全文获取类型
收费全文 | 1814篇 |
免费 | 94篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 100篇 |
妇产科学 | 22篇 |
基础医学 | 162篇 |
口腔科学 | 28篇 |
临床医学 | 153篇 |
内科学 | 461篇 |
皮肤病学 | 11篇 |
神经病学 | 188篇 |
特种医学 | 71篇 |
外科学 | 338篇 |
综合类 | 7篇 |
预防医学 | 112篇 |
眼科学 | 17篇 |
药学 | 91篇 |
中国医学 | 2篇 |
肿瘤学 | 126篇 |
出版年
2023年 | 15篇 |
2022年 | 23篇 |
2021年 | 61篇 |
2020年 | 36篇 |
2019年 | 61篇 |
2018年 | 77篇 |
2017年 | 47篇 |
2016年 | 54篇 |
2015年 | 66篇 |
2014年 | 72篇 |
2013年 | 98篇 |
2012年 | 138篇 |
2011年 | 103篇 |
2010年 | 64篇 |
2009年 | 66篇 |
2008年 | 96篇 |
2007年 | 88篇 |
2006年 | 98篇 |
2005年 | 80篇 |
2004年 | 82篇 |
2003年 | 87篇 |
2002年 | 71篇 |
2001年 | 19篇 |
2000年 | 28篇 |
1999年 | 27篇 |
1998年 | 16篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 13篇 |
1994年 | 12篇 |
1993年 | 10篇 |
1992年 | 6篇 |
1991年 | 17篇 |
1990年 | 18篇 |
1989年 | 12篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1986年 | 11篇 |
1985年 | 12篇 |
1984年 | 10篇 |
1983年 | 7篇 |
1982年 | 13篇 |
1980年 | 5篇 |
1979年 | 7篇 |
1975年 | 5篇 |
1974年 | 4篇 |
1971年 | 5篇 |
1967年 | 5篇 |
1965年 | 4篇 |
1961年 | 4篇 |
排序方式: 共有1922条查询结果,搜索用时 15 毫秒
51.
ObjectiveOT was reported to be a direct regulator of bone mass in young rodents, and this anabolic effect on bone is a peripheral action of OT. The goal of this study was to investigate the peripheral action of oxytocin (OT) in the alveolar healing process in old female rats.Materials and methodsFemales Wistar rats (24-month-old) in permanent diestrus phase, received two ip (12 h apart) injections of saline (NaCl 0.15 M – control group) or OT (45 μg/rat – treated group). Seven days later, the right maxillary incisor was extracted and analyses were performed up to 28 days of the alveolar healing process (35 days after saline or OT administration).ResultsCalcium and phosphorus plasma concentrations did not differ between the groups. The plasma biochemical bone formations markers, alkaline phosphatase (ALP) and osteocalcin were significantly higher in the treated group. Histomorphometric analyses confirmed bone formation as the treated group presented the highest mean value of post-extraction bone formation. Tartrate-resistant acid phosphatase (TRAP) was significantly reduced in the treated group indicating an anti-resorptive effect of OT. Immunohistochemistry reactions performed in order to identify the presence of osteocalcin and TRAP in the bone cells of the dental socket confirmed these outcomes.ConclusionsOT was found to promote bone formation and to inhibit bone resorption in old acyclic female rats during the alveolar healing process. 相似文献
52.
Franca Franchi Eugenia Biguzzi Ida Martinelli Paolo Bucciarelli Claudia Palmucci Simona D’Agostino Flora Peyvandi 《Thrombosis research》2013
Introduction
Antithrombin (AT), protein C (PC) and protein S (PS) deficiencies are risk factors for venous thromboembolism. Overlapping values between heterozygous carriers and normal individuals often make a correct classification of a deficiency difficult. The aim of this study was to investigate the effect of sex, age, menopause and hormone therapy on natural anticoagulant plasma levels in a large group of healthy individuals, and to evaluate the need of separate reference ranges.Materials and Methods
AT and PC were measured with a chromogenic assay, antigenic free PS with an ELISA test. To evaluate the effect of sex, age, oral contraception, hormonal status (and their interaction) on AT, PC and PS levels, linear regression models were used. Biological relevance and the value of the normal deviate z were chosen as rules to decide for separate reference ranges.Results
The study population consisted of 1837 healthy adult individuals (741 men, 1096 women), aged 18-85 years (median age: 44 years). In men AT levels decreased after the age of 50 years. Men had higher levels of PS than women, particularly at young ages. In women, after correction for menopause, only PC levels increased with age. Menopause affected AT and PS, but not PC levels. Oral contraceptive intake was associated with a decrease of AT and PS, and an increase of PC levels.Conclusions
For AT, PC and PS, sex- and age-specific normal reference ranges can be useful, in order to better discriminate true carriers of a natural anticoagulant deficiency. 相似文献53.
54.
Huespe Pablo Ezequiel Oggero Sebastian de Santibañes Martín Boldrini Gustavo D´Agostino Daniel Pekolj Juan de Santibañes Eduardo Ciardullo Miguel Hyon Sung Ho 《Cardiovascular and interventional radiology》2019,42(3):466-470
CardioVascular and Interventional Radiology - Biliary complications after living donor liver transplantation (LDLT) cause severe morbidity and mortality, with biliary anastomotic stricture being... 相似文献
55.
