全文获取类型
收费全文 | 6765篇 |
免费 | 379篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 105篇 |
儿科学 | 100篇 |
妇产科学 | 132篇 |
基础医学 | 972篇 |
口腔科学 | 68篇 |
临床医学 | 512篇 |
内科学 | 1307篇 |
皮肤病学 | 283篇 |
神经病学 | 530篇 |
特种医学 | 577篇 |
外科学 | 1037篇 |
综合类 | 40篇 |
一般理论 | 1篇 |
预防医学 | 288篇 |
眼科学 | 180篇 |
药学 | 371篇 |
中国医学 | 4篇 |
肿瘤学 | 674篇 |
出版年
2023年 | 39篇 |
2022年 | 60篇 |
2021年 | 120篇 |
2020年 | 98篇 |
2019年 | 132篇 |
2018年 | 152篇 |
2017年 | 141篇 |
2016年 | 130篇 |
2015年 | 172篇 |
2014年 | 209篇 |
2013年 | 283篇 |
2012年 | 443篇 |
2011年 | 472篇 |
2010年 | 279篇 |
2009年 | 257篇 |
2008年 | 443篇 |
2007年 | 431篇 |
2006年 | 433篇 |
2005年 | 413篇 |
2004年 | 401篇 |
2003年 | 390篇 |
2002年 | 289篇 |
2001年 | 80篇 |
2000年 | 59篇 |
1999年 | 87篇 |
1998年 | 86篇 |
1997年 | 79篇 |
1996年 | 58篇 |
1995年 | 48篇 |
1994年 | 51篇 |
1993年 | 31篇 |
1992年 | 50篇 |
1991年 | 39篇 |
1990年 | 41篇 |
1989年 | 43篇 |
1988年 | 37篇 |
1987年 | 40篇 |
1986年 | 45篇 |
1985年 | 40篇 |
1984年 | 36篇 |
1983年 | 39篇 |
1982年 | 30篇 |
1981年 | 20篇 |
1980年 | 22篇 |
1979年 | 26篇 |
1978年 | 29篇 |
1977年 | 25篇 |
1976年 | 19篇 |
1974年 | 18篇 |
1973年 | 22篇 |
排序方式: 共有7181条查询结果,搜索用时 15 毫秒
121.
122.
Yogesh K Vashist Guentac Uzunoglu Guelle Cataldegirmen Viacheslar Kalinin Paulus Schurr Alexandra M Koenig Sabrina Thieltges Oliver Zehler Claus Schneider Jacob R Izbicki & Emre F Yekebas 《Histopathology》2009,54(3):303-308
Aims: Gastrointestinal stromal tumours (GISTs) display genetic alterations on chromosome 22. GTn repeat (GTn) length polymorphism in the promoter of haeme oxygenase-1 gene ( HMOX-1 ) is located on chromosome 22 and associated with malignant growth. The aim was to investigate the role of HMOX-1 promoter polymorphism in GIST patients.
Methods and results: Tumour and corresponding healthy tissue DNA of 44 patients who underwent surgical resection of GIST were analysed by polymerase chain reaction, capillary electrophoresis and DNA sequencing. GTn polymorphism was classified into short (S) and long (L) allele. There was no difference detected in GTn genotype between tumour and healthy tissue DNA. Short GTn allele (SGTn) was significantly associated with metastatic disease, higher tumour recurrence rates and high risk GIST (consensus criteria 2001). Furthermore, SGTn allele carriers had significantly shorter disease-free and overall survival (log rank test, P < 0.0001). On multivariate Cox regression analysis, GTn polymorphism was identified as an independent prognostic factor for survival ( P = 0.001).
Conclusions: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST. 相似文献
Methods and results: Tumour and corresponding healthy tissue DNA of 44 patients who underwent surgical resection of GIST were analysed by polymerase chain reaction, capillary electrophoresis and DNA sequencing. GTn polymorphism was classified into short (S) and long (L) allele. There was no difference detected in GTn genotype between tumour and healthy tissue DNA. Short GTn allele (SGTn) was significantly associated with metastatic disease, higher tumour recurrence rates and high risk GIST (consensus criteria 2001). Furthermore, SGTn allele carriers had significantly shorter disease-free and overall survival (log rank test, P < 0.0001). On multivariate Cox regression analysis, GTn polymorphism was identified as an independent prognostic factor for survival ( P = 0.001).
Conclusions: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST. 相似文献
123.
124.
We characterized 168 junctional regions of T-cell receptor delta (TCRD) rearrangements from 116 children with acute lymphoblastic leukemia (ALL) (101 with precursor B-cell ALL, 15 with T-cell ALL). Application of 101 allele-specific oligonucleotide (ASO) probes representing 85 Vdelta2Ddelta3, 10 Ddelta2Ddelta3, 3 Vdelta1Jdelta1, 1 Vdelta3Jdelta1, and 2 Ddelta2Jdelta1 junctions for the detection of minimal residual disease (MRD) revealed detection levels of 10(-4) to 10(-6) leukemia cells in the vast majority of cases (93 of 101). Of interest was that neither the N, D, P (nontemplated, diversity, palindromic) content and length of the junctional regions nor the number of nucleotides deleted from the flanking V, D, or J (variable, diversity, joining) elements correlated with the sensitivity of ASO probes. These data indicated that in ALL TCRD rearrangements can serve as suitable tools for the detection of MRD irrespective of the specific composition of the junctional region. 相似文献
125.
