Tuberculous granuloma in haemangiomatous nasal polyp

Tuberculosis of upper respiratory tract is quite infrequent especially the nasal involvement. Isolated cases have been reported by certain authors. A ease of nasal tubercolosis is being presented for its rare site and its association with haemangioma.     

Performing Testicular or Epididymal Sperm Retrieval Prior to the Injection of hCG

Purpose: Our purpose was to determine the feasibility and efficacy of performing testicular or epididymal sperm retrieval prior to the injection of human chorionic gonadotropin (hCG). Methods: This report deals with 87 sperm-positive percutaneous epididymal sperm aspiration (PESA), percutaneous testicular sperm aspiration (PTSA), or testicular sperm extraction (TESE) cycles. All sperm retrieval procedures were performed prior to administration of hCG to the women. Retrieved spermatozoa were cultured in vitro in simple medium for approximately 40 hr prior to intracyto-plasmic sperm injection. Results: In all but one cycle in which TESE was performed for nonobstructive azoospermia, motile sperm were available for ICSI. The overall fertilization rate was 53%. Pregnancy rate per transfer and implantation rate per embryo were 41.2 and 15.7%, respectively. Conclusions: Satisfactory fertilization and pregnancy rates can be achieved when PESA, PTSA, or TESE is performed prior to the injection of hCG followed by in vitro culture of spermatozoa approximately 40 hr before ICSI. Scheduling of testicular or epididymal sperm retrieval cases in this way appears to ease the workload on laboratory and operating room personnel. Furthermore, withholding hCG when sperm is absent may obviate the unnecessary risk of ovarian hyperstimulation when spermatozoa cannot be retrieved.     

Complete Removal of Colloid Cyst via CT-Guided Stereotactic Biportal Neuroendoscopy

Four patients harbouring a colloid cyst of the 3rd ventricle were operated on endoscopically. With the "classical" monoportal technique, through a precoronal burr hole only partial removal could be achieved in the first case. As the crucial point of the procedure is the safe dissection of the cyst from the thela chorioidea and from the internal cerebral veins, adequate control of the posterior rim of the foramen of Monro and the roof of the 3rd ventricle is mandatory. Accordingly in other three cases a CT-guided biportal endoscopic technique was applied, which permitted radical removal of the entire cyst with maximum safety. CT-guidance is essential for optimal planning after careful study of the individual anatomy. In this way the rigid scopes are moved exclusively along their own axes throughout the procedure, the resulting brain damage thereby being minimal. With regard to all circumstances of the procedure, the use of flexible endoscopes appears to be inappropriate and biportal endoscopy offers itself as the method of choice.     

Protective effects of thymoquinone and methotrexate on the renal injury in collagen-induced arthritis

The goal of this investigation was to study the protective effects of thymoquinone (TQ) and methotrexate (MTX) on collagen-induced arthritis (CIA) in rats. On day 0 under ether anesthesia, the experimental groups were immunized with 0.5 mg native chick collagen II (CII) solubilized in 0.1 M acetic acid and emulsified in Freund's incomplete adjuvant. Control rats were gavaged with vehicle, whereas CII was administered intradermally. In addition, arthritis treated with TQ group received TQ (10 mg kg(-1) bw by gavage once a week for 3 weeks starting on day 0); and arthritis treated with MTX group received MTX (MTX was suspended in corn oil and administered by gavage at 1 mg kg (-1) bw once a week for 3 weeks starting on day 0). A significant decrease in the incidence and severity of arthritis by clinical and radiographic assessments was found in recipients of therapy, compared with that of controls. The MTX treatment significantly (P<0.01) decreased the elevated serum NO, urea and creatinine in arthritic rats. Likewise, TQ treatment was also able to reduce significantly (P<0.05) serum NO, urea and creatinine levels, but to lesser extent than MTX. The histopathologic abnormalities are consistent with the hydropic epithelial cell degenerations and moderate tubular dilatation in the some proximal and distal tubules. The severity of the degenerative changes in most of the shrunken glomerules and vascular congestion were also observed in arthritic animals. Preventive treatment of TQ and especially MTX significantly inhibited kidney dysfunction and this histopathologic alterations. These studies indicate that TQ can be used similar to MTX as a safe and effective therapy for CIA and may be useful in the treatment of rheumatoid arthritis.     

Malignant transformation in mature cystic teratoma of the ovary: report of five cases and review of the literature

The incidence of malignant transformation in mature cystic teratoma (MCT) of the ovary is less than 2% as reported in gynaecological and pathological literature. Here we present a series of five patients, who developed malignant transformation in MCT of the ovary, over a 6-year period (1999–2004). The morphological and clinico-pathological features of malignant transformation in MCT of the ovary are discussed.     

Die Lipomatose der Bauchspeicheldrüse und deren Bezug zur allgemeinen Fettsucht

Zusammenfassung Die Lipomatose der Bauchspeicheldrüse stellt einen Zustand dar, bei dem die Drüsensubstanz von Fettgewebe in größere und kleinere Teile getrennt wird. Die Bestimmung des quantitativen Verhältnisses zwischen dem Fettgewebe und dem Parenchym derartiger Bauchspeicheldrüsen schien nur auf dem Wege der chemischen Untersuchung möglich.Über die Menge des Parenchyms des Pankreas gibt der Parenchymindex Aufschluß. Dieser bedeutet den auf die Drüsensubstanz fallenden Teil des Trockenrückstandes in der Gewichtseinheit ausgedrückt. Den Parenchymindex erhält man, wenn man die extrahierte Fettmenge vom Gesamttrockenrückstand abzieht und das erhaltene Ergebnis dem Trockenrückstand des Fettes gemäß berichtigt. Der Parenchym-index ist bei Lipomatose des Pankreas meist bedeutend geringer als bei normalem Pankreas. Hieraus darf man schließen, daß die Lipomatose des Pankreas entweder dadurch zustande kommt, daß Teile der Drüsensubstanz, die durch Nekrose zugrunde gegangen waren, durch Fettgewebe ersetzt werden, oder dadurch, daß im Zwischen-bindegewebe Fett abgelagert wird, welches den Untergang des Drüsenparenchyms bewirkt.Es erscheint als nachgewiesen, daß die Mehrleistung der Langerhansschen Inseln die sog. insuläre Fettsucht hervorruft. Fettsucht wird auch in Fällen von Lipomatose des Pankreas beobachtet, bei denen nicht nur keine Mehr-, sondern eine Minderleistung der Inseln anzunehmen ist. Es scheint wahrscheinlich, daß von seiten des Pankreas außer dem Inselapparat auch noch die Funktion der Parenchymzellen einen Einfluß auf den Fettstoffwechsel ausübt, da auch die Verminderung der Parenchymmenge bei der Entstehung der Fettsucht eine Rolle spielen kann.Mit 6 Textabbildungen.