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991.
Dr. A.J. Chorao de Aguiar Chefe de Clínica Dr. H. Guimaraes Mdico Especialista Dr. A. Raposo Interno do Internato Complementar de Cardiologia M. Cerqueira Gomes R. Paula Pinto R. Gonalves Fernando Pdua Virginia Lopes Drio Reis Carlos Ribeiro Isabel Lacximy Ramiro Correia 《Journal of electrocardiology》1979,12(4):381-386
992.
Maria-Fernanda Solá-Ruiz Carolina Pérez-Martínez José-Javier Martín-del-Llano Carmen Carda-Batalla Carlos Labaig-Rueda 《Medicina oral, patología oral y cirugía bucal》2015,20(1):e88-e93
Objectives: To observe human osteoblast behavior cultured in vitro on titanium discs (Ti) in relation to surface roughness and melatonin application.
Study Design: Human osteoblasts (MG-63) were cultured on 60 Ti6Al4V discs divided into three groups: Group I: discs treated with dual acid etching; Group II dual acid etching and blasting with calcium phosphate particles; Group III (control) machined discs. Surface roughness and topography of the discs were examined with scanning electron microscope (SEM) and confocal laser scanning electron microscope( CLSM).
Osteoblast adhesion, proliferation and cell morphology were determined by means of fluorescence microscopy with Image-Pro Plus software and SEM.
Results: Group II presented the roughest discs, while the least rough were Group III. Cell adhesion was greatest in Group II. The addition of melatonin improved cell proliferation.
Conclusions: 1. Surface treatments (dual acid etching, calcium phosphate impaction) increase surface roughness in comparison with machined titanium.
2. Greater surface roughness tends to favor cell adhesion after 24-hour cell culture.
3. The addition of melatonin tends to favor osteoblast proliferation.
Key words:Osteoblasts, titanium, roughness, melatonin, dental implants, osseointegration. 相似文献
993.
994.
995.
Virginia Balouz María de los Milagros Cámara Gaspar E. Cánepa Santiago J. Carmona Romina Volcovich Nicolás Gonzalez Jaime Altcheh Fernán Agüero Carlos A. Buscaglia 《Clinical and Vaccine Immunology : CVI》2015,22(3):304-312
The trypomastigote small surface antigen (TSSA) is a mucin-like molecule from Trypanosoma cruzi, the etiological agent of Chagas disease, which displays amino acid polymorphisms in parasite isolates. TSSA expression is restricted to the surface of infective cell-derived trypomastigotes, where it functions as an adhesin and engages surface receptors on the host cell as a prerequisite for parasite internalization. Previous results have established TSSA-CL, the isoform encoded by the CL Brener clone, as an appealing candidate for use in serology-based diagnostics for Chagas disease. Here, we used a combination of peptide- and recombinant protein-based tools to map the antigenic structure of TSSA-CL at maximal resolution. Our results indicate the presence of different partially overlapping B-cell epitopes clustering in the central portion of TSSA-CL, which contains most of the polymorphisms found in parasite isolates. Based on these results, we assessed the serodiagnostic performance of a 21-amino-acid-long peptide that spans TSSA-CL major antigenic determinants, which was similar to the performance of the previously validated glutathione S-transferase (GST)-TSSA-CL fusion molecule. Furthermore, the tools developed for the antigenic characterization of the TSSA antigen were also used to explore other potential diagnostic applications of the anti-TSSA humoral response in Chagasic patients. Overall, our present results provide additional insights into the antigenic structure of TSSA-CL and support this molecule as an excellent target for molecular intervention in Chagas disease. 相似文献
996.
997.
Carlos Augusto Pinto Ventura Erasmo Sim?o da Silva Giovanni Guido Cerri Pedro Puech Le?o Adriano Tachibana Maria Cristina Chammas 《Clinics (S?o Paulo, Brazil)》2015,70(1):1-6
OBJECTIVE:
The purpose of this study was to evaluate the effectiveness of contrast-enhanced ultrasound with a second-generation contrast agent in distinguishing between occlusion and pseudo-occlusion of the cervical internal carotid artery, comparing it with that of conventional Doppler ultrasound and the gold standard, computed tomography angiography.METHOD:
Between June 2006 and June 2012, we screened 72 symptomatic vascular surgery outpatients at a public hospital. Among those patients, 78 cervical internal carotid arteries were previously classified as occluded by Doppler ultrasound (without contrast). The patients were examined again with Doppler ultrasound, as well as with contrast-enhanced ultrasound and computed tomography angiography. The diagnosis was based on the presence or absence of flow.RESULTS:
Among the 78 cervical internal carotid arteries identified as occluded by Doppler ultrasound, occlusion was confirmed by computed tomography angiography in only 57 (73.1%), compared with 59 (77.5%) for which occlusion was confirmed by contrast-enhanced ultrasound (p>0.5 vs. computed tomography angiography). Comparing contrast-enhanced ultrasound with Doppler ultrasound, we found that the proportion of cervical internal carotid arteries classified as occluded was 24.4% higher when the latter was used (p<0.001).CONCLUSIONS:
We conclude that, in making the differential diagnosis between occlusion and pseudo-occlusion of the cervical internal carotid artery, contrast-enhanced ultrasound with a second-generation contrast agent is significantly more effective than conventional Doppler ultrasound and is equally as effective as the gold standard (computed tomography angiography). Our findings suggest that contrast-enhanced ultrasound could replace computed tomography angiography in this regard. 相似文献998.
999.
Habib Bouazzi Gaetan Lesca Carlos Trujillo Mohammad Khalid Alwasiyah Arnold Munnich 《Clinical Case Reports》2015,3(7):604-609
X‐linked intellectual deficiency (XLID) is a large group of genetic disorders. MED12 gene causes syndromic and nonsyndromic forms of XLID. Only seven pathological mutations have been identified in this gene. Here, we report a novel mutation segregating with XLID phenotype. This mutation could be in favor of genotype–phenotype correlations. 相似文献