全文获取类型
收费全文 | 1949篇 |
免费 | 146篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 60篇 |
妇产科学 | 34篇 |
基础医学 | 228篇 |
口腔科学 | 91篇 |
临床医学 | 143篇 |
内科学 | 396篇 |
皮肤病学 | 213篇 |
神经病学 | 119篇 |
特种医学 | 67篇 |
外科学 | 237篇 |
综合类 | 10篇 |
预防医学 | 191篇 |
眼科学 | 16篇 |
药学 | 122篇 |
中国医学 | 8篇 |
肿瘤学 | 113篇 |
出版年
2023年 | 12篇 |
2022年 | 22篇 |
2021年 | 57篇 |
2020年 | 29篇 |
2019年 | 46篇 |
2018年 | 76篇 |
2017年 | 50篇 |
2016年 | 62篇 |
2015年 | 72篇 |
2014年 | 78篇 |
2013年 | 70篇 |
2012年 | 113篇 |
2011年 | 121篇 |
2010年 | 70篇 |
2009年 | 56篇 |
2008年 | 112篇 |
2007年 | 108篇 |
2006年 | 116篇 |
2005年 | 117篇 |
2004年 | 101篇 |
2003年 | 91篇 |
2002年 | 80篇 |
2001年 | 66篇 |
2000年 | 66篇 |
1999年 | 55篇 |
1998年 | 14篇 |
1997年 | 12篇 |
1996年 | 9篇 |
1995年 | 15篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 26篇 |
1991年 | 18篇 |
1990年 | 14篇 |
1989年 | 18篇 |
1988年 | 18篇 |
1987年 | 8篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 5篇 |
1983年 | 8篇 |
1982年 | 5篇 |
1981年 | 4篇 |
1979年 | 11篇 |
1977年 | 5篇 |
1975年 | 4篇 |
1974年 | 4篇 |
1972年 | 4篇 |
1971年 | 4篇 |
1968年 | 4篇 |
排序方式: 共有2102条查询结果,搜索用时 15 毫秒
91.
92.
93.
Martínez-Piñeiro JA Flores N Isorna S Solsona E Sebastián JL Pertusa C Rioja LA Martínez-Piñeiro L Vela R Camacho JE Nogueira JL Pereira I Resel L Muntañola P Galvis F Chesa N De Torres JA Carballido J Bernuy C Arribas S Madero R;for CUETO 《BJU international》2002,89(7):671-680
OBJECTIVES: To determine the efficacy of a three-fold reduced dose (RD, 27 mg) of intravesical bacille Calmette-Guérin (BCG) against the standard dose (81 mg) in patients with superficial bladder cancer, assessing recurrence, progression and differences in toxicity. PATIENTS AND METHODS: Five hundred patients with superficial bladder cancer (Ta, T1, Tis) were enrolled and randomly assigned to be treated after transurethral resection of all visible lesions with intravesical BCG Connaught strain (weekly x six and thereafter fortnightly x six) either with the standard or RD instillation. RESULTS: All but one of the 500 patients were evaluable for efficacy and toxicity (252 in the standard arm and 247 in the RD arm). The median follow-up was 69 months (maximum 104); 71 (28%) patients in the standard arm and 76 (31%) in the RD arm developed recurrences; the median time to recurrence has not yet been attained, but at 5 years the mean (sd) percentage of recurrence-free patients was 70.5 (3.12) and 70.4 (3.1) for the standard and RD arms, respectively. In patients presenting with multifocal tumours, the standard dose was more effective against recurrences than the RD (P=0.0151). In those with G3 and high-risk tumours overall, the superiority of the standard dose was marginal (P=0.060 and P=0.082). Twenty-nine (11.5%) tumours in the standard arm and 33 (13.3%) in the RD arm progressed to invasive disease; the median time to progression has not yet been attained, but the percentage of progression-free patients at 5 years was 88.8 (2.23) and 86.9 (2.31) for the standard and RD arms, respectively. The standard dose was more effective than the RD against progression only in patients with multifocal disease (P=0.048). Twelve (4.8%) cystectomies were performed in the standard and 15 (6.1%) in the RD arm. Currently, 106 (21.2%) patients have died, but only 38 (7.6%) from bladder cancer, i.e. 20 (7.9%) in the standard and 18 (7.5%) in RD arm. Overall the disease-specific death rate was lower for those patients who completed the scheduled treatment. The cause-specific survival at 5 years did not differ between the arms (P=0.76) but there was a trend toward better cause-specific survival for patients with multifocal tumours in the standard arm. Toxicity differed between the arms, significantly more patients having no toxicity in the RD arm, and fewer having delayed instillations or withdrawing. However, severe systemic toxicity occurred even in patients treated with the RD, in a similar proportion to those receiving the standard dose. CONCLUSION: Overall, the RD gave similar results for recurrence and progression but with significantly less toxicity. However, patients with multifocal tumours fared better with the standard dose and there was a trend towards better recurrence rates in patients with high-risk tumours. We recommend continuing to use the standard dose for high-risk tumours, while we consider the reduced dose safe and effective for intermediate-risk lesions and for maintenance schedules. 相似文献
94.
