全文获取类型
收费全文 | 57798篇 |
免费 | 3977篇 |
国内免费 | 224篇 |
专业分类
耳鼻咽喉 | 683篇 |
儿科学 | 1472篇 |
妇产科学 | 1081篇 |
基础医学 | 7245篇 |
口腔科学 | 949篇 |
临床医学 | 5594篇 |
内科学 | 11847篇 |
皮肤病学 | 715篇 |
神经病学 | 5554篇 |
特种医学 | 1942篇 |
外国民族医学 | 4篇 |
外科学 | 9780篇 |
综合类 | 814篇 |
现状与发展 | 1篇 |
一般理论 | 69篇 |
预防医学 | 5092篇 |
眼科学 | 1180篇 |
药学 | 3554篇 |
中国医学 | 63篇 |
肿瘤学 | 4360篇 |
出版年
2023年 | 220篇 |
2022年 | 422篇 |
2021年 | 995篇 |
2020年 | 557篇 |
2019年 | 948篇 |
2018年 | 1156篇 |
2017年 | 795篇 |
2016年 | 894篇 |
2015年 | 993篇 |
2014年 | 1644篇 |
2013年 | 2435篇 |
2012年 | 3579篇 |
2011年 | 3883篇 |
2010年 | 2189篇 |
2009年 | 2016篇 |
2008年 | 3507篇 |
2007年 | 3681篇 |
2006年 | 3658篇 |
2005年 | 3751篇 |
2004年 | 3678篇 |
2003年 | 3359篇 |
2002年 | 3291篇 |
2001年 | 472篇 |
2000年 | 358篇 |
1999年 | 566篇 |
1998年 | 748篇 |
1997年 | 635篇 |
1996年 | 571篇 |
1995年 | 538篇 |
1994年 | 482篇 |
1993年 | 439篇 |
1992年 | 359篇 |
1991年 | 365篇 |
1990年 | 300篇 |
1989年 | 302篇 |
1988年 | 288篇 |
1987年 | 272篇 |
1986年 | 257篇 |
1985年 | 311篇 |
1984年 | 474篇 |
1983年 | 401篇 |
1982年 | 525篇 |
1981年 | 511篇 |
1980年 | 495篇 |
1979年 | 250篇 |
1978年 | 291篇 |
1977年 | 284篇 |
1976年 | 221篇 |
1975年 | 218篇 |
1974年 | 235篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
82.
83.
84.
Charles A Lascano Samuel Szomstein Natan Zundel Raul J Rosenthal 《Surgery for obesity and related diseases》2005,1(4):443-446
The association between weight and blood pressure is well established, especially the paradigm of obesity-related hypertension. The relationship between diffuse autonomic dysfunction and orthostatic hypotension in patients with long-term diabetes mellitus is also well known. We report on a 57-year-old morbidly obese male with a long medical history of hypertension, myocardial infarction, type 2 diabetes mellitus, and hypothyroidism. After a loss of 147 pounds (representing a percent excess weight loss of 76%) within 6 months after gastric bypass surgery, the patient developed worsening orthostatic hypotension and near-syncopal episodes requiring medication. The subsequent diagnosis and treatment, as well as a literature review, are presented. 相似文献
85.
86.
87.
