全文获取类型
收费全文 | 9062篇 |
免费 | 569篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 55篇 |
儿科学 | 211篇 |
妇产科学 | 111篇 |
基础医学 | 1281篇 |
口腔科学 | 30篇 |
临床医学 | 859篇 |
内科学 | 2324篇 |
皮肤病学 | 120篇 |
神经病学 | 755篇 |
特种医学 | 352篇 |
外科学 | 1665篇 |
综合类 | 23篇 |
一般理论 | 2篇 |
预防医学 | 368篇 |
眼科学 | 75篇 |
药学 | 585篇 |
中国医学 | 22篇 |
肿瘤学 | 837篇 |
出版年
2023年 | 45篇 |
2022年 | 75篇 |
2021年 | 231篇 |
2020年 | 122篇 |
2019年 | 242篇 |
2018年 | 245篇 |
2017年 | 195篇 |
2016年 | 199篇 |
2015年 | 266篇 |
2014年 | 329篇 |
2013年 | 422篇 |
2012年 | 705篇 |
2011年 | 727篇 |
2010年 | 412篇 |
2009年 | 388篇 |
2008年 | 590篇 |
2007年 | 623篇 |
2006年 | 589篇 |
2005年 | 662篇 |
2004年 | 566篇 |
2003年 | 539篇 |
2002年 | 560篇 |
2001年 | 72篇 |
2000年 | 55篇 |
1999年 | 94篇 |
1998年 | 119篇 |
1997年 | 73篇 |
1996年 | 69篇 |
1995年 | 48篇 |
1994年 | 60篇 |
1993年 | 52篇 |
1992年 | 21篇 |
1991年 | 25篇 |
1990年 | 32篇 |
1989年 | 17篇 |
1988年 | 20篇 |
1987年 | 20篇 |
1986年 | 13篇 |
1985年 | 13篇 |
1984年 | 14篇 |
1983年 | 13篇 |
1982年 | 12篇 |
1981年 | 16篇 |
1980年 | 11篇 |
1979年 | 12篇 |
1976年 | 9篇 |
1975年 | 6篇 |
1973年 | 7篇 |
1972年 | 7篇 |
1971年 | 5篇 |
排序方式: 共有9675条查询结果,搜索用时 359 毫秒
111.
Thierry Bautrant Michel Grino Corinne Peloso Frédéric Schiettecatte Magali Planelles Charles Oliver Caroline Franqui 《Journal of the American Medical Directors Association》2019,20(3):377-381
Objectives
To determine whether environmental rearrangements of the long-term care nursing home can affect disruptive behavioral and psychological symptoms of dementia (BPSD) in residents with dementia.Design
Prospective 6-month study.Setting
The study was conducted before (phase 1) and after (phase 2) environmental rearrangements [skylike ceiling tiles in part of the shared premises, progressive decrease of the illuminance at night together with soothing streaming music, reinforcement of the illuminance during the day, walls painted in light beige, oversized clocks in corridors, and night team clothes color (dark blue) different from that of the day team (sky blue)].Participants
All of the patients (n = 19) of the protected unit were included in the study. They were aged 65 years or older and had an estimated life expectancy above 3 months.Measures
Number and duration of disruptive BPSD were systematically collected and analyzed over 24 hours or during late hours (6:00-12:00 pm) during each 3-month period.Results
There was no significant change in the patients' dependency, risk of fall, cognitive or depression indexes, or treatment between phase 1 and 2. Agitation/aggression and screaming were observed mainly outside the late hours as opposed to wandering episodes that were noticed essentially within the late hours. The number of patients showing wandering was significantly lower over 24 hours during phase 2. The number of agitation/physical aggression, wandering, and screaming and the mean duration of wandering episodes were significantly (P = .039, .002, .025, and .026 respectively) decreased over 24 hours following environmental rearrangements. Similarly, a significant reduction in the number and mean duration of wandering was noticed during the late hours (P = .031 and .007, respectively).Conclusions
Our study demonstrates that BPSD prevalence can be reduced following plain environmental rearrangements aimed at improving spatial and temporal orientation. 相似文献112.
113.
114.
115.
116.
