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991.
ProteinChip array profiling for identification of disease- and chemotherapy-associated biomarkers of nasopharyngeal carcinoma 总被引:4,自引:0,他引:4
Cho WC Yip TT Ngan RK Yip TT Podust VN Yip C Yiu HH Yip V Cheng WW Ma VW Law SC 《Clinical chemistry》2007,53(2):241-250
BACKGROUND: We previously used ProteinChip array profiling analysis to discover a serum biomarker associated with nasopharyngeal carcinoma (NPC). In this study, we used the same method to examine other biomarkers associated with NPC and response to chemotherapy (CT) in NPC patients. METHODS: We performed ProteinChip array analysis in 209 serum samples from 66 relapsed patients before and after salvage CT with gemcitabine and cisplatin or etoposide and cisplatin combinations, 11 patients in remission, and 35 healthy individuals. Intensities of the biomarker peaks were correlated with CT response of the patients and other clinical parameters. RESULTS: We discovered 13 candidate biomarkers associated with different clinical parameters. Two biomarkers (2803 and 3953 Da) were significantly increased in patients compared with controls at all stages of disease. Analysis of pre- and post-CT paired serum samples revealed 7 biomarkers correlated with impact of CT. Of these 7 biomarkers, 2 (2509 and 2756 Da) were significantly increased and 5 (7588, 7659, 7765, 7843, and 8372 Da) were significantly decreased post-CT in either 1 or both CT cohorts. Four biomarkers from pre-CT sera were correlated with CT response, with 3 (2950, 13 510, and 14 855 Da) being significantly decreased and 1 (6701 Da) significantly increased in patients who did not respond to CT. Tandem mass spectrometric sequencing and/or immunoaffinity capture assay identified the 3953 Da biomarker as a fragment of interalpha-trypsin inhibitor precursor and 7765 Da biomarker as platelet factor-4. CONCLUSIONS: Treatment-associated serum biomarkers found might serve to triage NPC patients for appropriate CT treatment. 相似文献
992.
Kin Fen Kevin Fung Anthony Pak-Yin Liu Patrick Ho-Yu Chung Ka King Cheng Hing Yan Danny Cho Yee Ling Elaine Kan Alan Kwok Shing Chiang 《Pediatric blood & cancer》2023,70(1):e30019
This brief report aims to evaluate the treatment outcome of transarterial embolization in ruptured hepatoblastoma complicated with acute intra-abdominal hemorrhage. Three children (mean age 6 years) with high-risk hepatoblastoma presented with rupture and acute intra-abdominal hemorrhage. In addition to aggressive fluid resuscitation and blood product support, super-selective embolization of the arteries with active bleeding or pseudoaneurysm was performed using calibrated gelfoam particles, with a technical success rate of 100%. Hemodynamic status and hemoglobin level were normalized in all patients within 2 days postembolization. The 30-day survival rate was 100%. No major complication was detected apart from mild elevation of alanine transaminase. 相似文献
993.
994.
Kumar Naresh Liu Zhong Jun Poon Wai Sang Park Chun-Kun Lin Ruey-Mo Cho Kyoung-Suok Niu Chi Chien Chen Hung Yi Madhu Sirisha Shen Liang Sun Yu Mak Wai Kit Lin Cheng Li Lee Sang-Bok Park Choon Keun Lee Dong Chan Tung Fu-I Wong Hee-Kit 《European spine journal》2022,31(5):1260-1272
European Spine Journal - Our study aimed to evaluate non-inferiority of ProDisc-C to anterior cervical discectomy and fusion (ACDF) in terms of clinical outcomes and incidence of adjacent segment... 相似文献
995.
996.
Kim Jae Hui Kim Chul Gu Lee Dong Won Yoo Su Jin Lew Young Ju Cho Han Joo Kim Joo Yeon Lee Seok Hyun Kim Jong Woo 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(1):107-116
Graefe's Archive for Clinical and Experimental Ophthalmology - To evaluate the efficacy of intravitreal aflibercept monotherapy for submacular hemorrhage secondary to neovascular age-related... 相似文献
997.
Sooyoung Kim Tae H. Park Woo I. Kim Suyeon Park Jae H. Kim Moon K. Cho 《Phytotherapy research : PTR》2021,35(1):374-383
Green tea extract (GTE) has been studied for the treatment of acne based on its anti‐inflammatory/antioxidant properties. This systematic review and meta‐analysis aimed to examine the effects of GTE on acne. Electronic databases, including PubMed, Embase, and the Cochrane Library were systematically searched up to August 2019. The effect size of acne lesion counts is presented as mean differences and 95% confidence intervals (CIs). Five randomized‐controlled studies were included in the meta‐analysis (N; experimental = 125, control = 122). GTE significantly reduced the number of inflammatory lesions (?9.38; 95% CI: ?14.13 to ?4.63). In subgroup analysis, topical GTE application significantly reduced the inflammatory lesion counts (?11.39; 95% CI: ?15.91 to ?6.86) whereas oral GTE intake showed minimal effect (?1.40; 95% CI: ?2.50 to ?0.30). Although GTE did not significantly reduce the number of non‐inflammatory lesions (?21.65; 95% CI: ?47.52 to 4.22), when stratified by the route of admission, non‐inflammatory acne lesions were significantly reduced by topical GTE application (?32.44; 95% CI: ?39.27 to ?25.62) but not with oral GTE administration (0.20; 95% CI: 0.00 to 0.40). This systematic review and meta‐analysis suggest that topical GTE application is beneficial for the treatment of acne without causing significant adverse events while oral GTE intake has limited effects. Further high‐quality clinical trials are warranted. 相似文献
998.
Extramedullary hematopoiesis (EMH) is most often associated with underlying hematologic disorders, such as myeloproliferative neoplasms and thalassemia. EMH in the setting of solitary fibrous tumor (SFT) is exceedingly rare, with only 3 cases reported to date in the English literature. Herein, we describe our experience with a unique case of SFT arising in the breast with intratumoral foci of EMH in a 57‐year‐old woman who presented with an incidentally found right axillary mass on routine screening mammography. To the best of our knowledge, this is the first reported case of mammary SFT with concurrent intratumoral EMH. 相似文献
999.
1000.