Yolanda Ruano Manuela Mollejo Teresa Ribalta Concepción Fiaño Francisca I Camacho Elena Gómez Angel Rodríguez de Lope Jose-Luis Hernández-Moneo Pedro Martínez Bárbara Meléndez 《Molecular cancer》2006,5(1):39-12
Background
Conventional cytogenetic and comparative genomic hybridization (CGH) studies in brain malignancies have shown that glioblastoma multiforme (GBM) is characterized by complex structural and numerical alterations. However, the limited resolution of these techniques has precluded the precise identification of detailed specific gene copy number alterations. 相似文献95.
96.
Camacho L Alves MV Bastos JC Felzenszwalb I Cunha Bastos VL 《Bulletin of environmental contamination and toxicology》2000,64(2):191-196
Received: 29 September 1999/Accepted: 30 November 1999 相似文献
97.
OBJECTIVES: To compare seroconversion rates induced by Biken CAM-70 measles vaccines at different viral concentrations. METHODS: Healthy children aged 9 to 18 months from a primary health care unit in Rio de Janeiro, Brazil, and whose guardians agreed with their participation, were randomly assigned to receive one of the following vaccine formulations: 5,000, 1,000 or 200 CCID50 (50% Tissue Culture Infective Dose). The research team, participants, and data analysts were blinded to the type of vaccine administered. Pre- and post-vaccination antibody levels were assessed through Plaque Reduction Neutralization Test. Two interim data analyses were planned to assess unequivocal evidence of the superiority of one of the vaccine types. RESULTS: From 223 recruited children, 84% completed the whole course. Of them, 79% were less than 10 months of age, and 93% did not show detectable measles antibodies in pre-vaccination serum. Seroconversion (four-fold increase in antibody levels) in groups vaccinated with 5,000, 1,000 or 200 CCID50, were 82%, 55%, and 37% (p<0.0000), respectively. Differences in the mean concentration of post-vaccination antibodies were also substantial and statistically significant (p<0.000). Seroconversion rates (pooling data from all vaccine formulations) were 73% to children aged 10 months or more, and 53% in those below 10 months. CONCLUSIONS: Vaccines with concentrations below 5,000 CCID50 did not produce satisfactory seroconversion rates. The vaccine performance by age was consistent with that seen in other studies using Biken CAM-70 strain in which a sizable proportion of 9-month-old children failed to achieve full immunological response. 相似文献
98.
Mackenzie W. Sullivan Fabian T. Camacho Anne M. Mills Susan C. Modesitt 《Gynecologic oncology》2019,152(1):119-126
Objective
The objectives of this study were to analyze factors associated with outcomes and missing data in women with epithelial ovarian cancer using institutional, state and national databases.Methods
Data were abstracted from the University of Virginia cancer registry, Virginia Department of Health (VDH) database, and Surveillance, Epidemiology, and End Results (SEER) Program and analyzed for correlations with demographics, cancer characteristics, and outcomes. Statewide spatial associations between health risk factors such as smoking, obesity, and missing grade/stage were evaluated using bivariate LiSA in Geoda.Results
There were 524 institutional, 3544 VDH, and 44,464 SEER cases of epithelial ovarian cancer. Institutional cases were younger, most often of white race, had increased grade 1, and decreased unknown grade and stage (all p?<?0.001). Significant predictors of unknown grade were non-white race, older age, no surgery, unknown stage/stage IV, and unknown histology/adenocarcinoma. Unknown grade correlated with a significant survival disadvantage. Missing stage and grade correlated with county-level obesity and smoking, as rural regions in Southwest and Southside Virginia had high rates of health risk factors and missing stage/grade compared to urban, affluent regions in Northern Virginia.Conclusions
Over a third of nationally reported cases have an unknown grade and 10–20% have an unknown stage which correlates with the worst survival. Predictors of unknown grade include insurance, age, race, smoking status, obesity, and rural setting. Missing data may represent geographical differences or disparities in cancer care available as significantly fewer cases had an unknown grade/stage at a tertiary academic medical center compared to VDH and SEER. 相似文献99.
F Camacho Martinez J C Moreno Gimenez 《Annales de dermatologie et de vénéréologie》1985,112(2):143-147
Epidermal naevus syndrome is an entity which has been well established by Solomon, Fretzin and Dewald since 1968, presenting cutaneous, visceral, ocular, osseous and neurological malformations. We report a case with multiple osseous manifestations affecting the entire skeleton, but mainly the skull (osteolysis with absence of frontal bone), the vertebral column (scoliosis with triple deviation), the upper right limb (demineralisation and multiple pathological fractures) and lower members (fractures of the right and left femur) with enlargement of the entire ventricular system and well marked scissures, signs of an cortico-subcortical atrophy shown by scanogram. 相似文献
100.
A 19-year-old man with paroxysmal nocturnal hemoglobinuria treated for 3 years with Methandienone was admitted to the hospital with hemoperitoneum due to the rupture of an hepatic tumor. Histology revealed that it was a benign liver cell adenoma, with a pathologic appearance and mode of clinical presentation closely resembling those of cases observed to develop in association to contraceptive steroids. 相似文献