Martine Mazel William Jacot Klaus Pantel Kai Bartkowiak Delphine Topart Laure Cayrefourcq Delphine Rossille Thierry Maudelonde Thierry Fest Catherine Alix-Panabières 《Molecular oncology》2015,9(9):1773-1782
Immune checkpoint regulators such as PD‐L1 have become exciting new therapeutic targets leading to long lasting remissions in patients with advanced malignancies. However, in view of the remarkable costs and the toxicity profiles of these therapies, predictive biomarkers able to discriminate responders from non‐responders are urgently needed. In the present paper, we provide evidence that PD‐L1 is frequently expressed on metastatic cells circulating in the blood of hormone receptor‐positive, HER2‐negative breast cancer patients. We performed western blot, flow cytometry and immunocytochemical analyses to demonstrate the specificity of the PDL1 antibody used in our study and established immunoscores for PDL1 expression on single tumor cells. We then selected sixteen patients with circulating tumor cells (CTCs) using the CellSearch® system and found PD‐L1(+) CTCs in 11 patients (68.8%). The fraction of PD‐L1(+) CTCs varied from 0.2 to 100% in individual patients. This is the first report demonstrating the expression of PD‐L1 on CTCs. The established CTC/PD‐L1 assay can be used for liquid biopsy in future clinical trials for stratification and monitoring of cancer patients undergoing immune checkpoint blockade. 相似文献
117.
Maarten Bloemen Stefaan Vandendriessche Vincent Goovaerts Ward Brullot Maarten Vanbel Sophie Carron Nick Geukens Tatjana Parac-Vogt Thierry Verbiest 《Materials》2014,7(2):1155-1164
Rare earth atoms exhibit several interesting properties, for example, large magnetic moments and luminescence. Introducing these atoms into a different matrix can lead to a material that shows multiple interesting effects. Holmium atoms were incorporated into an iron oxide nanoparticle and the concentration of the dopant atom was changed in order to determine its influence on the host crystal. Its magnetic and magneto-optical properties were investigated by vibrating sample magnetometry and Faraday rotation measurements. The luminescent characteristics of the material, in solution and incorporated in a polymer thin film, were probed by fluorescence experiments. 相似文献
118.
119.
120.
Camille Lasserre Luc De Saint Martin Gaelle Cuzon Pierre Bogaerts Estelle Lamar Youri Glupczynski Thierry Naas Didier Tandé 《Journal of clinical microbiology》2015,53(7):2163-2171
The recognition of carbapenemase-producing Enterobacteriaceae (CPE) isolates is a major laboratory challenge, and their inappropriate or delayed detection may have negative impacts on patient management and on the implementation of infection control measures. We describe here a matrix-assisted laser desorption ionization−time of flight (MALDI-TOF)-based method to detect carbapenemase activity in Enterobacteriaceae. After a 20-min incubation of the isolate with 0.5 mg/ml imipenem at 37°C, supernatants were analyzed by MALDI-TOF in order to identify peaks corresponding to imipenem (300 Da) and an imipenem metabolite (254 Da). A total of 223 strains, 77 CPE (OXA-48 variants, KPC, NDM, VIM, IMI, IMP, and NMC-A) and 146 non-CPE (cephalosporinases, extended-spectrum β-lactamases [ESBLs], and porin defects), were tested and used to calculate a ratio of imipenem hydrolysis: mass spectrometry [MS] ratio = metabolite/(imipenem + metabolite). An MS ratio cutoff was statistically determined to classify strains as carbapenemase producers (MS ratio of ≥0.82). We validated this method first by testing 30 of our 223 isolates (15 CPE and 15 non-CPE) 10 times to calculate an intraclass correlation coefficient (ICC of 0.98), showing the excellent repeatability of the method. Second, 43 strains (25 CPE and 18 non-CPE) different from the 223 strains used to calculate the ratio cutoff were used as external controls and blind tested. They yielded sensitivity and specificity of 100%. The total cost per test is <0.10 U.S. dollars (USD). This easy-to-perform assay is time-saving, cost-efficient, and highly reliable and might be used in any routine laboratory, given the availability of mass spectrometry, to detect CPE. 相似文献