全文获取类型
收费全文 | 111614篇 |
免费 | 11408篇 |
国内免费 | 7474篇 |
专业分类
耳鼻咽喉 | 950篇 |
儿科学 | 1384篇 |
妇产科学 | 1514篇 |
基础医学 | 12308篇 |
口腔科学 | 1954篇 |
临床医学 | 13301篇 |
内科学 | 16467篇 |
皮肤病学 | 1241篇 |
神经病学 | 5195篇 |
特种医学 | 4356篇 |
外国民族医学 | 54篇 |
外科学 | 12307篇 |
综合类 | 20144篇 |
现状与发展 | 23篇 |
一般理论 | 18篇 |
预防医学 | 8347篇 |
眼科学 | 2736篇 |
药学 | 12125篇 |
92篇 | |
中国医学 | 7019篇 |
肿瘤学 | 8961篇 |
出版年
2024年 | 385篇 |
2023年 | 1609篇 |
2022年 | 4122篇 |
2021年 | 5337篇 |
2020年 | 4095篇 |
2019年 | 3589篇 |
2018年 | 3733篇 |
2017年 | 3495篇 |
2016年 | 3411篇 |
2015年 | 4898篇 |
2014年 | 5959篇 |
2013年 | 5900篇 |
2012年 | 7892篇 |
2011年 | 8479篇 |
2010年 | 5722篇 |
2009年 | 4555篇 |
2008年 | 5700篇 |
2007年 | 6145篇 |
2006年 | 5760篇 |
2005年 | 5191篇 |
2004年 | 4885篇 |
2003年 | 5257篇 |
2002年 | 4713篇 |
2001年 | 3849篇 |
2000年 | 3010篇 |
1999年 | 2419篇 |
1998年 | 1401篇 |
1997年 | 1359篇 |
1996年 | 1017篇 |
1995年 | 885篇 |
1994年 | 770篇 |
1993年 | 494篇 |
1992年 | 707篇 |
1991年 | 586篇 |
1990年 | 541篇 |
1989年 | 484篇 |
1988年 | 375篇 |
1987年 | 353篇 |
1986年 | 273篇 |
1985年 | 225篇 |
1984年 | 142篇 |
1983年 | 105篇 |
1982年 | 70篇 |
1981年 | 89篇 |
1980年 | 49篇 |
1979年 | 77篇 |
1978年 | 37篇 |
1974年 | 36篇 |
1973年 | 33篇 |
1972年 | 41篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
72.
73.
AbstractCadmium (Cd) as environmental pollutant can induce severe damage, particularly to the testis. This study investigated the effects of Caffeic acid phenethyl ester (CAPE) on testicular dysfunction induced by Cd. Adult mice were intraperitoneally injected with cadmium chloride (CdCl2) with different doses of CAPE pretreatment. After CdCl2 injection, body/testis weight ratio decreased, Cd levels accumulated and zinc levels decreased in testis. Furthermore, Cd intoxication caused a significant increase of oxidative stress levels, antioxidant enzymes activities, and glutathione levels. Interestingly, significant improvements were observed after the administration of CAPE. Our results demonstrated the protective effect of CAPE, linking Cd testicular dysfunction to oxidative stress. 相似文献
74.
75.
Zhengxian Huang Nan Xie Haichao Liu Yuehan Wan Yue Zhu Ming Zhang Yifan Tao Han Zhou Xiqiang Liu Jinsong Hou Cheng Wang 《Journal of oral pathology & medicine》2019,48(9):788-798
It has been suggested that tumour‐infiltrating lymphocytes (TILs) are associated with the progression of oral squamous cell carcinoma (OSCC). However, the prognostic value of TILs is inconclusive due to the heterogeneity of immune cells within the tumour microenvironment. In this meta‐analysis, we aimed to assess the prognostic value of TILs in OSCC. The PubMed, Cochrane, Embase, Scopus and Web of Science databases were searched up to April 20, 2019, and 33 studies were ultimately included in this meta‐analysis. Our pooled meta‐analysis showed that high infiltration of CD8+ TILs, CD45RO+ TILs and CD57+ TILs favoured better overall survival (OS). However, high infiltration of CD68+ macrophages and CD163+ macrophages was associated with poor prognosis in OSCC. These findings suggest that CD8+ TILs, CD45RO+ TILs, CD57+ TILs, CD68+ macrophages and CD163+ macrophages might serve as novel prognostic factors and therapeutic targets in OSCC. 相似文献
76.
