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排序方式: 共有120条查询结果,搜索用时 476 毫秒
101.
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Specchia G Pastore D Mestice A Liso A Carluccio P Leo M Casanova M Sibilla S Giannoccaro M Liso V 《Acta haematologica》2006,116(4):229-237
This study aimed to identify which subset of CD34+ cells might be the most predictive of early and long-term hematopoietic recovery following autologous peripheral blood stem cell (PBSC) transplantation (PBSCT) in adult acute myeloid leukemia (AML) patients. The relationships between the number of 'mature' subsets of CD34+ cells (CD34+/CD33+, CD34+/CD38+, CD34+/DR+ and CD34+/CD90-) and 'immature' subsets of CD34+ cells (CD34+/CD33-, CD34+/CD38-, CD34+/DR- and CD34+/CD90+) and early and long-term hemoglobin, neutrophil and platelet counts were studied in a homogeneous series (for disease, pre-transplant chemotherapy, mobilization chemotherapy, conditioning regimen) of 26 AML patients after autologous PBSCT. Cell counts were performed before and after cryopreservation, but only after thawing were the cell counts used for correlation with early and long-term engraftment. The number of CD34+/CD38- cells infused correlated with the neutrophil (r = 0.88, p < 0.005) and platelet counts (r = 0.67, p < 0.05) at 12 months after PBSCT. This correlation was better than that for the total CD34+ cell dose at 12 months (r = 0.36, p = 0.09 for neutrophil count and r = 0.48, p = 0.06 for platelets count). The number of CD34+/CD90+ cells was also correlated with the platelet counts at 6 (r = 0.70, p < 0.05) and 12 months (r = 0.80, p = 0.005) after PBSCT. This correlation was better than the total dose of CD34+ cells at 6 (r = 0.31, p = 0.3) and 12 months (r = 0.48, p = 0.06) for the platelet counts. CD34+ subset analysis suggests that for early engraftment the total number of CD34+ cells infused is more strongly correlated than the CD34+ subsets, whereas the CD34+/CD38- and CD34+/CD90+ subsets may be associated with sustained long-term neutrophil and platelet engraftment. These findings may help to predict the repopulating capacity of PBSCs in AML patients after autologous PBSCT, especially when a relatively low number of CD34+ cells is infused. 相似文献
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Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects. 总被引:2,自引:0,他引:2
Diego Vanuzzo Lorenza Pilotto Rossana Lombardi Guido Lazzerini Marisa Carluccio Silvia Diviacco Franco Quadrifoglio Giorgia Danek Dario Gregori Paolo Fioretti Marco Cattaneo Raffaele De Caterina 《European heart journal》2007,28(4):484-491
AIMS: The contribution of homocysteine and group B vitamins in determining cardiovascular risk is debated. We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study. METHODS AND RESULTS: Within a cohort of 1021 healthy subjects (490 men and 531 women) recruited in 1987, 66 first-ever coronary and 43 first-ever cerebrovascular events were recorded at a 12-year follow-up (cases, n=109). A total of 109 control subjects (remaining free from events) were matched with cases according to age, sex, smoking, hypertension, dyslipidaemia, and body mass index. Serum samples obtained in 1987 at baseline were used to measure tHcy, folate, and vitamins B12 and B6, as well as C-reactive protein plasma concentrations. We found a significant graded association between tHcy levels and the risk of coronary and cerebrovascular events [odds ratio (OR) for uppermost vs. lowermost quartile=1.34, 95% CI 1.01-1.76)]. Folate and vitamin B12 did not significantly differ between cases and controls, but were negatively (P<0.01) correlated with tHcy. Vitamin B6 did not correlate with tHcy levels, but differed significantly between cases and controls: for subjects in the uppermost quartile vs. the lowermost quartile of vitamin B6, OR=0.69 (95% CI 0.49-0.98). For subjects in the lowermost quartile of vitamin B6 and the uppermost quartile of tHcy, OR=17.50 (95% CI 1.97, 155.59). Cases and controls were not different as to C-reactive protein. CONCLUSION: tHcy and plasma vitamin B6 are long-term independent risk factors for coronary and cerebrovascular events. 相似文献
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Serena Delbue Deliu-Victor Matei Camilla Carloni Valentina Pecchenini Silvia Carluccio Sonia Villani Valeria Tringali Antonio Brescia Pasquale Ferrante 《Medical microbiology and immunology》2013,202(6):425-430
Prostate cancer (PCA) is the most frequent cancer in men. Exposure to infectious agents has been reported to have a putative role in tumorigenesis. Among the infectious agents, convincing evidence has been accumulated about the human polyomavirus BK (BKV). Tissue fresh specimens, serum, and urine samples were collected from 124 consecutive patients, 56 with PCA and 68 with benign prostatic hyperplasia (BPH). Quantitative PCR assays were used to assess the presence of BKV and JC virus (JCV) genomes. BKV-positive tissue specimens were found in 32.1 and 22.1 % of PCA and BPH patients, respectively; in PCA group the number of positive BKV specimens/patients was significantly higher than in BPH group (3.06 vs. 1.73, p = 0.02). JCV genome was found in the biopsies collected from 28.1 and 24.2 % of PCA and BPH patients, respectively, with no significant difference in the rate of JCV specimens/patients between PCA and BPH groups. Our results support the putative causal association between BKV genome and PCA. Further studies are required to demonstrate the direct pathogenetic role of BKV in the PCA occurrence and progression in order to clear the tempting way of vaccine prophylaxis. 相似文献
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G. Barzoi S. Carluccio B. Bianchi S. Vassia G. Colucci G. L. Mangiante 《HPB surgery》2000,11(6):393-399
Anaesthesia and surgical procedures lead to a
reduction of intestinal motility, and opioids may
produce a postoperative ileus, that might delay
postoperative feeding. The aim of this prospective
randomised study is to test whether or not different
kinds of epidural analgesia (Group A: morphine 0.00
17 mg/kg/h and bupivacaine 0.125% – 0.058 mg/kg/h;
Group B: morphine alone 0.035mg/kg/12h in the
postoperative period) allow earlier postoperative
enteral feeding, enhance intestinal motility a passage
of flatus and help avoid complications, such
as nausea, vomiting, ileus, diarrhoea, pneumonia or
other infective diseases. We included in the study 60
patients (28 males and 32 females) with a mean age
of 61.2 years (range 50–70) and with an ASA score of
2 or 3. All patients had hepato–biliary-pancreatic
neoplasm and were candidates for major surgery.
We compared two different pharmacological approaches,
i.e., morphine plus bupivacaine (30 patients,
Group A)versus morphine alone (30 patients,
Group B). Each medication was administered by
means of a thoracic epidural catheter for the control
of postoperative pain. In the postoperative course
we recorded every 6 hours peristaltic activity. We
also noted morbidity (pneumonia, wound sepsis)
and mortality. Effective peristalsis was present in
all patients in Group A within the first six postoperative
hours; in Group B, after 30 hours. Six
patients in Group A had bowel motions in the first
postoperative day, 11 in the second day, 10 in the
third day and 3 in fourth day, while in Group B none
in the first day, two in the second, 7 in the third, 15
in the fourth, and 6 in the fifth: the difference
between the two groups was significant (P<0.05
in 1st, 2nd, 4th and 5th days). Pneumonia occurred
in 2 patients of Group A, and in 10 of Group B
(P<0.05).We conclude that epidural analgesia with morphine
plus bupivacaine allowed a move rapid return
to normal gut activity and early enteral nutrition compared
with epidural analgesia with morphine alone. 相似文献