全文获取类型
收费全文 | 1534篇 |
免费 | 42篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 82篇 |
妇产科学 | 14篇 |
基础医学 | 159篇 |
口腔科学 | 11篇 |
临床医学 | 120篇 |
内科学 | 268篇 |
皮肤病学 | 71篇 |
神经病学 | 128篇 |
特种医学 | 86篇 |
外科学 | 344篇 |
综合类 | 6篇 |
预防医学 | 42篇 |
眼科学 | 4篇 |
药学 | 56篇 |
中国医学 | 3篇 |
肿瘤学 | 196篇 |
出版年
2023年 | 6篇 |
2022年 | 11篇 |
2021年 | 31篇 |
2020年 | 9篇 |
2019年 | 31篇 |
2018年 | 40篇 |
2017年 | 25篇 |
2016年 | 23篇 |
2015年 | 26篇 |
2014年 | 40篇 |
2013年 | 67篇 |
2012年 | 90篇 |
2011年 | 65篇 |
2010年 | 50篇 |
2009年 | 65篇 |
2008年 | 92篇 |
2007年 | 84篇 |
2006年 | 74篇 |
2005年 | 80篇 |
2004年 | 72篇 |
2003年 | 75篇 |
2002年 | 61篇 |
2001年 | 78篇 |
2000年 | 56篇 |
1999年 | 39篇 |
1998年 | 24篇 |
1997年 | 15篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1994年 | 11篇 |
1993年 | 7篇 |
1992年 | 33篇 |
1991年 | 18篇 |
1990年 | 21篇 |
1989年 | 16篇 |
1988年 | 18篇 |
1987年 | 16篇 |
1986年 | 16篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1981年 | 4篇 |
1979年 | 8篇 |
1974年 | 6篇 |
1972年 | 5篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1969年 | 3篇 |
1968年 | 4篇 |
1967年 | 10篇 |
排序方式: 共有1592条查询结果,搜索用时 15 毫秒
121.
122.
Alberto V. Carli Stéphane Poitras John C. Clohisy Paul E. Beaulé 《The Journal of arthroplasty》2018,33(10):3201-3205
Background
A traditional method to reduce dislocation risk following total hip arthroplasty involves prescribing postoperative precautions and ambulatory equipment to patients. The purpose of this study was to determine the prevalence of postoperative precaution and equipment use among North American arthroplasty surgeons for patients undergoing primary total hip arthroplasty.Methods
We conducted a survey of American Association of Hip and Knee Surgeons and Canadian Arthroplasty Society members using an electronic questionnaire format to determine how often precautions and equipment were prescribed, and whether their use was associated with surgical approach and other surgeon demographics.Results
Of the respondents, 44% universally prescribed precautions while 33% never prescribed precautions. Use of the posterolateral approach, surgeon experience, and larger head size use were significantly associated (P < .01) with precaution and equipment use. Direct anterior approach surgeons were significantly less likely to prescribe precautions (P < .0001) and significantly less likely to prescribe equipment (P < .0001).Conclusion
Although postoperative precautions continue to be used to some degree by the majority of members, their consumption of healthcare resources through utilization of additional care providers and purchasing of equipment, known association with reduced patient satisfaction, and lack of supporting evidence make them a target for future scrutiny. 相似文献123.
C. Iorio R. M. Lanzetti D. Lupariello A. Vadalà M. Fabbri A. Ciompi A. Ferretti A. De Carli 《Musculoskeletal surgery》2018,102(3):283-288
Purpose
Some authors consider preservation of the subscapularis tendon as one of the most important elements for a successful long-term outcome in patients operated on with open capsulorrhaphy for recurrent anterior shoulder dislocation. The purpose of this study was to evaluate whether vertical tenotomy of the subscapularis tendon might affect internal rotation strength recovery in patients operated on with open capsulorrhaphy for recurrent anterior shoulder dislocation.Methods
Ninety-six patients were retrospectively followed up at a mean of 72.5 months. They underwent clinical evaluation, Rowe and Walch–Duplay scoring scales, the Visual Analog Scale (VAS), and dynamometric measurements (side-to-side) of internal and external rotation, forward elevation, and abduction. All patients were athletes: 25% were practising risk-free sports, 44% contact sports, 14.5% sports with cocking of the arm, and 14.5% high-risk sports activities.Results
Five (5.2%) recurrences were registered, and all patients returned to pre-operative sports activity. The Rowe score was 98.12, the Walch–Duplay score 92.25, and the VAS score 0.1. Dynamometric assessment showed no significant differences (side-to-side) in internal rotation (p = 0.34), external rotation (p = 0.9), flexion (p = 0.7), and abduction (p = 0.7). Dominant arms showed better results than non-dominant arms (p < 0.01).Conclusion
Complete tenotomy of the subscapularis tendon does not seem to negatively affect internal rotation strength recovery or external rotation movement in athletes.124.
