全文获取类型
收费全文 | 686篇 |
免费 | 57篇 |
国内免费 | 60篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 43篇 |
妇产科学 | 8篇 |
基础医学 | 76篇 |
口腔科学 | 18篇 |
临床医学 | 105篇 |
内科学 | 227篇 |
皮肤病学 | 15篇 |
神经病学 | 16篇 |
特种医学 | 97篇 |
外科学 | 51篇 |
综合类 | 22篇 |
预防医学 | 38篇 |
眼科学 | 4篇 |
药学 | 44篇 |
中国医学 | 2篇 |
肿瘤学 | 35篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 10篇 |
2018年 | 20篇 |
2017年 | 10篇 |
2016年 | 15篇 |
2015年 | 19篇 |
2014年 | 28篇 |
2013年 | 33篇 |
2012年 | 20篇 |
2011年 | 23篇 |
2010年 | 28篇 |
2009年 | 30篇 |
2008年 | 31篇 |
2007年 | 55篇 |
2006年 | 23篇 |
2005年 | 20篇 |
2004年 | 12篇 |
2003年 | 14篇 |
2002年 | 17篇 |
2001年 | 16篇 |
2000年 | 8篇 |
1999年 | 18篇 |
1998年 | 35篇 |
1997年 | 37篇 |
1996年 | 23篇 |
1995年 | 23篇 |
1994年 | 29篇 |
1993年 | 20篇 |
1992年 | 5篇 |
1991年 | 11篇 |
1990年 | 4篇 |
1989年 | 19篇 |
1988年 | 21篇 |
1987年 | 15篇 |
1986年 | 4篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 10篇 |
1981年 | 12篇 |
1980年 | 8篇 |
1978年 | 7篇 |
1977年 | 8篇 |
1976年 | 10篇 |
1975年 | 4篇 |
1966年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有803条查询结果,搜索用时 62 毫秒
61.
Background The National Health Strategy envisages a health system incorporating patient views; and providing accessible, consultant-led
dialysis services with patient choice of dialysis modality, in all regions.
Aims To describe patients’ experiences of renal services against National Health Strategy objectives.
Methods Telephone interviews with 192 dialysis patients from three hospitals in the Eastern region.
Results One-quarter of participants (16% of haemodialysis [HD] and 46% of peritoneal dialysis patients) lived outside the Eastern
region, and travelled there because dialysis was not available locally. Two-thirds (65%) had a choice of dialysis modality.
High satisfaction with interpersonal care was observed (83–98% satisfaction). Dissatisfaction with physical environment included
parking (39–56%), waiting areas (62–69%), HD unit space (74%). Regarding support services, dietary services were satisfactory
(92–95%), with lower satisfaction ratings for social and financial support services (62%).
Conclusions Structural and management issues must be addressed to advance a quality agenda for renal care in Ireland. 相似文献
62.
Annette?AM?GerritsenEmail author Inge?Bramsen Walter?Devillé Loes?HM?van Willigen Johannes?E?Hovens Henk?M?van der Ploeg 《BMC public health》2004,4(1):7
Background
This article discusses the design of a study on the prevalence of health problems (both physical and mental) and the utilisation of health care services among asylum seekers and refugees in the Netherlands, including factors that may be related to their health and their utilisation of these services. 相似文献63.
OBJECTIVE: In 196 type 1 diabetic subjects and 195 nondiabetic subjects aged 30-55 years, we examined whether C-reactive protein (CRP) is elevated in diabetes and whether CRP is associated with coronary artery calcification (CAC). RESEARCH DESIGN AND METHODS: CRP was measured with a highly sensitive immunoassay. CAC was measured using electron beam computed tomography. RESULTS: CRP was elevated in diabetic women compared with nondiabetic women (median 1.62 vs. 0.85 mg/l, P < 0.001) independently of other factors, but was similar in diabetic and nondiabetic men (median 0.82 vs. 0.81 mg/l). Insulin dose per day was positively correlated with CRP in diabetic women (Spearman's rho = 0.36, P = 0.0003) but much less so in men (rho = 0.16, P = 0.09). Being in the top tertile for CRP was associated with CAC in diabetic and nondiabetic men even after adjustment for other risk factors (adjusted odds ratio [OR] = 4.6 and 4.3, respectively, P = 0.02 for both). In nondiabetic women, being in the top tertile for CRP was associated with CAC (OR 3.1, P = 0.04), but not independently of BMI (OR = 1 after adjustment). Among diabetic women the association was not significant even before adjustment for BMI (OR = 2.6, P = 0.07). CONCLUSIONS: Elevated CRP in diabetic women might reflect a particular sensitivity to insulin levels or might reflect insulin resistance. In general, CRP is an important marker of subclinical atherosclerosis, but the clinical significance of elevated CRP in diabetic women needs to be addressed in prospective studies, since CRP was not clearly associated with CAC in this group. 相似文献
64.
