Cyclopeptides with anti-inflammatory activity from seeds of Annona montana

Four new cyclopeptides, cyclomontanins A-D (1- 4), annomuricatin C (5), and (+)-corytuberine were isolated from a methanol extract of Annona montana seeds. Their structures were elucidated by 2D NMR analysis, ESIMS/MS fragment evidence, and chemical means. The structure of 1 was confirmed by synthesis. Compounds 1, 3, and 4 exhibited anti-inflammatory activity in vitro using the J774.1 macrophage model.     

Vaginal cuff endometriosis resulting in a fistula between the vagina and abdominal cavity and presenting as peritonitis: a case report

BACKGROUND: The specimen from a vaginal cuff fistula between the vagina and abdominal cavity revealed endometriosis. Culture of the fluid revealed Streptococcus viridans. CASE: A 44-year-old woman presented with lower abdominal pain for 1 week. She also had cyclic vaginal spotting that had started 1 month after she underwent laparoscopically assisted vaginal hysterectomy for a myoma 2 years earlier. One year prior to this admission, she was noted to have a right endometrioma on a sonographic examination; monthly follow-up revealed that the cyst was enlarging. The patient was admitted for surgery. On laparotomy, severe adhesions were noted. After adhesiolysis, a right adnexal cyst with chocolatelike contents mixed with malodorous, yellowish, mucoid fluid was noted. A vaginal cuff fistula between the vagina and abdominal cavity was also noted. The specimen from this area revealed endometriosis. Culture of the fluid showed Streptococcus viridans. CONCLUSION: Various laparoscopic complications are cited in the literature. Although rare, the risk of infection after laparoscopy can occur. In our case the infection may have been caused by the presence of vaginal cuff fistula in the presence of endometriosis.     

胆囊切除术后腹泻的研究进展

胆囊切除术后腹泻(PCD)是胆囊切除术后综合征(PCS)的常见症状之一,不仅发病率高,且严重影响患者的工作和生活。因此,PCD的治疗已逐渐成为研究热点。然而,目前PCD的发病机制及其治疗方法尚不明确。本文就PCD的相关流行病学、病理生理、发病机制及治疗策略等方面进行综述。     

中医疗法结合3D打印技术治疗中重度肘管综合征

目的:观察应用3D打印技术指导下的尺神经沟扩大成形术结合尺神经原位松解,术后给予针刺促进神经康复来治疗中重度肘管综合征的临床疗效.方法:自2016年4月—2019年3月,对40例由于肘关节退行性病变引起的尺神经沟骨赘生成造成尺神经卡压的中重度肘管综合征患者,根据其术前肘关节CT平扫三维重建应用3 D打印技术打印肘关节模...     

胸痛特征诊断冠心病的准确性

目的 探讨胸痛特征诊断冠心病的准确性.方法 连续入组2012年6月至2016年6月经过冠状动脉造影(CAG)和冠状动脉血流储备分数(FFR)检查的住院患者240例,根据临床病史的描述将患者分成无胸痛组(55例),不典型胸痛组(79例),典型劳力心绞痛组(64例)和支架植入组(42例).将不同胸痛性质与CAG和FFR进行...     

日本J-Stage国家期刊传播平台与期刊语种影响研究

【目的】 以J-Stage平台的概况和日本科技期刊的语种分类为基础,深入分析J-Stage的实施细节及其在推动日本科技期刊发展中的关键作用与角色,对我国期刊发展形成启示。【方法】 采用前瞻研究法,从平台架构、组织和功能方面分析J-Stage的发展现状,并结合日本科技期刊的语种分类进行分析。【结果】 J-Stage的特色在于整合全国学术期刊资源、采取公益性运行机制、重视用户体验、不断更新服务、对接国际标准等,对我国期刊平台建设具有一定的借鉴意义。【结论】 J-Stage的建设有利于日本多语种科技期刊的共同发展和国际影响力提升。国家级科技期刊平台不仅是期刊发展的基础设施,还要兼具前瞻性导向作用和精益管理能力。     

The effects of desipramine, zimelidine, electroconvulsive treatment and lithium on rat brain biogenic amines: a comparison with peripheral changes

The effects of 4 common treatments for affective disorders on total body norepinephrine (NE) and dopamine (DA) turnover and metabolism were evaluated in rats. The treatments were chronic desipramine (DMI), zimelidine (ZMI), electroconvulsion (ECT) and lithium (Li). The central effects of ECT and Li were also assessed in the brain. The results obtained were compared with the effects of these 4 treatments on total NE (Sum NE) and DA (Sum DA) turnover in depressed patients. We have also evaluated central and/or peripheral effects of these treatments on phenylethylamine, p-tyramine and serotonin metabolism. The urinary changes in Sum NE and DA observed after DMI, ZMI and Li in the rat were similar to those found in depressed patients; Sum NE was significantly reduced. In contrast to its effects on depressed patients, chronic ECT significantly increased Sum NE. Similar to depressed patients, ECT reduced the fraction of NE escaping re-uptake in the rat. Sum DA was not affected by DMI, ZMI or ECT, but was significantly reduced by chronic Li treatment. All 4 treatments significantly reduced serotonin metabolism as indicated by reduced 5-hydroxyindoleacetic acid excretion rates. DMI, ZMI and Li treatments significantly reduced phenylethylamine urinary but not p-tyramine urinary outputs. The opposite effect was observed after ECT. Consistent with their effects on Sum NE, Li reduced while ECT increased hypothalamic NE turnover as deduced from the changes in 3-methoxy-4-hydroxyphenylglycol's rate of formation. As for Sum DA, Li had no effect on 3,4-dihydroxyphenylacetic acid or homovanillic acid's rates of formation in the caudate nucleus. Chronic ECT produced a small, but significant increase in homovanillic acid's rate of formation in the caudate nucleus.     

Solitary cavities of the lung: diagnostic implications of cavity wall thickness

Sixty-five solitary cavities of the lung were evaluated for wall thickness. All lesions in which the thickest part of the cavity wall was 1 mm were benign. Of the lesions whose thickest measurement was 4 mm or less, 92% were benign. Of cavities that were 5-15 mm in their thickest part, 51% were benign and 49% malignant. Of those over 15 mm thick, 95% were malignant. Measurement of the thickest part of te cavity wall gives a more reliable indication of benignancy or malignancy than measurement of the thinnest part.