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101.
血清Ⅳ型胶原测定在肾移植中的意义 总被引:2,自引:2,他引:0
目的:探讨血清Ⅳ型胶原(Ⅳ-C)动态变化在肾移植术后监测中的意义。方法:检测61例肾移植患者血清Ⅳ-C浓度,观察不同病情状况时血清Ⅳ-C浓度的改变。结果显示:肾移植术前及术后动态测定血清Ⅳ-C浓度有助于早期诊断和鉴别诊断急性排斥反应(AR)、急性肾小管坏死(ATN)和感染,可作为肾移植监测的一个辅助指标。 相似文献
102.
DJ SINGH 《Medical Journal Armed Forces India》1996,52(4):239-241
Stress fractures amongst military recruits are limited to the lower extremities; yet involvement of the shaft of the femur is unusual. Seven such cases in a series of 352 stress fractures are presented. The importance of early recognition and management is emphasized with a view to prevent bony disruption in an otherwise easily treatable condition.KEY WORDS: Fractures stress, Femoral fractures 相似文献
103.
Preliminary result of mixed bacterial vaccine as adjuvant treatment of hepatocellular carcinoma. 总被引:2,自引:0,他引:2
Z Y Tang H Y Zhou G Zhao L M Chai M Zhou J Z Lu K D Liu H F Havas H C Nauts 《Medical oncology and tumor pharmacotherapy》1991,8(1):23-28
Mixed bacterial vaccine (MBV) was employed in the multi-modality treatment of hepatocellular carcinoma (HCC) during 1985-1988. Thirty eight patients undergoing palliative resection and cisplatin therapy (Series 1) and 48 patients with unresectable HCC who received hepatic artery ligation + intraarterial cisplatin infusion + radiotherapy (Series 2) were randomized to receive MBV or not. In series 1, the 1- and 2-year survival rates of MBV group and control were 75% vs 58% (P = 0.19) and 45% vs 39% (P = 0.23). In series 2, the 1-, 2- and 3-year survival rates were 59%, 41% and 41% for MBV group and 39%, 25% and 20% for the control, respectively (P1 = 0.07, P2 = 0.09, P3 = 0.07). In addition, MBV improved the "second look" resection rate to 40% as compared to 17% in the control (P greater than 0.05). MBV could also prevent such immunosuppression as decrease of macrophage activity caused by radiotherapy. We consider MBV a potential nonspecific immunostimulant in the multimodality treatment of HCC. 相似文献
104.
105.
头孢硫脒等6种抗菌药物对革兰氏阳性球菌体外抗菌活性研究 总被引:1,自引:0,他引:1
目的 对比研究头孢硫脒(CTM)、头孢唑林(CEZ)、头孢映辛(CXM)、头孢曲松(CRO)、苯唑西林(MPIPC)、万古霉素(VCM)对99株临床分离革兰氏阳性球菌的抗菌活性。方法采用琼脂平板稀释法测定最低抑菌浓度(MIC)。结果 CTM对32株金黄色葡萄球菌的MIC50、MIC90均为0.5mg/L,低于CRO,CTM对29株表皮葡萄球菌的MIC50、MIC90分别为0.125和8mg/L,是CRO的l/16,对9株甲氧西林耐药的葡萄球菌(MRS)的范围与CXM相近;CTM对粪肠球菌的抗菌活性与万古霉家相仿,强于CEZ、CXM、CRO、LGIPC。结论头孢硫腺对葡萄球菌和粪肠球菌具有很强的体外抗菌活性。 相似文献
106.
The purpose of this study was to determine whether micturition reflexes are altered in aged rats. Voiding frequencies and
awake cystometrograms (CMGs) were measured in young (3–5 months old) and aged (24 months) F344 male rats. Bladder contractions
induced by subcutaneous apomorphine and intravesical capsaicin stimulation were measured using awake CMGs. Urodynamic parameters
were compared. Aged rats voided less frequently (4.1 vs 6.9 times/18 h, P=0.006), with a higher volume per void (1.1 vs 0.7 ml, P=0.02) and had a higher micturitional threshold pressure (8.7 vs 4.6 mmHg, P=0.0001) than the young rats. Apomorphine induced a higher frequency of bladder contractions in aged animals compared to young
animals (5.5 vs 3.1 contractions/min, P=0.03). Intravesical capsaicin caused a lower pressure bladder response in the aged rats (38.5 vs 70.6 mmHg, P=0.01) compared to the young rats. Bladder afferents and central micturition pathways may be altered in aged rats. Impaired
bladder contractility in the elderly may be exacerbated by reduced sensory input, whereas the propensity for detrusor instability
could result from altered central processing. This study demonstrated the utility of the F344 animal model to study micturitional
changes resulting from aging.
