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排序方式: 共有878条查询结果,搜索用时 10 毫秒
61.
ANNA-MARIA WNUK-WOJNAR LESZEK GIEC JANUSZ DRZEWIECKI MARIA TRUSZ-GLUZA RZEJ DABROWSKI STANISAW PASYK 《Pacing and clinical electrophysiology : PACE》1990,13(12):2127-2132
WNUK-WOJNAR, A.M., ET AL.: Predictors of Ventricular Tachycardia Inducibility in Programmed Electrical Stimulation and Effectiveness of Serial Drug Testing: Polish Multicenter Study. In 100 patients with IHD and complex ventricular arrhythmias, programmed electrical stimulation was performed using up to three extrastimuli at sinus rhythm, and paced 100, 120, and 140 beats/min delivered from the RV apex, outflow tract or the LV with ventricular mapping to evaluate late potentials (LP) in 41 patients. Sustained monomorphic VT (SMVT) was provoked in 91% of 42 patients with a history of VT/VF, p < 0.001, all five patients had SMVT in 24-hour ECG, p < 0.005, and 91% of 21 patients with LV dyskinesis, p < 0.01. After depolarizations were found in 62% of 21 patients with a history of VT, in 58% of 31 patients with inducible VT, p < 0.01 and in five of six patients with LV dyskinesis. In patients with inducible VT, LP had a higher amplitude (105 ± 35 vs 60 ± 47 µV) and were more delayed (202 ± 96 vs 133 ± 75 msec) than in noninducible patients. In 17 patients, serial drug testing was performed after oral administration using mexilitene, disopyramide, chinidine, propafenone, sotalol, and amiodarone. If one drug was tested, the therapy efficacy was 25% if two drugs-60%, and if three drugs-75%. In eight patients, VT was inducible in all tests, but in only one of these patients chronic antiarrhythmic therapy was not effective. We conclude that the most important predictors of VT inducibility are a history of VT or 24-hour ECG, and LV dyskinesis. Serial drug testing is efficient only when many drugs are tested, but even if VT is inducible, it does not exclude the possibility of a good clinical outcome in chronic therapy. 相似文献
62.
American College of Cardiology Foundation;American Society of Interventional & Therapeutic Neuroradiology;Society for Cardiovascular Angiography Interventions;Society for Vascular Medicine Biology;Society of Interventional Radiology Bates ER Babb JD Casey DE Cates CU Duckwiler GR Feldman TE Gray WA Ouriel K Peterson ED Rosenfield K Rundback JH Safian RD Sloan MA White CJ 《Journal of the American College of Cardiology》2007,49(1):126-170
63.
Leandra JM Boonman-de Winter Frans H Rutten Maarten J Cramer Anho H Liem Marcel J Landman Henk F van Stel G Ardine de Wit Guy EHM Rutten Paulien AW van Hessen Arno W Hoes 《BMC public health》2009,9(1):479
Background
We hypothesize that the prevalence of unknown heart failure in diabetic patients aged 60 years and over is relatively high (15% or more) and that a cost-effective strategy can be developed to detect heart failure in these patients. The strategy is expected to include some signs and symptoms (such as dyspnoea, orthopnoea, pulmonary crepitations and laterally displaced apical beat), natriuretic peptide measurements (Amino-terminal B-type natriuretic peptide) and possibly electrocardiography. In a subset of patients straightforward echocardiography may show to be cost-effective. With information from our study the detection of previously unknown heart failure in diabetic patients could be improved and enable the physician to initiate beneficial morbidity and mortality reducing heart failure treatment more timely. 相似文献64.
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68.
David S. Cates B. Kent Houston Christine R. Vavak Michael H. Crawford Meredith Uttley 《Journal of behavioral medicine》1993,16(3):237-256
Hostility-related variables have been categorized as to kinds of emotions, attitudes, and behaviors. Relatively few studies have explored whether genetic factors contribute to individual differences in these variables. Moreover, the majority of this research has involved male subjects. The present study utilized the twin method to evaluate the influence of genetic factors on hostility-related emotions, namely, trait anger and irritability, hostility-related attitudes, namely cynical hostility and suspiciousness, and hostility-related behaviors, namely, physical, verbal, and indirect aggression in adult women. Responses on the measure of trait anger showed evidence of significant heritability. However, evidence for a genetic component to responses on the irritability scale was less clear. There was no support for the notion of a genetic component to the measure of suspiciousness, and the evidence of a genetic contribution for cynical hostility was not significant. It was expected that due to environmental influences for women, only certain forms of aggression would show genetic variance, namely, verbal and indirect as opposed to physical forms. The results were generally congruent with these expectations.This study was supported, in part, by a General Research Fund Award from the University of Kansas to B. Kent Houston and a Research Improvement Award from the University of Kansas to Michael H. Crawford. 相似文献
69.
Susanne M Rittig Maik Haentschel Katrin J Weimer Annkristin Heine Martin R Muller Wolfram Brugger Marius S Horger Olga Maksimovic Arnulf Stenzl Ingmar Hoerr Hans-Georg Rammensee Tobias AW Holderried Lothar Kanz Steve Pascolo Peter Brossart 《Molecular therapy》2011,19(5):990-999
The aim of this phase I/II nonrandomized trial was to assess feasibility, safety as well as immunological and clinical responses of a mRNA-based vaccination in patients with stage IV renal cell cancer using granulocyte-macrophage colony stimulating factor (GM-CSF) as adjuvant. Intradermal injections of in vitro transcribed naked mRNA, which was generated using plasmids coding for the tumor-associated antigens mucin 1(MUC1), carcinoembryonic (CEA), human epidermal growth factor receptor 2 (Her-2/neu), telomerase, survivin, and melanoma-associated antigen 1 (MAGE-A1) were performed in 30 enrolled patients. In the first 14 patients (cohort A) vaccinations were administered on days 0, 14, 28, and 42 (20 µg/antigen) while in the consecutive 16 patients (cohort B) an intensified protocol consisting of injections at days 0–3, 7–10, 28, and 42 (50 µg/antigen) was used. In both cohorts, after this induction period, vaccinations were repeated monthly until tumor progression analyzed by Response Evaluation Criteria In Solid Tumors criteria (RECIST). Vaccinations were well tolerated with no severe side effects and induced clinical responses [six stable diseases (SD) and one partial response in cohort A and nine SD in cohort B]. In cohort A, 35.7% survived 4 years (median survival 24 months) compared to 31.25% in cohort B (median survival 29 months). Induction of CD4+ and CD8+ T cell responses was shown for several tumor-associated antigens (TAA) using interferon-γ (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) and Cr-release assays. 相似文献
70.
Susanna L Cooke Jessica CM Pole Suet-Feung Chin Ian O Ellis Carlos Caldas Paul AW Edwards 《BMC cancer》2008,8(1):288