全文获取类型
收费全文 | 242636篇 |
免费 | 38350篇 |
国内免费 | 3624篇 |
专业分类
耳鼻咽喉 | 6361篇 |
儿科学 | 7037篇 |
妇产科学 | 4243篇 |
基础医学 | 17852篇 |
口腔科学 | 3460篇 |
临床医学 | 35465篇 |
内科学 | 64894篇 |
皮肤病学 | 10062篇 |
神经病学 | 21051篇 |
特种医学 | 10570篇 |
外国民族医学 | 7篇 |
外科学 | 52812篇 |
综合类 | 2428篇 |
现状与发展 | 74篇 |
一般理论 | 53篇 |
预防医学 | 11928篇 |
眼科学 | 6222篇 |
药学 | 9423篇 |
5篇 | |
中国医学 | 1354篇 |
肿瘤学 | 19309篇 |
出版年
2024年 | 556篇 |
2023年 | 5282篇 |
2022年 | 2746篇 |
2021年 | 6286篇 |
2020年 | 7682篇 |
2019年 | 4377篇 |
2018年 | 10033篇 |
2017年 | 9363篇 |
2016年 | 10999篇 |
2015年 | 12035篇 |
2014年 | 19843篇 |
2013年 | 20674篇 |
2012年 | 13454篇 |
2011年 | 13045篇 |
2010年 | 14569篇 |
2009年 | 17775篇 |
2008年 | 11245篇 |
2007年 | 9274篇 |
2006年 | 11201篇 |
2005年 | 8180篇 |
2004年 | 6811篇 |
2003年 | 5370篇 |
2002年 | 4982篇 |
2001年 | 6335篇 |
2000年 | 5400篇 |
1999年 | 5114篇 |
1998年 | 4398篇 |
1997年 | 4016篇 |
1996年 | 3830篇 |
1995年 | 3615篇 |
1994年 | 2298篇 |
1993年 | 1906篇 |
1992年 | 2195篇 |
1991年 | 2188篇 |
1990年 | 1777篇 |
1989年 | 1843篇 |
1988年 | 1621篇 |
1987年 | 1480篇 |
1986年 | 1384篇 |
1985年 | 1157篇 |
1984年 | 866篇 |
1983年 | 782篇 |
1982年 | 665篇 |
1981年 | 545篇 |
1980年 | 490篇 |
1979年 | 531篇 |
1978年 | 486篇 |
1977年 | 509篇 |
1975年 | 407篇 |
1972年 | 421篇 |
排序方式: 共有10000条查询结果,搜索用时 484 毫秒
21.
22.
23.
Moderate sedatives have been increasingly used to improve patient comfort during flexible bronchoscopy (FB). However, routine use of moderate sedation during FB is controversial because its efficacy and safety are not well established.This study aims to evaluate the efficacy and safety of moderate sedation during FB.A search was made of Medline, EMBASE, and the Cochrane Library to May 2014.Randomized controlled trials (RCTs) and quasi-RCTs were included.The main analysis was designed to examine the efficacy of moderate sedation during FB in sedation than no-sedation.The willingness to repeat FB was significantly more in sedation than no-sedation (odds ratio [OR] 2.30; 95% confidence interval [CI] 1.11–4.73; P = 0.02; I2 = 22.5). The duration of FB was shorter in sedation group than no-sedation group (standardized mean difference [SMD] −0.21; 95% CI −0.38 to −0.03; P = 0.02; I2 = 78.3%). Event of hypoxia was not significantly different between sedation and no-sedation groups (OR 0.86; 95% CI 0.42–1.73; P = 0.67; I2 = 0%). The SpO2 during procedure was not different between sedation and no-sedation groups (SMD −0.14; 95% CI −0.37 to 0.08; P = 0.21; I2 = 49.9%). However, in subgroup analysis without supplemental oxygen, the SpO2 was significantly lower in sedation than no-sedation group (SMD −0.45; 95% CI −0.78 to −0.11; P = 0.01; I2 = 0.0%).According to this meta-analysis, moderate sedation in FB would be useful in patients who will require repeated bronchoscopies as well as safe in respiratory depression. To our knowledge, although the various sedative drugs are already used in the real field, this analysis was the first attempt to quantify objective results. We anticipate more definite and studies designed to elucidate standardized outcomes for moderate sedation in FB. 相似文献
24.