56.
Hiromu Miyake Yong Chen Yuhki Koike Alison Hock Bo Li Carol Lee Augusto Zani Agostino Pierro 《Pediatric surgery international》2016,32(12):1153-1156
Purpose
Administration of hyperosmolar formula is regarded as a risk factor for the development of necrotizing enterocolitis (NEC). However, there are limited number of reports about the relationship between formula osmolality and NEC. The aim of this study is to evaluate the effects of formula concentration in an experimental model of NEC.Methods
We studied experimental NEC in C57BL/6 mice. NEC was induced by giving hypoxia, gavage administration of lipopolysaccharide and gavage formula feeding from postnatal day 5–9. We used two types of formula: (1) hyperosmolar formula (HF): 15 g Similac + 75 ml Esbilac (849 mOsm/kg); (2) diluted formula (DF): dilute hyperosmolar formula with an equal amount of water (325 mOsm/kg). Controls were fed by the mother. On postnatal day 9, the ileum was harvested and evaluated for severity of mucosal injury (hematoxylin/eosin staining) and inflammation (PCR for IL6 and TNFα mRNA expression).Results
The incidence of NEC was same in both HF and DF (80%). The intestinal inflammatory response was similar between HF and DF (IL6: p = 0.26, TNFα: p = 0.69).Conclusions
This study indicates the osmolality of enteral formula does not affect incidence of experimental NEC. This experimental study provides new insights into the relationship between formula feeding and NEC.57.
58.
Fabiola Paiar Agostino Cristaudo Alessandra Gonnelli Noemi Giannini Paola Cocuzza Sabrina Montrone Luca Bruschini Francesco Pasqualetti Stefano Ursino Pierluigi Bonomo 《Head & neck》2020,42(1):131-137
Radiation therapy is one of the cornerstones in the treatment of head and neck squamous cell carcinomas (HNSCC), alone or in combination with chemotherapy or surgery. Technological advances which occurred over the last few decades have increased the efficacy of radiotherapy (RT), particularly, intensity‐modulated RT (IMRT). IMRT can deliver treatments on complex tumoral targets with dose escalation while sparing organs at risk; anyway IMRT deposits dose in unpredictable patterns outside of the target volume with the purpose of improving conformality. Radiation‐induced nausea and vomiting (RINV) is a frequent albeit neglected side effect of RT that can lead to delays in treatment with serious consequences on cure rates. According to several guidelines (MASCC 2016, NCCN 2018), RT for HNSCC has traditionally been regarded as a low emetic risk treatment. Nevertheless, several works suggest that IMRT could increase RINV. Further studies are needed to define the exact incidence and the detailed pathophysiology of RINV in patients with HNSCC treated with state of art IMRT techniques, with and without concurrent chemotherapy. 相似文献
59.
Georgios Gakis Stephen A. Boorjian Alberto Briganti Steven Joniau Guram Karazanashvili R. Jeffrey Karnes Agostino Mattei Shahrokh F. Shariat Arnulf Stenzl Manfred Wirth Christian G. Stief 《European urology》2014
Context
Because pelvic lymph node (LN)-positive prostate cancer (PCa) is generally considered a regionally metastatic disease, surgery needs to be better defined.Objective
To review the impact of radical prostatectomy (RP) and pelvic lymph node dissection (PLND), possibly in conjunction with a multimodal approach using local radiotherapy and/or androgen-deprivation therapy (ADT), in LN-positive PCa.Evidence acquisition
A systematic Medline search for studies reporting on treatment regimens and outcomes in patients with LN-positive PCa undergoing RP between 1993 and 2012 was performed.Evidence synthesis
RP can improve progression-free and overall survival in LN-positive PCa, although there is a lack of high-level evidence. Therefore, the former practice of aborting surgery in the presence of positive nodes might no longer be supported by current evidence, especially in those patients with a limited LN tumor burden. Current data demonstrate that the lymphatic spread takes an ascending pathway from the pelvis to the retroperitoneum, in which the internal and the common iliac nodes represent critical landmarks in the metastatic distribution. Sophisticated imaging technologies are still under investigation to improve the prediction of LN-positive PCa. Nonetheless, extended PLND including the common iliac arteries should be offered to intermediate- and high-risk patients to improve nodal staging with a possible benefit in prostate-specific antigen progression-free survival by removing significant metastatic load. Adjuvant ADT has the potential to improve overall survival after RP; the therapeutic role of a trimodal approach with adjuvant local radiotherapy awaits further elucidation. Age is a critical parameter for survival because cancer-specific mortality exceeds overall mortality in younger patients (<60 yr) with high-risk PCa and should be an impetus to treat as thoroughly as possible.Conclusions
Increasing evidence suggests that RP and extended PLND improve survival in LN-positive PCa. Our understanding of surgery of the primary tumor in LN-positive PCa needs a conceptual change from a palliative option to the first step in a multimodal approach with a significant improvement of long-term survival and cure in selected patients. 相似文献60.
Sazzad Hassan Yelena Karpova Anabel Flores Ralph D’Agostino Jr. Suzanne C. Danhauer Ashok Hemal George Kulik 《International urology and nephrology》2014,46(3):505-510