Background Baroreflex sensitivity (BRS) and heart rate variability (HRV) are attenuated in cardiovascular disease and can give important prognostic information. Conventional measures of BRS require expensive or invasive equipment for the beat-to-beat measure of blood pressure (BP). We examined the possibility of developing a simple protocol that would provide a relatively standardized BP stimulus, which might obviate the need to measure BP beat-by-beat. Methods and Results Fifty-five patients with chronic heart failure (mean age 59 [SD 11] years) and 20 healthy control subjects (mean age 53 [SD 14] years, P not significant) underwent 5-minute recordings of BP (by photoplethysmograph) and R-R interval during 0.1-Hz controlled breathing. The size of the oscillations in BP was the same in the 2 groups (3.6 mm Hg vs 4.1 mm Hg, P = .5). There was, however, a significant difference in the amplitude of the R-R interval oscillations (77 ms vs 31 ms, P < .0001). The amplitude of the R-R interval oscillations correlated strongly with BRS (r = 0.81, P < .0001 with controlled breathing BRS, and r = 0.51, P < .0001 with α index). There was no correlation with the size of BP oscillations (r = −0.13, P not significant with controlled breathing BRS, and r = −0.15, P not significant with α index). In a separate study, a group of 22 young patients (mean age 36 years) with type I diabetes mellitus and 28 healthy control subjects (mean age 39 years) underwent measurement of resting HRV and amplitude of R-R interval oscillations during 0.1-Hz breathing. There was no significant difference in triangular index or low-frequency R-R interval power between the 2 groups. There was, however, a significant difference in the amplitude of R-R interval oscillations during controlled breathing between patients with diabetes and healthy control subjects. Total and high-frequency RR interval variability was also significantly different between the 2 groups. Conclusion During 0.1-Hz breathing, the marked difference in BRS between patients with CHF and age-matched control subjects is the result of smaller R-R interval oscillations. In young patients with diabetes, these R-R interval oscillations are significantly smaller than age-matched control subjects, even when some measures of spontaneous HRV are not different between groups. Breathing at 0.1 Hz provides a standard BP stimulus and concentrates spectral power of heart rate at one frequency, enabling simple evaluation of BRS even when BP measurement is not available. (Am Heart J 2002;143:441-7.) 相似文献
65.
Soedamah-Muthu SS Colhoun HM Abrahamian H Chan NN Mangili R Reboldi GP Fuller JH;EURODIAB Prospective Complications Study Group 《Diabetologia》2002,45(10):1362-1371
Aims/hypothesis
Our aim was to examine the change in the management of hypertension in patients with Type I (insulin-dependent) diabetes mellitus in Europe, between 1989–1990 and 1997–1999.Methods
Seven-year changes in hypertension treatment and control (defined as blood pressure <130/85 mmHg) were examined in a large sample of Type I diabetic patients recruited from 26 centres involved in the EURODIAB Prospective Complications Study. Hypertension was defined as a systolic and/or diastolic blood pressure greater than 140 and/or 90 mmHg respectively, and/or use of blood pressure lowering drugs.Results
Of 1866 Type I diabetic patients, 412 had hypertension at baseline and 631 at follow-up. A greater proportion of hypertensive patients were treated at follow-up (69% vs 40%, p<0.0001), which persisted after adjustment for age or centre. Of those who were treated, a modest increase in the proportion of those controlled for hypertension was found (41% vs 32%, p=0.048), which disappeared after adjustment for age. Among hypertensive patients with albuminuria, the proportions treated also increased, from 35% to 76% (p<0.0001) in microalbuminuric and 64% to 95% (p<0.0001) in macroalbuminuric patients. Control of hypertension in albuminuric patients did not change significantly and was below 50%. The use of more than one anti-hypertensive drug increased over a 7-year period, from 19% to 33% (p<0.0001), and a marked increase was shown in the proportion of those taking an ACE inhibitor (from 57% to 82%, p<0.0001).Conclusion/interpretation
The management of hypertension in Type I diabetic patients across Europe has improved over a 7-year follow-up period. Optimal levels of blood pressure treatment and optimal levels of control have not yet been achieved.Abbreviations CCB Calcium channel blockerAn erratum to this article can be found at 相似文献
66.
67.
M P Willmott E M Colhoun A E Bolton 《Acta obstetricia et gynecologica Scandinavica》1977,56(2):145-149
The therapeutic value of 2-Br-alpha-ergocryptine for the suppression of puerperal lactation was studied in 30 normal women; 16 received the drug, 14 were controls. In six women plasma levels of FSH, oestradiol and alpha-lactalbulmin were measured in labour and in the early puerperium. Brom-ergocryptine was found effectively to suppress milk production and alleviate breast pain and congestion, with no side effects and minimum rebound lactation. The inverse relationship between prolactin and FSH levels reported elsewhere in non-pregnant women did not appear to occur in the early postpartum period. Although there was a significant rise in alpha-lactalbumin levels in labour and the puerperium over non-pregnant levels, there was no difference between lactating and non-lactating women. 相似文献
68.
1 病例报告 男,7岁.因双下肢不等长,右膝及右踝关节骨性肿大就诊.无明显外伤史,亦无红、肿、热、痛病史.查体:发育正常,营养良好.双下肢不等长,左60cm,右64cm,有跛行.右膝及右踝内侧肿大,肤色正常,关节活动无异常.X线:右侧半身诸关节(肩、肘、腕、髋、膝、踝)骨骺及干骺发育均较左侧增大,肢体较长,骨骺出现亦较对侧提早.如右尺骨茎突骨骺较左侧提早出现(图1).右肘关节肱骨小头骨骺较左侧增大(图2).右髋臼发育浅平,边缘毛糙,右股骨头骨骺较左侧明显增大,其距泪滴之距离较左侧大1.0cm,呈… 相似文献
69.
70.