25.
Whitney S. Brandt Wanpu Yan Jian Zhou Kay See Tan Joseph Montecalvo Bernard J. Park Prasad S. Adusumilli James Huang Matthew J. Bott Valerie W. Rusch Daniela Molena William D. Travis Mark G. Kris Jamie E. Chaft David R. Jones 《The Journal of thoracic and cardiovascular surgery》2019,157(2):743-753.e3
Objective
Comparative survival between neoadjuvant chemotherapy and adjuvant chemotherapy for patients with cT2-4N0-1M0 non–small cell lung cancer has not been extensively studied.Methods
Patients with cT2-4N0-1M0 non–small cell lung cancer who received platinum-based chemotherapy were retrospectively identified. Exclusion criteria included stage IV disease, induction radiotherapy, and targeted therapy. The primary end point was disease-free survival. Secondary end points were overall survival, chemotherapy tolerance, and ability of Response Evaluation Criteria In Solid Tumors response to predict survival. Survival was estimated using the Kaplan–Meier method, compared using the log-rank test and Cox proportional hazards models, and stratified using matched pairs after propensity score matching.Results
In total, 330 patients met the inclusion criteria (n = 92/group after propensity-score matching; median follow-up, 42 months). Five-year disease-free survival was 49% (95% confidence interval, 39-61) for neoadjuvant chemotherapy versus 48% (95% confidence interval, 38-61) for adjuvant chemotherapy (P = .70). On multivariable analysis, disease-free survival was not associated with neoadjuvant chemotherapy or adjuvant chemotherapy (hazard ratio, 1.1; 95% confidence interval, 0.64-1.90; P = .737), nor was overall survival (hazard ratio, 1.21; 95% confidence interval, 0.63-2.30; P = .572). The neoadjuvant chemotherapy group was more likely to receive full doses and cycles of chemotherapy (P = .014/0.005) and had fewer grade 3 or greater toxicities (P = .001). Response Evaluation Criteria In Solid Tumors response to neoadjuvant chemotherapy was associated with disease-free survival (P = .035); 15% of patients receiving neoadjuvant chemotherapy (14/92) had a major pathologic response.Conclusions
Timing of chemotherapy, before or after surgery, is not associated with an improvement in overall or disease-free survival among patients with cT2-4N0-1M0 non–small cell lung cancer who undergo complete surgical resection. 相似文献26.
27.
28.
Hyun Jong Choi Jong Ho Moon Yun Nah Lee Hyun Su Kim Ji Su Ha Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park 《Digestive endoscopy》2015,27(7):772-775
Direct peroral cholangioscopy (POC) using an ultra‐slim upper endoscope is one modality of POC for intraductal endoscopic evaluation and treatment of the bile duct. Choledochoduodenostomy (CDS) is one modality of biliary bypass surgery that provides a new route to the bile duct. We carried out direct POC using an ultra‐slim upper endoscope without the use of accessories in 10 patients (four sump syndromes, three bile duct strictures and three intrahepatic duct stones) previously undergoing surgical CDS. Direct POC was successful in all patients. The use of an intraductal balloon catheter was required in one patient for advancement of the endoscope into the bile duct. Distal bile ducts with sump syndromes were cleared using baskets and water irrigation under direct POC. Cholangiocarcinoma was diagnosed in one patient with hilar bile duct stricture after cholangioscopic evaluation and a targeting forceps biopsy under direct POC. Intrahepatic duct stones were successfully extracted after intraductal fragmentation under direct POC. Oozing bleeding occurred during intraductal lithotripsy but stopped spontaneously. Direct POC using an ultra‐slim upper endoscope without the assistance of accessories can easily be carried out in patients undergoing CDS. 相似文献
29.
30.
Interprofessional collaboration and communication in nursing homes: a qualitative exploration of problems in medical care for nursing home residents – study protocol
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)