全文获取类型
收费全文 | 346篇 |
免费 | 8篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 9篇 |
妇产科学 | 15篇 |
基础医学 | 46篇 |
口腔科学 | 3篇 |
临床医学 | 22篇 |
内科学 | 98篇 |
皮肤病学 | 7篇 |
神经病学 | 33篇 |
特种医学 | 4篇 |
外科学 | 41篇 |
综合类 | 2篇 |
预防医学 | 16篇 |
眼科学 | 9篇 |
药学 | 5篇 |
中国医学 | 1篇 |
肿瘤学 | 29篇 |
出版年
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 4篇 |
2013年 | 3篇 |
2012年 | 28篇 |
2011年 | 30篇 |
2010年 | 10篇 |
2009年 | 9篇 |
2008年 | 39篇 |
2007年 | 48篇 |
2006年 | 48篇 |
2005年 | 31篇 |
2004年 | 31篇 |
2003年 | 43篇 |
2002年 | 12篇 |
2001年 | 1篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1986年 | 1篇 |
排序方式: 共有354条查询结果,搜索用时 15 毫秒
61.
S.-N. Tran Ba O. Lidove R. Dorent M. Debauchez P. Nataf M. Delahousse A. Karras L. Azeroual P. De Lentdecker M.P. Chauveheid T. Sené J.-M. Ziza 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2017,38(2):137-142
Introduction
Fabry disease is a lysosomal storage disorder linked to an alpha-galactosidase A deficiency that can lead to heart and kidney failure. There is little data about the prognosis of patients who undergo a combined heart and kidney transplantation.Case reports
Two brothers who were diagnosed with Fabry disease after the age of 30 years underwent a combined heart and kidney transplantation at respectively 49 and 42 years of age because of a severe hypertrophic cardiomyopathy with end stage renal failure. They are alive respectively 4 and 9 years after the transplantation. No recurrence of the disease in the transplanted organs has been found.Conclusion
Combined heart and kidney transplantation in Fabry disease is an efficient therapy for the cardiomyopathy and kidney failure. Its prognosis can be good when the patients are carefully selected. However, an early diagnosis is critical in order to avoid a procedure associated with a high perioperative mortality. 相似文献62.
Serova M Bieche I Sablin MP Pronk GJ Vidaud M Cvitkovic E Faivre S Raymond E 《British journal of cancer》2011,105(2):272-280
Background:
Pralatrexate is a dihydrofolate reductase (DHFR) inhibitor with high affinity for reduced folate carrier 1 (RFC-1) and folylpolyglutamate synthetase (FPGS), resulting in extensive internalization and accumulation in tumour cells. Pralatrexate is approved in the US for the treatment of relapsed or refractory peripheral T-cell lymphoma and is being investigated in various malignancies. Here, we evaluated molecular correlates of sensitivity to pralatrexate and explored combinations with a variety of anticancer agents.Methods:
Antiproliferative effects of pralatrexate were evaluated in 15 human-cancer cell lines using the MTT assay. Gene expression was evaluated using qRT–PCR.Results:
Pralatrexate and methotrexate had a similar pattern of cytotoxicity, pralatrexate being more potent. Pralatrexate potentiated the effects of platinum drugs, antimetabolites and EGFR inhibitors. Dose- and time-dependent cytotoxicity of pralatrexate correlated with high mRNA expression of FPGS. Acquired resistance to pralatrexate was associated with decreased RFC-1 expression, whereas methotrexate resistance correlated with increased DHFR expression, suggesting different mechanisms of acquired resistance.Conclusion:
Pralatrexate was more potent than methotrexate in a panel of solid tumour lines. Our findings support the further clinical development of pralatrexate in combination with certain cytotoxics and targeted therapies, and suggest that RFC-1, FPGS and DHFR may be potential biomarkers of outcome. 相似文献63.
64.
Reboul MP Tandonnet O Biteau N Belet-de Putter C Rebouissoux L Moradkhani K Vu PY Saura R Arveiler B Lacombe D Taine L Iron A 《Clinical genetics》2006,70(3):207-213
Uniparental disomy (UPD) for several human chromosomes is associated with clinical abnormalities. We report the case of a 2-year-old boy with severe intrauterine and post-natal growth retardation (IUGR/PNGR) and highly variable sweat chloride concentrations. The patient was identified as heterozygous for the F508del mutation of the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Unexpectedly, the signal corresponding to the maternally inherited F508del allele appeared much more intense than the paternally derived wild allele. Molecular analysis including polymorphic marker studies, microsatellites and single-nucleotide polymorphisms subsequently showed that the boy was a carrier of a de novo mosaic maternal isodisomy of a chromosome 7 segment while there was a biparental inheritance of the rest of the chromosome. This is the first report of a mosaic partial UPD7. The matUPD7 segment at 7q21-qter extends for 72.7 Mb. The karyotype (550 bands) of our patient was normal, and fluorescence in situ hybridization with probes mapping around the CFTR gene allowed us to rule out a partial duplication. The detection of this chromosomal rearrangement confirms the hypothesis that the 7q31-qter segment is a candidate for the localization of human imprinted genes involved in the control of IUGR and PNGR. It also emphasizes the importance of searching for UPD7 in severe, isolated and unexplained IUGR and PNGR. 相似文献
65.
66.