Stereotactic body radiotherapy (SBRT) has become an important radiotherapy technology. In recent years, with the continuous improvement of the mechanical properties of the linear accelerator (LINAC), LINAC-based SBRT is gradually emerging. In this article, the history, technological progress, radiation physics, clinical application of LINAC-based SBRT were elaborated, aiming to promote the development of LINAC-based SBRT. 相似文献
77.
OBJECTIVES: To assess the effectiveness and safety of additional bedtime H2‐receptor antagonists (H2RAs) in suppressing nocturnal gastric acid breakthrough (NAB) via a systematic review. METHODS: Eligible trials were identified by searching the Cochrane Central Register of Controlled Trials (CENTRAL) (Cochrane Library Issue 2, 2004), MEDLINE (January 1966–June 2004), EMBASE (January 1980–June 2004) and CINAHL (January 1982–June 2004). Additional hand‐searching was conducted on the proceedings of correlated conferences, eight important Chinese journals and references of all included trials. All randomized controlled trials evaluating H2RAs for the control of NAB were eligible for inclusion. The systematic review was conducted using methods recommended by The Cochrane Collaboration. RESULTS: Only two randomized crossover studies, comprising 32 participants, met the inclusion criteria. Because the design, dosage and duration of the treatments were different between the studies, it was not possible to conduct meta‐analysis. There were no consistent conclusions found between the two included studies in evaluating H2RAs for the control of NAB. CONCLUSIONS: No implications for practice at this stage can be concluded. Appropriately designed large‐scale randomized controlled trials with long‐term follow up are needed to determine the effects of additional bedtime H2RAs in suppressing NAB. 相似文献
78.
目的:构建一种可以在哺乳动物细胞中蜕皮激素诱导表达截短型hIGF-Ⅰ的受控型转基因载体,为制备受控型蜕皮激素诱导表达截短型MGF-Ⅰ的转基因小鼠奠定基础。方法:利用分子克隆技术构建受控型蜕皮激素诱导表达截短型hIGF-Ⅰ的转基因载体;将其电转至AM1菌中,利用其中的Cre重组酶将载体上两个同向LoxP序更锚定的新霉素(neomycin)基因删除,解除其对蜕皮激素诱导表达系统的阻断作用,利用PCR、酶切和测序鉴定删除情况;将重组后的载体转染至COS7细胞中进行瞬间表达,蜕皮激素诱导后回收培养上清和细胞裂解物进行Western印迹分析,检测hIGF-Ⅰ的表达情况。结果和结论:成功构建大小为13.6kb的转基因载体pOE-IGF-Ⅰ;转化至AM1中后,PCR、酶切和测序的结果都证明其中的Cre酶能够将载体上neomycin基因删除;重组后的载体转染至COS7细胞中进行诱导表达,Western印迹实验证明截短型MGF-Ⅰ能够在COS7细胞中顺利表达。上述结果证明该蜕皮激素诱导表达截短型hIGF-Ⅰ的受控型转基因载体能够用于转基因小鼠的制备。 相似文献
79.
Meng Qingyue Li Renzhong Cheng Gang 《中国防痨杂志》2003,25(Z1):22-23
INTRODUCTION: The financial responsibility in health sector was decentralizedfrom central and provincial governments to county and township governments. It was argued that a decentralized system without effective transfer payment mechanism has pushed the poverty area to more disadvantaged positions in economic development in general. 相似文献
80.
应用64层CT一次扫描完成心脏冠脉成像及心功能分析的可行性初步研究 总被引:1,自引:0,他引:1
目的研究64层CT一次扫描同时完成心脏冠脉成像及心功能分析的可行性。方法96例患者均行MSCT心脏成像扫描和MR心脏检查,数据分别按照冠脉成像和心功能分析要求进行重建和后处理,评估。结果1271段冠脉血管中有约99%血管显示清晰,达到诊断要求;心功能分析数据左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左室每搏输出量(LVSV)、左室射血分数(LVEF)、左室心肌容积(LVMV)与MR相关数据的相关系数分别为0.84、0.91、0.94、0.89、0.88。结论MSCT可以在一次扫描中完成冠脉成像和心功能数据采集,具有极高应用价值。 相似文献