126.
Kouriba B Traore HA Dabo A Sangare L Guindo H Keita AS Reimert CM van Dam GJ Deelder AM Doumbo O Dessein AJ 《The Journal of infectious diseases》2005,192(12):2152-2159
BACKGROUND: Schistosoma haematobium infection causes severe urinary disease and considerable mortality. The factors that determine disease progression from mild to severe stages are not fully understood. METHODS: Here we describe a cross-sectional epidemiological study of kidney and bladder diseases in 2 Dogon populations with different exposure to S. haematobium infection. RESULTS: Early and high exposure resulted in more-severe disease, especially among young subjects, without clear evidence of a more-rapid development of immunity. Nevertheless, 50%-60% of subjects of all age classes in both villages showed no evidence of disease. Kidney and bladder disease peaked biphasically among young subjects and adults >25 years old. The first peak corresponded with infections of maximum intensity, whereas the second peak occurred among adults with infections of very low intensity. Kidney disease was correlated with circulating anodic antigen concentration in serum, whereas bladder disease was correlated with egg count and eosinophil cationic protein concentration in urine. Kidney and bladder disease did not correlate. Severe kidney disease was more frequent in certain families. CONCLUSIONS: The frequency of urinary disease is increased by infections acquired early during life, is regulated by strong clinical immunity in certain subjects, and may be dependent on hereditary factors. Kidney and bladder disease may involve different mechanisms of pathogenesis, which may differ between children and adults. 相似文献
127.
128.
Biatrial multisite mapping of atrial premature complexes triggering onset of atrial fibrillation 总被引:7,自引:0,他引:7
Schmitt C Ndrepepa G Weber S Schmieder S Weyerbrock S Schneider M Karch MR Deisenhofer I Schreieck J Zrenner B Schömig A 《The American journal of cardiology》2002,89(12):127-1387
Pulmonary veins are considered to be the most common origin of the focal activity that triggers the onset of atrial fibrillation (AF). However, little is known about the importance of ectopic activity located outside the pulmonary veins. This study included 45 patients (8 women and 37 men, mean age 55 ± 12 years) with paroxysmal (n = 25) and persistent (n = 20) AF in whom multisite mapping of the right and left atria was performed using a 64-electrode basket catheter (n = 21) or a noncontact mapping system (n = 24). Spontaneous or orciprenaline-induced atrial premature complexes (APCs) were mapped. In all, 94 AF onsets from 38 distinct foci in 30 patients were observed and analyzed. Of these foci, 20 (53%) were located in pulmonary veins and 18 (47%) were located outside the pulmonary veins in other parts of the atria. In 22 patients (73%), AF was reproducibly induced by APCs from a single focus (59 episodes). In 8 patients (27%), AF originated from 2 distinct foci (35 episodes). Additionally, 20 of 30 patients (67%) who developed AF had APCs in different locations not inducing AF. APCs inducing AF had shorter coupling intervals than APCs not inducing AF (307 ± 54 vs 409 ± 76 ms, p <0.001). This study showed that 47% of ectopic foci triggering the onset of AF were located outside the pulmonary veins in extravenous parts of the left atrium and the right atrium, and 27% of patients had AF onsets of bifocal origin. These data challenge the current opinion that extrapulmonary foci play a minor role in inducing AF. 相似文献
129.
In humans, maternal hypercholesterolemia during pregnancy promotes microscopical fatty streaks in the children. The mechanism is unknown. Fatty streaks are clinically silent, and many of them regress and never develop into advanced atherosclerosis. The aim of this study was to investigate whether hypercholesterolemia in pregnant mice induced more advanced atherosclerosis in their adult progeny. Hypercholesterolemic (HC) apolipoprotein E knockout (apoE(-/-)) female mice were mated with normocholesterolemic (NC) wild-type (apoE(+/+)) males and vice versa. All parents were almost identical genetically except for apoE. Therefore, all progeny became genetically identical and heterozygous apoE(+/-). They were born of either HC (i.e. apoE(-/-)) or NC (i.e. apoE(+/+)) mothers. The progeny were killed 6 months after birth and the amount of atherosclerosis in the aortic root was assessed. Females developed more atherosclerosis than males (P<0.001) but, regardless of sex, maternal hypercholesterolemia during pregnancy had no influence on the amount of atherosclerosis in adult progeny. Males of HC mothers had lower plasma cholesterol levels than males of NC mothers. Thus, in mice, maternal hypercholesterolemia during pregnancy does not promote the development of advanced atherosclerosis in their adult progeny. 相似文献
130.
Evaluation of an ICD‐10 algorithm to detect osteonecrosis of the jaw among cancer patients in the Danish National Registry of Patients
下载免费PDF全文
![点击此处可从《Pharmacoepidemiology and drug safety》网站下载免费的PDF全文](/ch/ext_images/free.gif)