Classe JM Baffert S Sigal-Zafrani B Fall M Rousseau C Alran S Rouanet P Belichard C Mignotte H Ferron G Marchal F Giard S Tunon de Lara C Le Bouedec G Cuisenier J Werner R Raoust I Rodier JF Laki F Colombo PE Lasry S Faure C Charitansky H Olivier JB Chauvet MP Bussières E Gimbergues P Flipo B Houvenaeghel G Dravet F Livartowski A 《Annals of oncology》2012,23(5):1170-1177
BackgroundOur objective was to assess the global cost of the sentinel lymph node detection [axillary sentinel lymph node detection (ASLND)] compared with standard axillary lymphadenectomy [axillary lymph node dissection (ALND)] for early breast cancer patients.Patients and methodsWe conducted a prospective, multi-institutional, observational, cost comparative analysis. Cost calculations were realized with the micro-costing method from the diagnosis until 1 month after the last surgery.ResultsEight hundred and thirty nine patients were included in the ASLND group and 146 in the ALND group. The cost generated for a patient with an ASLND, with one preoperative scintigraphy, a combined method for sentinel node detection, an intraoperative pathological analysis without lymphadenectomy, was lower than the cost generated for a patient with lymphadenectomy [€2947 (σ = 580) versus €3331 (σ = 902); P = 0.0001].ConclusionASLND, involving expensive techniques, was finally less expensive than ALND. The length of hospital stay was the cost driver of these procedures. The current observational study points the heterogeneous practices for this validated and largely diffused technique. Several technical choices have an impact on the cost of ASLND, as intraoperative analysis allowing to reduce rehospitalization rate for secondary lymphadenectomy or preoperative scintigraphy, suggesting possible savings on hospital resources. 相似文献
67.
A-M. Gagné J. Lavoie M-P. Lavoie A. Sasseville M-C. Charron M. Hébert 《Documenta ophthalmologica. Advances in ophthalmology》2010,121(3):167-175
We investigated the possibility of performing electroretinography (ERG) in non-pharmacologically dilated eyes using brighter
flash (time-integrated) luminance. Photopic (N = 26; background 25.5 cd·m−2, white LED flashes) and scotopic ERG (N = 23, green LED flashes) luminance response functions were obtained simultaneously in a dilated (DE) and non-dilated eye
(NDE). In the NDE, photopic V
max b-wave amplitude was reduced by 14% (P < 0.0001), implicit time prolonged (P < 0.0001), and retinal sensitivity (log K) decreased by 0.38 log units (P < 0.0001) with no effect on a-wave. Using a xenon strobe light (N = 6) to increase flash luminance, V
max remained lower by about 12% in the NDE (P = 0.02). V
max with LED and xenon was achieved at 3.9 ± 1.0 cd·s·m−2 and 3.3 ± 0.81 cd·s·m−2 in the DE and 10.6 ± 1.2 cd·s·m−2 and 12.3 ± 1.90 cd·s·m−2 in the NDE, that is an increase of 0.43 and 0.57 log unit (P < 0.0001), respectively. Increasing background luminance by 0.50 log units (80 cd·m−2, N = 4) resulted in implicit time normalization but not V
max amplitude. Rod V
max was decreased by 7% in NDE (P < 0.05) and sensitivity reduced by 0.40 log units (P < 0.0001), but our data suggest that the luminance may have not been sufficient to reach V
max in all participants in the NDE and that the sensitivity change may have been due to an inadequate inter-stimulus interval.
For the photopic ERG, increasing flash luminance is not sufficient to compensate for the smaller pupil size, whereas for the
scotopic ERG, more data are needed to establish proper inter-stimulus interval to perform recordings in a non-pharmacologically
dilated. 相似文献
68.
Risk factors associated with intracranial hemorrhage in adults with immune thrombocytopenia: A study of 27 cases
下载免费PDF全文
![点击此处可从《American journal of hematology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sara Melboucy‐Belkhir Mehdi Khellaf Alexandre Augier Marouane Boubaya Vincent Levy Guillaume Le Guenno Louis Terriou Bertrand Lioger Mikaël Ebbo Anne‐Sophie Morin Marie‐Paule Chauveheid Marc Michel Farid Belkhir Frédégonde About Christian Rose Guillaume Moulis Arsene Mekinian Jérôme Stirnemann Thomas Papo Stéphane Cheze Eric Rosenthal Jean‐François Viallard Nicolas Schleinitz Lionel Galicier Daniel Adoue Olivier Lambotte Mohamed Hamidou Bertrand Godeau Olivier Fain 《American journal of hematology》2016,91(12):E499-E501
69.
70.
Posterior reversible encephalopathy syndrome as a revealing manifestation of Guillain-Barré syndrome
We report a patient with a Guillain-Barré syndrome (GBS) revealed by a posterior reversible encephalopathy syndrome (PRES). The PRES is typically associated with bilateral parieto-occipital T2 and FLAIR hyperintense MRI lesions and observed in various etiologic conditions leading to acute arterial hypertension. PRES results from a breakdown of the circulatory autoregulation, many in the posterior cerebral territories. GBS can be considered as an independent risk factor of PRES, due to acute dysautonomia and pain with consecutive arterial hypertension, as well as to cytokine production changing capillary permability. Such patients with PRES-revealed GBS may be treated with intravenous immunoglobulin therapy only after exclusion of any ischemic or hemorrhagic cerebral complications, and after control of the blood pressure and of the encephalopathic signs and symptoms. 相似文献