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排序方式: 共有638条查询结果,搜索用时 31 毫秒
631.
Tan To Cheung Ferdinand S. K. Chu Caroline R. Jenkins Dickson S. F. Tsang Kenneth S. H. Chok Albert C. Y. Chan Thomas C. C. Yau See Ching Chan Ronnie T. P. Poon Chung Mau Lo Sheung Tat Fan 《World journal of surgery》2012,36(10):2420-2427
Background
High-intensity focused ultrasound (HIFU) ablation is a relatively new, noninvasive way of ablation for treating hepatocellular carcinoma (HCC). Emerging evidence has shown that it is effective for the treatment of HCC, even in patients with poor liver function. There is currently no data on the safety limit of HIFU ablation in patients with cirrhosis. However, this information is vital for the selection of appropriate patients for the procedure. We analyzed HCC patients who had undergone HIFU ablation and determined the lower limit of liver function and other patient factors with which HCC patients can tolerate this treatment modality.Methods
Preoperative variables of 100 patients who underwent HIFU ablation for HCC were analyzed to identify the risk factors in HIFU intolerance in terms of stress-induced complications. Factors that may contribute to postablation complications were compared.Results
Thirteen (13?%) patients developed a total of 18 complications. Morbidity was mainly due to skin and subcutaneous tissue injuries (n?=?9). Five patients had first-degree skin burn, one had second-degree skin burn, and three had third-degree skin burn. Four complications were grade 3a in the Clavien classification and 14 were below this grade. Univariate analysis showed that age (p?=?0.022) was the only independent factor in HIFU intolerance.Conclusions
HIFU ablation is generally well tolerated in HCC patients with cirrhosis. It is safe for Child-Pugh A and B patients and selected Child-Pugh C patients. With this new modality, HCC patients who were deemed unsalvageable by other surgical means in the past because of simultaneous Child-Pugh B or C disease now have a new hope. 相似文献632.
633.
Children and adolescents with marginal zone lymphoma have an excellent prognosis with limited chemotherapy or a watch‐and‐wait strategy after complete resection
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Leila Ronceray Oussama Abla Shlomit Barzilai‐Birenboim Simon Bomken Alan KS Chiang Janez Jazbec Edita Kabickova Jelena Lazic Auke Beishuizen Karin Mellgren Fumiko Tanaka Marta Pillon Christine Devalck Marina Gouttenoire Olga Makarova Birgit Burkhardt Andishe Attarbaschi 《Pediatric blood & cancer》2018,65(4)
Data on management of pediatric marginal zone lymphoma (MZL) are scarce. This retrospective study assessed characteristics and outcome in 66 patients who were <18 years old. Forty‐four (67%) had an extranodal MZL (EMZL), 21 (32%) a nodal MZL (NMZL), and one patient a splenic MZL. Thirty‐three patients (50%) received a variable combination of adjuvant chemotherapy/immunotherapy/radiotherapy, while the remainder, including 20 of 21 with NMZL, entered an active observation period. Overall survival was excellent (98 ± 2%), although 11 patients relapsed (17%; NMZL, n = 1; EMZL, n = 10), seven after any therapy and four after complete resection only. In conclusion, outcome of NZML, in particular, seems to be excellent after (in)complete resection and observation only. 相似文献
634.
Minimally invasive surgery potentially reduces operative morbidities. However, pure laparoscopic approaches to donor hepatectomy have been limited by technical complexity and concerns over donor safety. Reducedwound donor hepatectomy, either in the form of a laparoscopic-assisted technique or by utilizing a minilaparotomy wound, i.e., hybrid approach, has been developed to bridge the transition to pure laparoscopic donor hepatectomy, offering some advantages of minimally invasive surgery. To date, pure laparoscopic donor left lateral sectionectomy has been validated for its safety and advantages and has become the standard in experienced centres. Pure laparoscopic approaches to major left and right liver donation have been reported for their technical feasibility in expert hands. Robotic-assisted donor hepatectomy also appears to be a valuable alternative to pure laparoscopic donor hepatectomy, providing additional ergonomic advantages to the surgeon. Existing reports derive from centres with tremendous experience in both laparoscopic hepatectomy and donor hepatectomy. The complexity of these procedures means an arduous transition from technical feasibility to reproducibility. Donor safety is paramount in living donor liver transplantation. Careful donor selection and adopting standardized techniques allow experienced transplant surgeons to safely accumulate experience and acquire proficiency. An international prospective registry will advance the understanding for the role and safety of pure laparoscopic donor hepatectomy. 相似文献
635.
Suppression of mouse skin tumor promotion and induction of apoptosis in HL-60 cells by Alpinia oxyphylla Miquel (Zingiberaceae) 总被引:3,自引:0,他引:3
There have been considerable efforts to search for naturally occurring
substances for the intervention of carcinogenesis. Many components from
dietary or medicinal plants have been identified that possess substantial
chemopreventive properties. An example is curcumin (Curcuma longa Linn.,
Zingiberaceae), which has been shown to inhibit tumor promotion in
experimental carcinogenesis. Alpinia oxyphylla Miquel, another plant of the
ginger family used in oriental herbal medicine, contains diarylheptanoids
whose structures are analogous to that of curcumin. In the present study,
we have tested A.oxyphylla for its ability to suppress tumor promotion.
Thus, topical application of the methanolic extract of dried fruits of
A.oxyphylla significantly ameliorated 12-O-tetradecanoylphorbol-13-acetate
(TPA)-induced skin tumor promotion as well as ear edema in female ICR mice.
In another study, treatment of HL-60 cells with the methanolic extract of
A.oxyphylla significantly reduced the viability of the cells and also
inhibited DNA synthesis. Microscopic examination of the treated cells
showed characteristic morphology of apoptosis. Furthermore, cells treated
with the extract of A.oxyphylla exhibited internucleosomal DNA
fragmentation in time- and concentration-dependent manners. TPA- stimulated
generation of superoxide anion in differentiated HL-60 cells was also
blunted by A.oxyphylla. Taken together, these findings suggest that
A.oxyphylla possesses potential chemopreventive and antitumorigenic
activities.
相似文献
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