Spöhr F Arntz HR Bluhmki E Bode C Carli P Chamberlain D Danays T Poth J Skamira C Wenzel V Böttiger BW 《European journal of clinical investigation》2005,35(5):315-323
Prehospital cardiac arrest has been associated with a very poor prognosis. Acute myocardial infarction and massive pulmonary embolism are the underlying causes of out-of-hospital cardiac arrest in 50-70% of patients. Although fibrinolysis is an effective treatment strategy for both myocardial infarction and pulmonary embolism, clinical experience for this therapy performed during resuscitation has been limited owing to the anticipated risk of severe bleeding complications. The TROICA study is planned as one of the largest randomized, double-blind, placebo-controlled trials to assess the efficacy and safety of prehospital thrombolytic therapy in cardiac arrest of presumed cardiac origin. Approximately 1000 patients with cardiac arrest will be randomized at approximately 60 international study centres to receive either a weight-adjusted dose of tenecteplase or placebo after the first dose of a vasopressor. Patients can be included if they are at least 18 years, presenting with a witnessed cardiac arrest of presumed cardiac origin, and if either basic life support had started within 10 min of onset and had been performed up to 10 min or advanced life support is started within 10 min of onset of cardiac arrest. Primary endpoint of the study is the 30-day survival rate, and the coprimary endpoint is hospital admission. Secondary endpoints are the return of spontaneous circulation (ROSC), survival after 24 h, survival to hospital discharge, and neurological performance. Safety endpoints include major bleeding complications and symptomatic intracranial haemorrhage. 相似文献
125.
Dario Arnaldi Christian Cordano Fabrizio De Carli Jennifer Accardo Michela Ferrara Agnese Picco Tiziano Tamburini Andrea Brugnolo Giovanni Abbruzzese Flavio Nobili 《Neurological sciences》2016,37(2):283-288
Sleep disturbances and nocturnal disabilities are common in Parkinson’s Disease (PD). The PD sleep scale, second version (PDSS-2), has been proposed as a helpful tool for measuring sleep disorders in PD. We aimed to validate the Italian version of the PDSS-2. One hundred and twenty-three consecutive PD outpatients (76 males) were evaluated by means of PDSS-2, Epworth Sleepiness Scale, Hamilton Depression Rating Scale, Parkinson’s Disease Quality of Life Questionnaire (self-administered scales), Unified Parkinson’s Disease Rating (motor section) and Hoehn and Yahr Scales, and Mini Mental State Examination. PDSS-2 internal consistency was satisfactory (Cronbach’s α: 0.77) with significant item to total score correlation and high intra-class correlation coefficient for test–retest reliability (0.943). Total PDSS-2 score was correlated with the scores on all other clinical scales. The factor analysis identified five factors, related to five areas of nocturnal disturbances, similarly as the original PDSS-2. The five factors mainly reflected: (1) nocturnal movement-related problems, (2) quality of sleep, (3) dreaming distress, (4) fragmentation of sleep and (5) insomnia symptoms. The PDSS-2 scale has confirmed its usefulness in evaluating sleep problems in Italian PD patients. 相似文献
126.
