大丁草中抗菌活性成分的研究Ⅳ

从秋季采收的菊科植物大丁草Gerbera anandria(L.)Sch Bip.全草中共分出十三种成分。本文报道其中三个新化合物的结构鉴定.它们分别是3,8-dihydroxy-4-methoxy-coumarin(ⅪⅩ),3,8-dihydroxy-4-methoxy-2-oxo-2 H-1-benzopyran-5-carboxylic acid(ⅩⅦ),和5,8-dihydroxy-7-(4-hydroxy-5-methyl-coumarin-3-)-coumarin(ⅩⅪ)。     

Double aorto-enteric fistula]

Gastric metastases are rare, usually discovered at autopsy. The most frequent ones are breast and bronchial cancer, as well as malignant melanoma. The case of a patient with upper gastroenterological hemorrhage due to an ulcerated metastasis from a renal cell carcinoma is presented.     

Increase of large granular lymphocytes in human ejaculate containing antisperm antibodies

Using flow cytometry, we studied the expression of the CD16 antigen by lymphocytes present in human semen samples from three groups of patients: 60 fertile men attending for vasectomy, 60 sterile patients without antisperm antibodies (ASA) and 18 immunological sterile patients with ASA in their ejaculate. No significant difference was found in the concentration of leukocytes or subpopulations of these cells (monocytes, lymphocytes and granulocytes) between fertile, sterile without ASA and immunological sterile groups. However, we detected a predominance of macrophages/monocytes within the population of seminal leukocytes. No statistically significant difference was found in the absolute number of T and B lymphocytes between the three groups studied. However, a significant increase in the number of CD16+ lymphocytes was observed in the ejaculate of sterile patients with ASA as compared to the other groups. This finding might establish an important parameter in the follow-up and prognosis of patients with immunological sterility.      

北野菊黄酮类成分研究

从北野菊(Dendranthema lavandulifolium)全草中分得四个黄酮类化合物。经光谱(UV,IR,氢谱,碳谱,质谱等)方法鉴定其结构,分别为木樨草素(I),洋芹素(I),金合欢素-7-O-α-L-鼠李糖基(1→6)-β-D-葡萄糖甙(II)和金合欢素-7-O-α-L-鼠李糖基(1→6)-[2-O-乙酰基-β-D-葡萄糖基(1→2)]-β-D-葡萄糖甙(IV)。其中,I和I为首次从该植物中得到,IV为一个新化合物。     

Cytoskeletal organization and functional changes in monocytes from patients with chronic hepatitis B: relationship with viral replication

Monocytes play an important role in the initiation and regulation of the antiviral immune response. These cells have a dense framework of intermediate filaments composed of vimentin monomers. In 35 patients with chronic hepatitis B, 26 healthy controls, seven patients with acute liver damage and eight patients with inactive HBsAg-negative cirrhosis, we investigated the expression of vimentin filaments, C3b and IgGFc receptors, HLA-DR molecules and the phagocytic activity in monocytes purified from venous blood. In the same subjects, we also studied the display of CD2, CD3 and CD5 on lymphocytes. In patients with chronic hepatitis B manifesting viral replication (n = 21; Group 1), the expression of vimentin filaments and the other functional monocyte parameters were decreased, whereas in patients in the nonreplicative phase of the disease (n = 14; Group 2) and in control cases with various forms of acute liver damage or inactive HBsAg-negative cirrhosis, they were similar to those found in healthy subjects. In Group 1, there was also a selective defect in the display of CD3 on lymphocytes. The expression of this molecule correlated with the functional state of monocytes. In three patients with chronic hepatitis B that changed from the replicative to the nonreplicative phase of the disease, the expression of vimentin filaments in monocytes and of CD3 on lymphocytes increased to normal levels. On the other hand, the incubation of patients' monocytes with gamma-interferon corrected the diminished expression of vimentin filaments and the other decreased functional parameters.(ABSTRACT TRUNCATED AT 250 WORDS)     

胃复安引起过敏性荨麻疹1例

1　病例报告　男 ,2 4岁 ,因晨起饮冷开水后 ,阵发性上腹痛伴恶心 1h,呕吐 1次来就诊 ,其间无腹泻 .既往无眩晕及肝肾疾病史 .查体 :T36 .8℃ ,HR79次· min- 1 ,BP14.1/10 .2 k Pa,一般状况可 ,咽、扁桃体不充血 ,心肺未见异常 ,腹部平坦 ,未见明显肠型及蠕波 ,左上腹深压痛 ,无肌卫及反跳收稿日期 :2 0 0 0 -0 7-2 1;　修回日期 :2 0 0 0 -0 8-2 3作者简介 :丁向清 (196 8-) ,男 (汉族 ) ,湖北省应城市人 .主治医师 .Tel.(0 431) 79710 16 Ext. 6 6 5 12痛 ,肝脾未及 ,肠鸣音略亢进无气过水声 ,肾区无叩痛 ,胸腹透未见异常 ,WBC 5 .3…     

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor

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Stillbirth rate and associated risk factors among 869 750 Latin American hospital births 1982-1986.

Fetal death is essential to evaluate perinatal outcome. Accurate stillbirth rate however is difficult to obtain; this is especially so in developing countries. Current information was obtained through a clinical-epidemiological study, ECLAMC, during the 1982-1986 period for a total sample of 869 750 births in 102 hospitals belonging to 11 Latin American countries. The overall stillbirth rate was 2.0%, the highest being in Bolivian (4.4%) and the lowest in Chilean hospitals (0.9%). In all countries there was a high mortality rate among male fetuses. The incidence of stillbirth in multiple pregnancies almost doubled that for singletons. A steady increase with increasing maternal age was observed. The proportion of all births in mothers 35 years of age or older was 10.1%, while the stillbirth proportion among all stillbirths in the same maternal age group was 18.8%. As expected, a higher fetal mortality rate (10.7%) was found in the low birthweight group (less than or equal to 2500 g) than in the group with birthweight greater than 2500 g (0.6%). One out of ten births occurred in the former group. A striking difference was observed in the stillbirth rate between hospitals with free obstetrical care (2.5%) and those in which any type of payment was required (1.4%). Although socioeconomical factors are probably the main factors responsible for fetal death, increased maternal age and a high incidence of low birthweight also contributed greatly to fetal mortality. These risk factors for fetal mortality should be the target of public health actions in these countries.     

Injecting drug use as risk factor for visceral leishmaniasis in AIDS patients

In Madrid Region 6652 AIDS cases were diagnosed between 1982 and 1993. Visceral leishmaniasis (VL) was present in 166 (2.49%). VL frequency among injecting drug users proved higher than that for the other transmission categories (relative risk 2.57; 95% confidence interval 1.64–4.01). This could point to an alternative Leishmania transmission route via needle sharing.