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71.
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Karmele Valencia Marta Martín-Fernández Carolina Zandueta Cristina Ormazábal Susana Martínez-Canarias Eva Bandrés Concepción de la Piedra Fernando Lecanda 《BONE》2013,52(1):532-539
Recent evidence suggests that miRNAs could be used as serum markers in a variety of normal and pathological conditions. In this study, we aimed to identify novel miRNAs associated with skeletal metastatic disease in a preclinical model of lung cancer bone metastasis. We assessed the validity of these miRNAs as reliable serum biochemical markers to monitor the extent of disease and response to treatment in comparison to imaging techniques and standard biochemical markers of bone turnover. Using a murine model of human lung cancer bone metastasis after zoledronic acid (ZA) treatment, PINP (procollagen I amino-terminal propeptide) was the only marker that exhibited a strong correlation with osteolytic lesions and tumor burden at early and late stages of bone colonization. In contrast, BGP (osteocalcin) and CTX (carboxyterminal telopeptide) demonstrated a strong correlation only at late stages. We performed qPCR based screening of a panel of 380 human miRNAs and quantified bone metastatic burden using micro-CT scans, X-rays and bioluminescence imaging. Interestingly, levels of miR-326 strongly associated with tumor burden and PINP in vehicle-treated animals, whereas no association was found in ZA-treated animals. Only miR-193 was associated with biochemical markers PINP, BGP and CTX in ZA-treated animals. Consistently, miR-326 and PINP demonstrated a strong correlation with tumor burden. Our findings, taken together, indicate that miR-326 could potentially serve as a novel biochemical marker for monitoring bone metastatic progression. 相似文献
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Hantaan virus was discovered in Korea during the 1970s while other similar viruses were later reported in Asia and Europe. There was no information about hantavirus human infection in the Americas until 1993 when an outbreak was described in the United States. This event promoted new studies to find hantaviruses in the Americas. At first, many studies were conducted in Brazil, Argentina, Chile, Uruguay and Paraguay, while other Latin American countries began to report the presence of these agents towards the end of the 20th century. More than 30 hantaviruses have been reported in the Western Hemisphere with more frequent cases registered in the southern cone (Argentina, Chile, Uruguay, Paraguay, Bolivia and Brazil). However there was an important outbreak in 2000 in Panama and some rare events have been described in Peru, Venezuela and French Guiana. Since hantaviruses have only recently emerged as a potential threat in the tropical zones of the Americas, this review compiles recent hantavirus reports in Central America, the Caribbean islands and the northern region of South America. These studies have generated the discovery of new hantaviruses and could help to anticipate the presentation of possible future outbreaks in the region. 相似文献
75.
Fernanda Neves de Carvalho Carolina Toniolo Zenatti Danila Cassia Reis Santana Juliana Maria da Silva Juliane Cristina Oliveira dos As Katia Kisielow dos Anjos Jessica Sigari Cassia de Lima Santos Marcelle Guerra Olivia Pereira Barros Tomaz Cochemore Roberto Camargo Narciso Mario Lucio Baptista Filho 《The Brazilian journal of infectious diseases》2018
76.
The impact of preapheresis white blood cell count on autologous peripheral blood stem cell collection efficiency and HSC infusion side effect rate
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Barceló Bernardino Gomila Isabel Rotolo Maria Concetta Marchei Emilia Kyriakou Chrystalla Pichini Simona Roset Carolina Elorza Miguel Ángel Busardò Francesco Paolo 《International journal of legal medicine》2017,131(6):1543-1553
International Journal of Legal Medicine - The acute and chronic toxicity of several new psychoactive substances (NPS) is unknown, and only little information is available on the pharmacology and... 相似文献
79.
Jayme de Oliveira Filho Ana Carolina Franco Tebet Anna Rita Ferrante Mitidieri de Oliveira Kassila Nasser 《Anais brasileiros de dermatologia》2014,89(3):501-503
Ewing sarcoma is a primitive neuroectodermal tumor rarely occurs in the skin and
sobcutaneous tissues. Generally Ewing''s sarcoma is a primary bone tumor, but
when present in soft tissues it characterizes an extremely uncommon clinical
picture. It usually involves the deep subcutaneous tissue or muscles, and more
rarely occurs like a primary skin cancer. Most patients are white, women, and in
the second decade of life. The clinical features are a superficial mass, in
average measuring 2-3 cm, of soft consistency, freely mobile and sometimes
painful. The more affected locations are upper and lower extremities, trunk,
head, neck or multiple lesions. The presence of metastases is very rare. 相似文献
80.
Carolina Degen Meotti Glaura Plates Letycia Lopes Chagas Nogueira Renata Anselme da Silva Karoline Silva Paolini Elias Moreira Nunes Fred Bernardes Filho 《Anais brasileiros de dermatologia》2014,89(2):332-333
Cutaneous larva migrans is a pruritic dermatitis due to the inoculation of helminths
larvae in the skin, and it often occurs in children in tropical and subtropical
areas. The authors describe an atypical case of cutaneous larva migrans in a 11
year-old child with scalp involvement, an unusual topography for this lesion. 相似文献