Einfluß der Ultraviolettbestrahlung auf die Malignitätsdisposition des Kaninchenkrebses

Zusammenfassung Faßt man die Ergebnisse beider oben geschilderten Versuche zusammen, so kommt man zu dem Schluß, daß durch UV.-Bestrahlung in einigermaßen vernünftiger Dosierung die Malignitätsdisposition des Kaninchensnicht gesteigert wird. Selbst wenn man zugibt, daß durch extremste Überdosierung unter Umständen Neoplasmen entstehen können, so zeigen doch die eigenen Versuche die Unschädlichkeit einer mäßigen Strahlendosierung. Wir glauben, diese beim Kaninchen gewonnenen Ergebnisse auch auf den Menschen übertragen zu dürfen: Die von einigen Autoren festgestellte Möglichkeit eines Höhensonnen-krebses ist für die Praxisohne jede Bedeutung.Weiterhin aber geht aus den geschilderten Versuchen hervor, daß durch UV.-Bestrahlung allein oder in Kombination mit Eisentherapie die Malignitätsdisposition des Kaninchens in keiner Weise verringert wird.Sieht man von der unter besonderen Versuchsbedingungen geglücktenErzeugung maligner Tumoren durch extreme Bestrahlung ab, kommt man zu dem Schluß:Ultraviolette Strahlen und Carcinomwachstum haben miteinander nichts zu tun.     

Zeitschriften

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Einzelreferate und Buchbesprechungen

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Die Symptomatologie der Poliomyelitis Acuta

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Chemie und Pharmakologie des Targesin

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A MODIFICATION OF VAN LEERSUM'S BLOODLESS METHOD FOR RECORDING BLOOD PRESSURES IN ANIMALS

It has been shown that enzymes in serum will change maltose, dextrin, and starch so that they will react as dextrose in media. These enzymes are destroyed by heating to 60°C. for 15 minutes, but they are present in sera that have been refrigerated for as long as 18 months. The practice of using carbohydrate media containing unheated serum should be discouraged, and if it is used the possibility that the carbohydrate may be changed by the enzymes present must be considered.     

Einzelreferate und Buchbesprechungen

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THE ACTION OF DIGITALIS IN PNEUMONIA

We have shown in a series of 105 cases of pneumonia, 95 of which we have selected as available for statistical study, that digitalis given by mouth has an action on the heart. We have judged this action to be present because changes occurred in the auriculoventricular conduction time and in the form of the T wave of the electrocardiogram, just as they do in the non-febrile heart. This conclusion is strengthened by finding that the pulse rate in fibrillating and fluttering cases fell in the presence of fever, exactly as it does in non-febrile cases. The dose and the time required to produce these effects are given and are the same as in the non-febrile cases. When there was a difference in the amount necessary to produce one or the other of the changes, it was found that the T wave is more often and more readily affected than the conduction interval. We have shown that the intoxication due to pneumonia is probably not responsible for the changes found, both from a study of the statistics and because in the control cases reverse tendencies were often found (that is, decrease in conduction time and increase in the size of the T wave). We have shown that the method of selection in consequence of which we treated a large number of severe cases did not prejudice our results, because it could be demonstrated that the proximity of death, whether in control or treated cases, was not necessarily associated with the changes we are describing. We have also, by referring to the literature of the subject, brought evidence to show that heart muscle does not undergo those changes in pneumonia, as it does in other infectious diseases, which would lead one to expect changes in conduction found in other diseases. The changes in conduction which have been reported by others were almost entirely associated with the giving of digitalis.     

Ueber den Keimgehalt der Frauenmilch

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Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation

BACKGROUND: Near-infrared spectroscopy (NIRS) can continuously and noninvasively monitor tissue oxygen saturation (StO2) in muscle and may be an indicator of shock severity. Our purpose was to evaluate how well StO2 predicted outcome in high-risk torso trauma patients presenting in shock. METHODS: The primary outcome in this prospective study was multiple organ dysfunction syndrome (MODS). StO2 data were obtained upon hospital arrival and for 24 hours along with other known predictors of hypoperfusion and clinical outcomes. Clinicians were blinded to StO2 measurements. RESULTS: Seven Level I trauma centers enrolled 383 patients, 50 of whom developed MODS. Minimum StO2 performed similarly to maximum base deficit (BD) in discrimination of MODS patients. The sensitivity for both measures (StO2 cutoff = 75%; BD cutoff = 6 mEq/L) was 78%, the specificity was 34% to 39%, the positive predictive value was 18% to 20% and the negative predictive value was 88% to 91%. StO2 and BD were also comparable in predicting death. CONCLUSIONS: NIRS-derived muscle StO2 measurements perform similarly to BD in identifying poor perfusion and predicting the development of MODS or death after severe torso trauma, yet have the additional advantages of being continuous and noninvasive.