Received: 14 April 2000 / Accepted: 4 July 2000 相似文献
107.
MA Ebert J Blight S Price A Haworth C Hamilton D Cornes DJ Joseph 《Journal of Medical Imaging and Radiation Oncology》2004,48(3):347-352
Digital data from 3‐D treatment planning computers is generally used for patient planning and then never considered again. However, such data contains enormous quantities of information regarding patient geometries, tissue outlining, treatment approaches and dose distributions. Were such data accessible from planning systems from multiple manufacturers, there would be substantial opportunities for undertaking quality assurance of radiotherapy clinical trials, prospective assessment of trial outcomes and basic treatment planning research and development. The technicalities of data exchange between planning systems are outlined, and previous attempts at producing systems capable of viewing and/or manipulating imaging and radiotherapy digital data reviewed. Development of a software system for enhancing the quality of Australasian clinical trials is proposed. 相似文献
108.
OBJECTIVES: A highly effective treatment for interstitial cystitis (IC) remains elusive. We determined whether sacral third nerve root (S3) percutaneous neurostimulation (PNS) might be effective in relieving symptoms of IC, as well as in normalizing urinary factors that are specifically altered in IC. METHODS: Six consecutive patients with symptoms and cystoscopic findings compatible with IC underwent 5 days of continuous S3 neurostimulation by way of leads placed percutaneously into the S3 foramen. Patients filled out voiding frequency diaries and pain and urgency questionnaires before PNS and at the end of PNS when the leads were removed. Urine specimens were collected at these two time points and measured for heparin-binding epidermal growth factor-like growth factor (HB-EGF) by enzyme-linked immunosorbent assay and for antiproliferative factor (APF) activity by (3)H-thymidine uptake by normal human bladder urothelial cells. RESULTS: S3 PNS significantly improved all measured parameters toward normal values. Voiding frequency decreased twofold from 23.1 +/- 4.6 to 10.6 +/- 4.0 voids daily during PNS (P = 0.0001). Pelvic pain on a scale of 1 to 10 decreased from 7.0 +/- 1.6 to 2.3 +/- 3.2 (P = 0.05). Urinary urgency on a scale of 1 to 10 decreased from 6.0 +/- 2.2 to 1.8 +/- 1.7 (P = 0. 02). Urinary HB-EGF concentration increased sevenfold from 1.5 +/- 2. 1 to 11.0 +/- 1.7 ng/mL (P <0.0001), and urinary APF activity decreased from -76.1% +/- 31% to -4.5% +/- 8.8% (P = 0.005). CONCLUSIONS: S3 PNS significantly decreased symptoms and normalized urinary HB-EGF and APF activity in patients with IC. These results suggest that permanent S3 PNS may be beneficial in treating IC. 相似文献
109.
S Bydder NA Spry DRH Christie D Roos BH Burmeister H Krawitz S Davis DJ Joseph M Poulsen M Berry 《Journal of Medical Imaging and Radiation Oncology》2003,47(3):284-288
The purpose of this study was to prospectively examine the effectiveness and tolerability of a simple radiotherapy technique for the palliation of symptomatic liver metastases. Twenty‐eight patients with symptomatic liver metastases were enrolled from seven centres, and received targeted (partial or whole) liver irradiation consisting of 10 Gy in two fractions over 2 days. Symptoms at baseline were hepatic pain (27 patients), abdominal distension (19), night sweats (12), nausea (18) and vomiting (eight). Twenty‐two patients (76%) had failed previous treatment with chemotherapy, hormonal therapy and/or high‐dose steroids. Symptoms and potential toxicities were prospectively assessed at the time of treatment, then 2, 6 and 10 weeks later. Individual symptom response rates were 53?66% at 2 weeks. Partial or complete global symptomatic responses were noted in 15 patients (54%) overall. The treatment was well tolerated with two patients (7%) experiencing grade 3 toxicity (one vomiting and one diarrhoea); however, four patients reported temporary worsening of pain shortly after treatment. This simple and well‐tolerated treatment achieves useful palliation. 相似文献
110.
Glenn Arendts Alvaro Manovel Alan Chai 《Journal of Medical Imaging and Radiation Oncology》2003,47(4):368-374
The aims of the present study were to determine the rate of misinterpretation of non‐contrast cranial CT scans by emergency specialists and trainees compared with specialist radiologists, and the proportion of misinterpretations that is consequential. A 12‐month prospective blinded cohort study was performed. One‐hundred and ninety of 1282 scans (14.8%) were misinterpreted, and 78 of these (41.1%) were of potential or actual consequence. We conclude that the performance of senior emergency department staff in non‐contrast cranial CT interpretation is no better than moderately good, and a large proportion of misinterpretations are of potential or actual clinical consequence. 相似文献