Mohamed Eid Fawzy Mohamed Shoukri Walid Hassan Vijayaraghavan Nambiar Miltiadis Stefadouros Charles C Canver 《Catheterization and cardiovascular interventions》2007,69(1):40-46
BACKGROUND: The effect of mitral valve morphology (MVM) on the long-term results of mitral balloon valvuloplasty (MBV) is not well established. The aim of the study was to evaluate the impact of MVM on long-term outcome of MBV. METHODS: Five hundred and eighteen consecutive patients (mean age, 31+/-11 years) who underwent successful MBV were followed up for 0.5-16.5 (mean, 6+/-4.5) years. Patients were divided into two groups according to their mitral echo score (MES) before MBV: group A (n=340; MES8). RESULTS: We report the immediate and long-term clinical and echocardiographic results of the above-mentioned 518 consecutive patients. The mitral valve area was significantly larger in group A than in group B, both immediately after MBV (2.0+/-0.3 vs. 1.82+/-0.3 cm2, respectively; P<0.0001) and also at the last follow-up (1.8+/-0.33 vs. 1.5+/-0.33 cm2, respectively; P<0.0001). Restenosis occurred in 38/340 (11%) in group A vs. 73/178 (41%) in group B (P<0.0001). Actuarial freedom from restenosis at 5, 10, 15 years were 92+/-2%, 85+/-3%, 65+/-6% for group A vs. 72+/-4%, 44+/-5%, 9+/-6% for group B (P<0.001). Event-free survival rates at 5, 10, 15 years for group A were 93+/-1%, 88+/-2%, 66+/-6% vs. 82+/-3%, 59+/-6%, 8+/-7% for group B (P<0.0001). Stepwise Cox multivariate regression analysis identified MES, preprocedure functional class, and postprocedure mitral valve area相似文献
88.
89.
90.
Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2 expression in tumors. 总被引:1,自引:0,他引:1
Anna Orlova Fredrik Y Nilsson Maria Wikman Charles Widstr?m Stefan St?hl J?rgen Carlsson Vladimir Tolmachev 《Journal of nuclear medicine》2006,47(3):512-519
In vivo diagnosis with cancer-specific targeting agents that have optimal characteristics for imaging is an important development in treatment planning for cancer patients. Overexpression of the HER2 antigen is high in several types of carcinomas and has predictive and prognostic value, especially for breast cancer. A new type of targeting agent, the Affibody molecule, was described recently. An Affibody dimer, His6-(ZHER2:4)2 (15.4 kDa), binds to HER2 with an affinity of 3 nmol/L and might be used for the imaging of HER2 expression. The use of 99mTc might improve the availability of the labeled conjugate, and Tc(I)-carbonyl chemistry enables the site-specific labeling of the histidine tag on the Affibody molecule. The goals of the present study were to prepare 99mTc-labeled His6-(ZHER2:4)2 and to evaluate its targeting properties compared with the targeting properties of 125I-4-iodobenzoate-His6-(ZHER2:4)2 [125I-His6-(ZHER2:4)2]. METHODS: The labeling of His6-(ZHER2:4)2 with 99mTc was performed with an IsoLink kit. The specificity of 99mTc-His6-(ZHER2:4)2 binding to HER2 was evaluated in vitro with SK-OV-3 ovarian carcinoma cells. The comparative biodistributions of 99mTc-His6-(ZHER2:4)2 and 125I-His6-(ZHER2:4)2 in tumor-bearing BALB/c nu/nu mice were determined. RESULTS: The labeling yield for 99mTc-His6-(ZHER2:4)2 was approximately 60% (50 degrees C), and the radiochemical purity was greater than 97%. The conjugate was stable during storage and under histidine and cysteine challenges and demonstrated receptor-specific binding. The biodistribution study demonstrated tumor-specific uptake levels (percentage injected activity per gram of tissue [%IA/g]) of 2.6 %IA/g for 99mTc-His6-(ZHER2:4)2 and 2.3 %IA/g for 125I-His6-(ZHER2:4)2 at 4 h after injection. Both conjugates provided clear imaging of SK-OV-3 xenografts at 6 h after injection. The tumor-to-nontumor ratios were much more favorable for the radioiodinated Affibody. CONCLUSION: The use of Tc(I)-carbonyl chemistry enabled us to prepare a stable, site-specifically labeled 99mTc-His6-(ZHER2:4)2 conjugate that was able to bind to HER2-expressing cells in vitro and in vivo. The indirectly radioiodinated conjugate provided better tumor-to-liver ratios. The labeling of Affibody molecules with 99mTc should be investigated further. 相似文献