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11.
LY Chow MRCPsych D Chung MRCPsych V Leung MB BS TF Leung MB ChB CM Leung MRCPsych 《International journal of clinical practice》1997,51(5):330-331
Akathisia as a side-effect of metoclopramide has received increasing attention in consultation-liaison psychiatry in recent years. A case of metoclopramide-induced akathisia resulting in a suicide attempt is reported in order to highlight the suffering of such patients and the factors that lead to misdiagnosis. 相似文献
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Satoshi Hisano Winnie Chan Kay Latta Richard J Krieg Jr. James CM Chan 《Clinical and experimental nephrology》1997,1(3):179-186
Growth retardation is a major complication in children with uremia. Protein restriction, calorie deficit, metabolic acidosis,
renal osteodystrophy, and endocrinologic disturbances contribute to the growth failure. The effect of these factors on growth
retardation can be attenuated in part by therapy with vitamin D metabolites, adequate nutrition, alkalization, and dialysis.
Linear growth in children with uremia is markedly retarded despite normal or increased levels of circulating serum growth
hormone. An increased growth hormone level in children with uremia is due to normal growth hormone secretion from the pituitary
gland and impaired growth hormone clearance in the kidney. However, the elevated growth hormone level does not lead to a commensurate
rise in serum insulin-like growth factor I (IGF-I); the serum IGF-I level is decreased or normal in relation to the degree
of renal failure. This discrepancy suggests growth hormone resistance in the liver in uremia. Recent molecular techniques
open a new era in studying the gene expression for growth hormone or IGF-I. There is no doubt today that growth hormone treatment
has the beneficial effect of growth promotion in children with uremia, which also suggests endogenous growth hormone resistance
in target organs or target cells in uremia. 相似文献
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Caporale CM Capasso M Lucani M Gandolfi P De Angelis MV Di Muzio A Caporale V Uncini A . 《Journal of the peripheral nervous system : JPNS》2004,9(2):114-115
Campylobacter jejuni (C. jejunj) infection is the most common antecedent in the axonal variant of Guillain‐Barré syndrome (GBS). Antibodies against nerve gangliosides found in GBS patients recognize cross‐reactive epitopes in the lipopolysaccharide (LPS) of C. jejuni. This led to the molecular mimicry hypothesis of GBS. We immunized eleven rabbits with a LPS extracted from HS:19 C. jejuni strain isolated from a patient with GBS and complete Freund's adjuvant (CFA)(group I). In a second experiment we immunized seven rabbits with LPS, CFA and keyhole limpet hemocyanin (KLH)(group II). All group I rabbits developed high titers of anti‐LPS, anti‐GM1, anti‐GD1b antibodies and lower titers of anti‐GD1a. One rabbit, 50 days after initial inoculation, showed tremor and weakness. All rabbits of group II developed high titres of antiganglioside antibodies and six animals showed weakness 59–113 days after initial inoculation. Two rabbits died. Pathology showed mild to moderate, tendentially grouped, axonal degeneration in sciatic nerves of four out of five animals. Control rabbits of group I (immunized with CFA only) did not develop antibodies, controls of group II (immunized with CFA + KLH) developed low titers of IgG anti‐GM1. None developed neurological signs or showed axonal degeneration. C. jejuni LPS is a potent B‐cell stimulator capable to induce a strong antiganglioside response in rabbits. However, to induce the neuropathy is crucial to employ KLH, a glycoprotein known to stimulate both humoral and cellular responses. This animal model reproduces the pathogenetic process hypothesized in axonal GBS with antiganglioside antibodies post C. jejuni infection. 相似文献
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Continuous 4-channel EEG monitoring: a guide to interpretation, with normal values, in preterm infants 总被引:6,自引:0,他引:6
A system is described for the rapid analysis of the extensive EEG data produced by continuous 4-channel monitoring. Using this system, the initial EEGs of 44 low-risk preterm infants between 26 and 37 weeks gestation have been analysed and quantified in order to establish standard values. This provides a basis for assessment of the acute EEG as an index of cerebral function in high-risk or abnormal preterm infants. 相似文献
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A basic theory of nonspecific toxicity has been developed using bioconcentration as a basis and applying kinetic relationships developed in previous work. This approach has involved calculation of the critical volume fraction and critical concentration in lipid tissue of fish for a variety of organic compounds at the lethal level. Corrections to previous data sets for time period of exposure and inclusion of biodegradable compounds did not make a significant improvement in the values obtained. A new data base with compounds containing a wide range of Kow values gave results for critical volume and concentration similar to previous work. The influence of experimental procedures and methods for data development are considered. The basic theoretical derivation developed was found to provide a basis for predicting the approximate nonspecific toxicity of nondegradable lipophilic organic compounds at different exposure time periods. This requires a knowledge of the Kow value and the clearance rate constant (k2) which can be calculated from the Kow value. 相似文献
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R T Bissonnette D G Connell D G Fitzpatrick 《Journal l'Association canadienne des radiologistes》1988,39(4):286-287
A simple technique for the localization of foreign bodies using a spring hook wire under computed tomographic (CT) guidance is described. The advantages of CT in detecting foreign bodies of near water density and in planning a surgical approach which avoids important anatomical structures are emphasized. 相似文献