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61.
氯地滴眼液的含量测定 总被引:4,自引:0,他引:4
目的:采用HPLC法测定氯地滴眼液中氯霉素和地塞米松磷酸钠的含量。方法:色谱分析条件:ODS柱作分析柱,流动相为甲醇/水体系,0 ̄8min使用40%甲醇,8 ̄16min使用60%甲醇,流速1ml/min,0 ̄9min240nm紫外检测,:二组分分离良好。各组各组性关系良好,平均回收率氯霉素99.8%(RSD=1.2%,n=5),地塞米松磷酸钠99.4%(RSD=0.7%,n=5),结论:该法用于氯 相似文献
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How do aquatic communities respond to contaminants? It depends on the ecological context 总被引:1,自引:0,他引:1
Context dependency refers to variation in ecological patterns and processes across environmental or spatiotemporal gradients. Research on context dependency in basic ecology has focused primarily on variation in the relative importance of species interactions (e.g., competition and predation) among communities. In this Focus article, the authors extend this concept to include variation in responses of communities to contaminants and other anthropogenic stressors. Because the structure of communities varies naturally along environmental gradients, their responses to contaminants may also vary. Similar to the way in which aquatic toxicologists assess abiotic factors associated with contaminant bioavailability, observations about context dependency could be used to test hypotheses about ecological mechanisms responsible for differences in sensitivity among communities. Environ. Toxicol. Chem. 2012; 31: 1932-1940. ? 2012 SETAC. 相似文献
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B F Stanton J D Clemens J D Clements 《Transactions of the Royal Society of Tropical Medicine and Hygiene》1986,80(3):485-488
We examined the relationship between uses of the sari that are potential health hazards and episodes of diarrhoea in children younger than 6 years in 247 families living in 51 slums in Dhaka, Bangladesh. These misuses appeared to be common (median of three per observation period) and were largely unrecognized by the women as possible sources of disease transmission. There appeared to be a positive correlation between the number of misuses of the sari and episodes of childhood diarrhoea. 相似文献
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Michael Weed Robert J. Adams Robert D. Hienz Kelly A. Meulendyke Michael E. Linde Janice E. Clements Joseph L. Mankowski M. Christine Zink 《Journal of neuroimmune pharmacology》2012,7(2):401-411
Studies of the effects of drugs of abuse on HIV immune status, disease progression, and neuroAIDS have produced conflicting data and have not definitively shown whether this combination promotes cognitive impairment or disease progression. Using a consistent SIV?Cmacaque model, we investigated the effects of cocaine on behavior, virologic parameters, and CNS inflammation. Macaques received either vehicle or chronic administration of behaviorally active doses of cocaine (1.7 or 3.2?mg/kg/day). Chronic cocaine administration reduced CD8+ T cell counts during acute and late stage infection but had no effect on CD4+ T cell counts. Low-dose cocaine-treated animals had lower CSF vRNA levels late in infection, but cocaine did not alter plasma viral load or vRNA or protein in brain. There were no differences in CSF CCL-2 or interleukin (IL)-6 levels or severity of encephalitis in cocaine-treated as compared to vehicle-treated macaques. There were no differences in brain inflammation or neurodegeneration markers, as determined by interferon (IFN)-??, MxA, CCL2, IL-6, TNF??, IFN??, and indolamine 2,3-deoxygenase mRNA levels. APP levels also were not altered. The executive function of inhibitory control was not impaired in cocaine-treated or control animals following SIV infection. However, animals receiving 3.2?mg/kg/day cocaine performed more slowly in a bimanual motor test. Thus, chronic administration of cocaine produced only minor changes in behavior, encephalitis severity, CNS inflammation/neurodegeneration, and virus replication in SIV-infected pigtailed macaques, suggesting that cocaine would have only modest effects on the progression of neuroAIDS in HIV-infected individuals. 相似文献
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