全文获取类型
收费全文 | 20681篇 |
免费 | 1374篇 |
国内免费 | 73篇 |
专业分类
耳鼻咽喉 | 250篇 |
儿科学 | 774篇 |
妇产科学 | 584篇 |
基础医学 | 2379篇 |
口腔科学 | 252篇 |
临床医学 | 3526篇 |
内科学 | 3603篇 |
皮肤病学 | 211篇 |
神经病学 | 1964篇 |
特种医学 | 316篇 |
外科学 | 1660篇 |
综合类 | 213篇 |
一般理论 | 85篇 |
预防医学 | 3172篇 |
眼科学 | 713篇 |
药学 | 1042篇 |
中国医学 | 11篇 |
肿瘤学 | 1373篇 |
出版年
2023年 | 76篇 |
2022年 | 119篇 |
2021年 | 298篇 |
2020年 | 216篇 |
2019年 | 360篇 |
2018年 | 409篇 |
2017年 | 322篇 |
2016年 | 373篇 |
2015年 | 449篇 |
2014年 | 599篇 |
2013年 | 1030篇 |
2012年 | 1419篇 |
2011年 | 1488篇 |
2010年 | 820篇 |
2009年 | 705篇 |
2008年 | 1327篇 |
2007年 | 1538篇 |
2006年 | 1494篇 |
2005年 | 1494篇 |
2004年 | 1447篇 |
2003年 | 1327篇 |
2002年 | 1289篇 |
2001年 | 197篇 |
2000年 | 139篇 |
1999年 | 200篇 |
1998年 | 281篇 |
1997年 | 225篇 |
1996年 | 192篇 |
1995年 | 167篇 |
1994年 | 182篇 |
1993年 | 150篇 |
1992年 | 97篇 |
1991年 | 121篇 |
1990年 | 94篇 |
1989年 | 83篇 |
1988年 | 79篇 |
1987年 | 79篇 |
1986年 | 80篇 |
1985年 | 81篇 |
1984年 | 100篇 |
1983年 | 101篇 |
1982年 | 121篇 |
1981年 | 125篇 |
1980年 | 111篇 |
1979年 | 67篇 |
1978年 | 63篇 |
1977年 | 62篇 |
1976年 | 48篇 |
1975年 | 51篇 |
1973年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 390 毫秒
1.
Hannah C. Nordhues Anjali Bhagra Natya N. Stroud Jennifer A. Vencill Carol L. Kuhle 《Mayo Clinic proceedings. Mayo Clinic》2021,96(7):1907-1920
The coronavirus disease 2019 (COVID-19) pandemic has rapidly created widespread impacts on global health and the economy. Data suggest that women are less susceptible to severe illness. However, sex-disaggregated data are incomplete, leaving room for misinterpretation, and focusing only on biologic sex underestimates the gendered impact of the pandemic on women. This narrative review summarizes what is known about gender disparities during the COVID-19 pandemic and the economic, domestic, and health burdens along with overlapping vulnerabilities related to the pandemic. In addition, this review outlines recommended strategies that advocacy groups, community leaders, and policymakers should implement to mitigate the widening gender disparities related to COVID-19. 相似文献
2.
3.
Osric A. Forrest Daniel M. Chopyk Yael Gernez Milton R. Brown Carol K. Conrad Richard B. Moss Vin Tangpricha Limin Peng Rabindra Tirouvanziam 《Journal of cystic fibrosis》2019,18(1):64-70
Background
Resistin is an immunometabolic mediator that is elevated in several inflammatory disorders. A ligand for Toll-like receptor 4, resistin modulates the recruitment and activation of myeloid cells, notably neutrophils. Neutrophils are major drivers of cystic fibrosis (CF) lung disease, in part due to the release of human neutrophil elastase- and myeloperoxidase-rich primary granules, leading to tissue damage. Here we assessed the relationship of resistin to CF lung disease.Methods
Resistin levels were measured in plasma and sputum from three retrospective CF cohorts spanning a wide range of disease. We also assessed the ability of neutrophils to secrete resistin upon activation in vitro. Finally, we constructed a multivariate model assessing the relationship between resistin levels and lung function.Results
Plasma resistin levels were only marginally higher in CF than in healthy control subjects. By contrast, sputum resistin levels were very high in CF, reaching 50–100 fold higher levels than in plasma. Among CF patients, higher plasma resistin levels were associated with allergic bronchopulmonary aspergillosis, and higher sputum resistin levels were associated with CF-related diabetes. Mechanistically, in vitro release of neutrophil primary granules was concomitant with resistin secretion. Overall, sputum resistin levels were negatively correlated with CF lung function, independently of other variables (age, sex, and genotype).Conclusions
Our data establish relationships between resistin levels in the plasma and sputum of CF patients that correlate with disease status, and identify resistin as a novel mechanistic link between neutrophilic inflammation and lung disease in CF. 相似文献4.
5.
Harinakshi Sanikini David C. Muller Marisa Sophiea Sabina Rinaldi Antonio Agudo Eric J. Duell Elisabete Weiderpass Kim Overvad Anne Tjønneland Jytte Halkjær Marie-Christine Boutron-Ruault Franck Carbonnel Iris Cervenka Heiner Boeing Rudolf Kaaks Tilman Kühn Antonia Trichopoulou Georgia Martimianaki Anna Karakatsani Valeria Pala Domenico Palli Amalia Mattiello Rosario Tumino Carlotta Sacerdote Guri Skeie Charlotta Rylander María-Dolores Chirlaque López Maria-Jose Sánchez Eva Ardanaz Sara Regnér Tanja Stocks Bas Bueno-de-Mesquita Roel C.H. Vermeulen Dagfinn Aune Tammy Y.N. Tong Nathalie Kliemann Neil Murphy Marc Chadeau-Hyam Marc J. Gunter Amanda J. Cross 《International journal of cancer. Journal international du cancer》2020,146(4):929-942
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI ≥30 vs. 18.5–25 kg/m2: HR = 1.94, 95% CI: 1.25–3.03) and women (HR = 2.66, 95% CI: 1.15–6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99–6.06 for WHR >0.96 vs. <0.91; HR = 2.67, 95% CI: 1.52–4.72 for WC >98 vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35–14.33 for WHR >0.82 vs. <0.76; HR = 5.67, 95% CI: 1.76–18.26 for WC >84 vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14–0.99; >2 vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32–0.91; >26 vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04–3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers. 相似文献
6.
7.
Fluid role boundaries: exploring the contribution of the advanced nurse practitioner to multi‐professional palliative care 下载免费PDF全文
8.
9.
10.
Jerry A. Shields Ralph C. Eagle Jr Carol L Shields Brian P. Marr 李学民 《美国医学会眼科杂志(中文版)》2006,18(1):33-39
众所周知,视网膜星形细胞瘤常伴有结节性硬化的表现。视网膜星形细胞瘤一般是发生在视网膜神经纤维层的无蒂轻度隆起性病变。临床上可以是单侧发生,也可以是双侧发生。可以单个病灶,也可以多个病灶。可以是透明的,也可以是不透明的。可以有钙化,也可以没有钙化。视网膜星形细胞瘤相对固定的伴有眼内结节性硬化,很少表现为浸润性增长。在很少的情况下视网膜星形细胞瘤可以表现出浸润性增长,造成局部严重并发症。 相似文献