.
Coexistence of benign phyllodes tumor and invasive ductal carcinoma in distinct breasts: case report
Guerino Barbalaco Neto Claudia Rossetti Natalia A Souza Fernando LA Fonseca Ligia Ajaime Azzalis Virginia Berlanga Campos Junqueira Vitor E Valenti Luiz Carlos de Abreu 《European journal of medical research》2012,17(1):8
This report describes a rare case of coexistence of benign phyllodes tumor, which measured 9 cm in the right breast, and invasive ductal carcinoma of 6 cm in the left breast, synchronous and independent, in a 66-year-old patient. The patient underwent a bilateral mastectomy due to the size of both lesions. Such situations are rare and usually refer to the occurrence of ductal or lobular carcinoma in situ when associated with malignant phyllodes tumors, and more often in ipsilateral breast or intra-lesional. 相似文献
109.
110.