全文获取类型
收费全文 | 586篇 |
免费 | 40篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 71篇 |
妇产科学 | 7篇 |
基础医学 | 69篇 |
口腔科学 | 11篇 |
临床医学 | 80篇 |
内科学 | 128篇 |
皮肤病学 | 18篇 |
神经病学 | 33篇 |
特种医学 | 94篇 |
外科学 | 34篇 |
综合类 | 11篇 |
预防医学 | 21篇 |
眼科学 | 1篇 |
药学 | 28篇 |
中国医学 | 1篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2020年 | 4篇 |
2019年 | 6篇 |
2018年 | 9篇 |
2017年 | 14篇 |
2016年 | 9篇 |
2015年 | 17篇 |
2014年 | 13篇 |
2013年 | 31篇 |
2012年 | 14篇 |
2011年 | 15篇 |
2010年 | 34篇 |
2009年 | 23篇 |
2008年 | 15篇 |
2007年 | 10篇 |
2006年 | 12篇 |
2005年 | 11篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 9篇 |
2001年 | 10篇 |
2000年 | 4篇 |
1999年 | 10篇 |
1998年 | 22篇 |
1997年 | 31篇 |
1996年 | 27篇 |
1995年 | 32篇 |
1994年 | 23篇 |
1993年 | 37篇 |
1992年 | 5篇 |
1991年 | 7篇 |
1990年 | 15篇 |
1989年 | 17篇 |
1988年 | 17篇 |
1987年 | 11篇 |
1986年 | 13篇 |
1985年 | 14篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 6篇 |
1981年 | 14篇 |
1980年 | 6篇 |
1979年 | 2篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1976年 | 12篇 |
1975年 | 4篇 |
1966年 | 1篇 |
1957年 | 1篇 |
排序方式: 共有627条查询结果,搜索用时 0 毫秒
71.
Cytogenetic and molecular delineation of a region of chromosome 7 commonly deleted in malignant myeloid diseases 总被引:8,自引:2,他引:8
Loss of a whole chromosome 7 or a deletion of the long arm, del(7q), are recurring abnormalities in malignant myeloid diseases. To determine the location of genes on 7q that are likely to play a role in leukemogenesis, we examined the deleted chromosome 7 homologs in a series of 81 patients with therapy-related or de novo myelodysplastic syndrome or acute myeloid leukemia. Our analysis showed that the deletions were interstitial and that there were two distinct deleted segments of 7q. The majority of patients (65 of 81 [80%]) had proximal breakpoints in bands q11-22 and distal breakpoints in q31-36; the smallest overlapping deleted segment was within q22. The remaining 16 patients had deletions involving the distal q arm with a commonly deleted segment of q32-33. To define the proximal deleted segment at 7q22 at a molecular level, we used fluorescence in situ hybridization with a panel of mapped yeast artificial chromosome (YAC) clones from 7q to examine 15 patients with deletion breakpoints in 7q22. We determined that the smallest overlapping deleted segment is contained in a well- defined YAC contig that spans 2 to 3 Mb. These studies delineate the region of 7q that must be searched to isolate a putative myeloid leukemia suppressor gene, and provide the necessary cloned DNA for more detailed physical mapping and gene isolation. 相似文献
72.
Marjolein EM den Ouden Marieke J Schuurmans Ilse EMA Arts Yvonne T van der Schouw 《Geriatrics & Gerontology International》2013,13(2):274-280
Aim: Functional status at one moment in time is a determinant of future functional status and survival. Physical deterioration tends to occur early in the disabling process; however, etiological questions remain. This study investigated the association between physical performance characteristics and functioning independently in middle‐aged and elderly men. Methods: A total of 400 independently‐living men aged 40–80 years were included in this cross‐sectional study. Preservation of function was measured using the Stanford Health Assessment Questionnaire. Physical characteristics were muscle strength and power by dynamometer, lung function, lower extremity function by physical performance score, and physical activity by Voorrips‐questionnaire. Logistic regression analysis was used to estimate the association between potential determinants and the dichotomized Health Assessment Questionnaire score. The odds ratios (OR) were adjusted for age, body mass index, education, socioeconomic status, smoking, alcohol and number of chronic diseases. Results: After adjustment for confounders, higher walking speed (OR = 2.96, 95% CI 1.31–6.72) and shorter time to carry out the chair stand test (OR = 0.84, 95% CI 0.76–0.94) were associated with a higher probability of being independent in activities of daily living (ADL). Borderline significant associations were found for higher lung function and higher leg strength with higher probability of being independent in ADL. No associations were found for grip strength, physical performance score, standing balance and physical activity. Conclusion: Lower body function and lung function were associated with a higher probability of being independent in ADL. Geriatr Gerontol Int 2013; 13: 274–280 . 相似文献
73.
74.
75.
76.
77.
Hartdorff Caroline M Frank Kneepkens CM van Dijk Alice EM Stok Anita Engels Michelle AH Gemke Reinoud JBJ Kindermann Angelika 《Tijdschrift voor kindergeneeskunde》2013,81(1):11-11
Tijdschrift voor Kindergeneeskunde - 相似文献
78.
Enio R Vasques Estela RR Figueira Joel A Rocha-Filho Cinthia Lanchotte Jorge LS Ximenes Helena B Nader Ivarne LS Tersariol Marcelo A Lima Tiago Rodrigues José EM Cunha Eleazar Chaib Luiz AC D'Albuquerque Flávio HF Galv?o 《Hepatobiliary & pancreatic diseases international : HBPD INT》2022,21(2):190-192
<正>To the Editor:Ischemia-reperfusion injury following surgery and transplantation can lead to irreversible multiorgan failure.Intracellular calcium overload is associated to cellular death during ischemiareperfusion.A recently discovered heparin fragment (HF),trisulfated disaccharide (TD),that acts on sodium-calcium exchanger(NCX) decreasing intracellular Ca2+,showed effectiveness on protecting hepatocytes from ischemia-reperfusion injury [1], 相似文献
79.
Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura 总被引:11,自引:0,他引:11
Bussel JB; Kimberly RP; Inman RD; Schulman I; Cunningham-Rundles C; Cheung N; Smithwick EM; O'Malley J; Barandun S; Hilgartner MW 《Blood》1983,62(2):480-486
High-dose intravenous gammaglobulin (IVIgG) was given to 12 children and adults with chronic idiopathic thrombocytopenic purpura (ITP) to avoid splenectomy or because they either failed to respond to or required maintenance with high doses of steroids and/or immunosuppressives. The average platelet count increase to initial therapy was 239,500/microliters (range 23,000-790,000). A concomitant IgG Fc receptor blockade, measured by IgG-sensitized 51Cr-labeled autologous erythrocytes, was seen in 11 of 11 patients tested, both splenectomized and not splenectomized, lasting 3-4 wk. Six or more months after treatment, 2 children are in remission, 2 children and 2 adults are stable requiring no therapy with platelet counts of approximately 50,000 and 30,000, respectively, 3 children require maintenance IVIgG therapy at 2-10-wk intervals, and 1 child and 2 adults have become refractory to further IVIgG. Splenectomy was not performed in 4 children. Two adults were able to discontinue daily prednisone. The 3 patients who became unresponsive to Swiss Red Cross gamma-globulin (IgSRK) therapy did so in conjunction with a markedly elevated platelet-associated IgG and IgM. Serum IgM increased an average of 103 mg/dl after the IVIgG infusions. No significant side effects were seen. 相似文献
80.
DS Keller RN Tahilramani JR Flores-Gonzalez S. Ibarra EM Haas 《Surgical endoscopy》2016,30(6):2192-2198