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991.
Arwa Kurabi Kwang Pak Adam S. DeConde Allen F. Ryan Carol H. Yan 《Head and neck pathology》2022,16(2):607
Viral infections have already been implicated with otitis media and sudden sensorineural hearing loss. However, the pathophysiology of COVID-19 as it relates to otologic disorders is not well-defined. With the spread of SARS-CoV-2, it is important to evaluate its colonization of middle ear mucosa. Middle ear and nasal tissue samples for quantitative RT-PCR and histologic evaluations were obtained from post-mortem COVID-19 patients and non-diseased control patients. Here we present evidence that SARS-CoV-2 colonizes the middle ear epithelium and co-localizes with the primary viral receptor, angiotensin-converting enzyme 2 (ACE2). Both middle ear and nasal epithelial cells show relatively high expression of ACE2, required for SARS-CoV-2 entry. The epithelial cell adhesion molecule (EpCAM) was use as a biomarker of epithelia. Furthermore, we found that the viral load in the middle ear is lower than that present in the nasal cavity. 相似文献
992.
Emrah Aydn Heather Nolan Jose Luis Peir Patricia Burns Beth Rymeski Foong-Yen Lim 《Pediatric surgery international》2020,36(4):485-491
Primary closure is often inadequate for large congenital diaphragmatic hernia (CDH) and necessitates repair by prosthetic patch or autologous muscle flap. Our aim was to evaluate outcomes of open patch versus flap repair, specifically diaphragmatic reherniation. A retrospective review (IRB #2017-6361) was performed on all CDH patients repaired from 2005 to 2016 at a single academic children’s hospital. Patients were excluded from final analysis if they had primary or minimally invasive repair, expired, or were lost to follow-up. Of 171 patients, 151 (88.3%) survived to discharge, 9 expired after discharge and 11 were lost to follow up, leaving 131 (86.8%) long-term survivors. Median follow-up was 5 years. Open repair was performed in 119 (90.8%) of which 28 (23.5%) underwent primary repair, 34 (28.6%) patch repair, and 57 (47.9%) flap repair. Overall, 6/119 (5%) patients reherniated, 1/28 (3.6%) in the primary group, 3/34 (8.8%) in the patch group, and 2/57 (3.5%) in the flap group. Comparing prosthetic patch to muscle flap repair, there was no significant difference in the number of patients who recurred nor time to reherniation (3 vs. 2, p = 0.295; 5.5 ± 0.00 months vs. 53.75 ± 71.06 months, p = 0.288). One patient in the patch group recurred twice. Both muscle flap and patch repair of large CDH are feasible and durable with a relatively low risk of recurrence. 相似文献
993.
Miyake Hiromu Lee Carol Chusilp Sinobol Bhalla Manvi Li Bo Pitino Michael Seo Shogo OConnor Deborah L. Pierro Agostino 《Pediatric surgery international》2020,36(2):155-163
Pediatric Surgery International - Human breast milk (HBM), which contains an abundant supply of exosomes, is known to prevent necrotizing enterocolitis (NEC). Preterm infants are commonly given... 相似文献
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Cranial nerve outcomes in regionally recurrent head & neck melanoma after sentinel lymph node biopsy
997.
Umberto Volpe Hania Amin Olatunde O. Ayinde Alistair Burns Wai Chi Chan Renaud David Slavica Djukic Dejanovic Gorica Djokic Defne Eraslan Giulia A.L. Fischer Patricia Gracia-García Syed Usman Hamdani Changsu Han Hussain Jafri Roy A. Kallivayalil Roderick Leonard Kriekaart Ee Heok Kua Linda C.W. Lam Dusica Lecic-Tosevski Iracema Leroi Antonio Lobo Adriana Mihai Fareed Aslam Minhas Heena Mistry Afolakemi T. Ogundele Marcel G.M. Olde Rikkert Javier Olivera Claudia Palumbo Angela Parker Bojana Pejuskovic Florian Riese Philippe Robert Maya Semrau Gabriela Stoppe Sanu Sudhakar Andreea Raluca Tirintica Sehrish Tofique Chris Tsoi Lucas Wolski Irem Yalug Huali Wang Xin Yu Norman Sartorius 《International journal of geriatric psychiatry》2020,35(2):163-173
998.
Nicolas Farina Ben Hicks Kate Baxter Yvonne Birks Carol Brayne Margaret Dangoor Josie Dixon Peter R. Harris Bo Hu Martin Knapp Eleanor Miles Rotem Perach Sanna Read Louise Robinson Jennifer Rusted Rob Stewart Alan Thomas Raphael Wittenberg Sube Banerjee 《International journal of geriatric psychiatry》2020,35(3):290-301
999.
Riccardo Zuccarino Valeria Prada Isabella Moroni Emanuela Pagliano Maria Foscan Giulia Robbiano Chiara Pisciotta Kayla Cornett Rosemary Shy Angelo Schenone Davide Pareyson Michael Shy Joshua Burns 《Journal of the peripheral nervous system : JPNS》2020,25(2):138-142
The Charcot‐Marie‐Tooth disease Pediatric Scale (CMTPedS) is a Rasch‐built clinical outcome measure of disease severity. It is valid, reliable, and responsive to change for children and adolescents aged 3 to 20 years. The aim of this study was to translate and validate an Italian version of the CMTPedS using a validated framework of transcultural adaptation. The CMTPedS (Italian) was translated and culturally adapted from source into Italian by two experts in CMT with good English language proficiency. The two translations were reviewed by a panel of experts in CMT. The agreed provisional version was back translated into English by a professional translator. The definitive Italian version was developed during a consensus teleconference by the same panel. CMT patients were assessed with the final version of the outcome measure and a subset had a second assessment after 2 weeks to evaluate test‐retest reliability. Seventeen patients with CMT aged 5 to 20 years (eight female) were evaluated with the CMTPedS (Italian), and test‐retest was performed in three patients. The CMTPedS (Italian) showed a high test‐retest reliability. No patient had difficulty in completing the scale. The instructions for the different items were clearly understood by clinicians and therefore the administration of the outcome measure was straight forward and easily understood by the children assessed. The CMTPedS (Italian) will be used for clinical follow‐up and in clinical research studies in the Italian population. The data is fully comparable to that obtained from the English language version. 相似文献
1000.
Maria M. Rubinstein MD David M. Hyman MD Imogen Caird BA Helen Won MS Krysten Soldan BSN Kenneth Seier MS Alexia Iasonos PhD William P. Tew MD Roisin E. O’Cearbhaill MD Rachel N. Grisham MD Martee L. Hensley MD Tiffany Troso-Sandoval MD Paul Sabbatini MD Joyce Guillen BS S. Duygu Selcuklu PhD Catherine Zimel BS Jean Torrisi MD Carol Aghajanian MD Vicky Makker MD 《Cancer》2020,126(6):1274-1282