Fabrizio De Carli MSc Paola Proserpio MD Elisa Morrone PhD Ivana Sartori MD Michele Ferrara PhD Steve Alex Gibbs MD PhD Luigi De Gennaro PhD Giorgio Lo Russo MD Lino Nobili MD PhD 《Annals of neurology》2016,79(2):326-330
When dreaming during rapid eye movement (REM) sleep, we can perform complex motor behaviors while remaining motionless. How the motor cortex behaves during this state remains unknown. Here, using intracerebral electrodes sampling the human motor cortex in pharmacoresistant epileptic patients, we report a pattern of electroencephalographic activation during REM sleep similar to that observed during the performance of a voluntary movement during wakefulness. This pattern is present during phasic REM sleep but not during tonic REM sleep, the latter resembling relaxed wakefulness. This finding may help clarify certain phenomenological aspects observed in REM sleep behavior disorder. Ann Neurol 2016;79:326–330 相似文献
127.
128.
129.
Claudio Babiloni Michela Pievani Fabrizio Vecchio Cristina Geroldi Fabrizio Eusebi Claudia Fracassi Evan Fletcher Charles De Carli Marina Boccardi Paolo Maria Rossini Giovanni B. Frisoni 《Human brain mapping》2009,30(5):1431-1443
Does impairment of cholinergic systems represent an important factor in the development of amnesic mild cognitive impairment (aMCI), as a preclinical stage of Alzheimer's disease (AD)? Here we tested the hypothesis that electroencephalographic (EEG) rhythms, known to be modulated by the cholinergic system, may be particularly affected in aMCI patients with lesions along the cholinergic white‐matter tracts. Eyes‐closed resting EEG data were recorded in 28 healthy elderly (Nold) and 57 aMCI patients. Lesions along the cholinergic white‐matter tracts were detected with fluid‐attenuated inversion recovery sequences on magnetic resonance imaging. The estimation of the cholinergic lesion was performed with a validated semi‐automatic algorithm pipeline after registration to a stereotactic template, image integration with stereotactic masks of the cholinergic tracts, and normalization to intracranial volume. The aMCI patients were divided into two groups of high (MCI Ch+; N = 29; MMSE = 26.2) and low cholinergic damage (MCI Ch?; N = 28; MMSE = 26.6). EEG rhythms of interest were delta (2–4 Hz), theta (4–8 Hz), alpha 1 (8–10.5 Hz), alpha 2 (10.5–13 Hz), beta 1 (13–20 Hz), and beta 2 (20–30 Hz). Cortical EEG generators were estimated by LORETA software. As main results, (i) power of occipital, parietal, temporal, and limbic alpha 1 sources was maximum in Nold, intermediate in MCI Ch?, and low in MCI Ch+ patients; (ii) the same trend was true in theta sources. These results are consistent with the hypothesis that damage to the cholinergic system is associated with alterations of EEG sources in aMCI subjects. Hum Brain Mapp 2009. © 2008 Wiley‐Liss, Inc. 相似文献
130.
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C 总被引:1,自引:0,他引:1
Morbiato L Carli L Johnson EA Montecucco C Molgó J Rossetto O 《The European journal of neuroscience》2007,25(9):2697-2704
Botulinum neurotoxin type A (BoNT/A) is commonly used in human therapy. This treatment may induce immunoresistance and preliminary evaluation of other botulinum neurotoxin serotypes suggested botulinum neurotoxin type C (BoNT/C) to be a good alternative to BoNT/A. Here, we have further characterized the biological activities of BoNT/C using a variety of experimental approaches. Muscle paralysis and time of recovery of mouse hind limb injected with BoNT/A or BoNT/C were assayed with the Digit Abduction Scoring assay. The extent and duration of paralysis were similar with the two toxin serotypes. Extensor digitorum longus or tibialis anterior muscles were dissected at times of complete paralysis and of complete recovery. Muscle weight and force were significantly reduced in mice injected with BoNT/A and BoNT/C, and some atrophy persisted for a long time. In BoNT/C-treated junctions, nerve terminal sprouting was prominent, indicating that the capacity to extend the field of innervation is not hampered by BoNT/C. BoNT/C induced a marked decrease in the frequency of miniature endplate potentials and in the amplitude of endplate potentials. 3,4-diaminopyridine reversed the effect of BoNT/C by increasing the amplitude of synchronized endplate potentials. The present study shows an extensive similarity in the biological activities of BoNT/A and BoNT/C, further supporting the suggestion that BoNT/C is a valid alternative to BoNT/A. 相似文献