全文获取类型
收费全文 | 10819篇 |
免费 | 555篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 137篇 |
儿科学 | 272篇 |
妇产科学 | 217篇 |
基础医学 | 1607篇 |
口腔科学 | 346篇 |
临床医学 | 1072篇 |
内科学 | 2198篇 |
皮肤病学 | 176篇 |
神经病学 | 1208篇 |
特种医学 | 178篇 |
外科学 | 941篇 |
综合类 | 39篇 |
一般理论 | 5篇 |
预防医学 | 1164篇 |
眼科学 | 106篇 |
药学 | 925篇 |
中国医学 | 57篇 |
肿瘤学 | 783篇 |
出版年
2024年 | 12篇 |
2023年 | 94篇 |
2022年 | 246篇 |
2021年 | 425篇 |
2020年 | 260篇 |
2019年 | 357篇 |
2018年 | 383篇 |
2017年 | 274篇 |
2016年 | 272篇 |
2015年 | 330篇 |
2014年 | 498篇 |
2013年 | 601篇 |
2012年 | 928篇 |
2011年 | 978篇 |
2010年 | 486篇 |
2009年 | 442篇 |
2008年 | 695篇 |
2007年 | 744篇 |
2006年 | 617篇 |
2005年 | 608篇 |
2004年 | 562篇 |
2003年 | 481篇 |
2002年 | 443篇 |
2001年 | 49篇 |
2000年 | 32篇 |
1999年 | 54篇 |
1998年 | 87篇 |
1997年 | 73篇 |
1996年 | 48篇 |
1995年 | 47篇 |
1994年 | 47篇 |
1993年 | 38篇 |
1992年 | 25篇 |
1991年 | 21篇 |
1990年 | 19篇 |
1989年 | 12篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 7篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 10篇 |
1982年 | 19篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1979年 | 8篇 |
1978年 | 6篇 |
1977年 | 3篇 |
1976年 | 6篇 |
1974年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Herbs and spices represent a possibility for the improvement of anosmia and ageusia. In this work we evaluated the role of Mediterranean aromatic herbs and spices in the salty taste perception of patients with hyposmia compared to healthy controls. To this goal, the salty taste perception in response to pure salt and different types of commercial flavored sea salt was assessed in patients with hyposmia, with or without a post-acute coronavirus syndrome, and healthy controls. Myrtle berries and leaves, a mixture of Mediterranean herbs and plants such as helichrysum, rosemary, liquorice, fennel seeds and myrtle leaves, oranges and saffron were used as salt flavoring ingredients. Differences in gustatory perception between 57 patients with hyposmia and 91 controls were evaluated considering the rate of the gustatory dimensions of pleasantness, intensity, and familiarity, using a 7-point hedonic Likert-type scale. At a dose of 0.04 g/mL, saline solutions of flavored salts, with an average 15% less NaCl, were perceived by patients with hyposmia as equally intense but less familiar than pure salt solution, with similar scores in the pleasantness dimension. Our study highlighted the central role of Mediterranean aromatic plants in the enhancement of salty perception in patients with hyposmia. 相似文献
92.
93.
Vanessa Salles Albuquerque Simone Dal Corso Daniel Pereira do Amaral Túlio Medina Dutra de Oliveira Gerson Fonseca Souza Rachel Naara Silva de Souza Ana Karolyn Menezes Nogueira Pedro Dal Lago Maria Luísa Rocha Dadalt Isadora Faraco Correa Graziella Frana Bernardelli Cipriano Fabíola Maria Ferreira Silva Raquel Rodrigues Britto Anderson Jos Carla Malaguti 《Jornal brasileiro de pneumologia》2022,48(4)
94.
95.
Sofia Pinto Teresa Correia-de-S Benedita Sampaio-Maia Carla Vasconcelos Pedro Moreira Joana Ferreira-Gomes 《Nutrients》2022,14(20)
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood, affecting ~7% of children and adolescents. Given its adverse health outcomes and high healthcare and societal costs, other treatment options beyond pharmacotherapy have been explored. Case-control studies have shown that dietary patterns may influence the risk of ADHD, and specific dietary interventions have been proposed as coadjuvant treatments in this disorder. These include nutritional supplements, gut microbiome-targeted interventions with biotics, and elimination diets. The purpose of this review is to examine which dietary patterns are most associated with ADHD and to summarize the existing evidence for the clinical use of dietary interventions. The literature showed that non-healthy dietary patterns were positively associated with ADHD, whereas healthy patterns were negatively associated. As for nutritional supplements, only vitamin D and vitamin D + magnesium appeared to improve ADHD symptoms when baseline levels of vitamin D were insufficient/deficient. Regarding biotics, evidence was only found for Lactobacillus rhamnosus GG and for multi-species probiotic supplementation. Elimination diets have scarce evidence and lead to nutritional deficiencies, so caution is advised. Overall, more robust scientific evidence is required for these dietary interventions to be implemented as part of ADHD therapy. 相似文献
96.
Thatiana Wanessa Oliveira Priscilla Perez da Silva Pereira Leonice Antunes Fonseca Luna Mares Lopes de Oliveira Dauster Souza Pereira Carla Paola Domingues Neira Ana Claudia Morais Godoy Figueiredo 《Nutrients》2022,14(22)
Information and communication technologies are part of our day-to-day life in the execution of all activities, including health care. However, it is not known how much the use of technologies can contribute to the adoption of healthy lifestyle habits. Thus, the objective of this study was to analyze whether the use of information and communication technologies contributes to weight control among adults when compared to the traditional approach method. The search was performed in November 2021 in eight electronic databases in addition to gray literature bases. The quality of the studies was assessed using the Cochrane risk of bias tool. The standardized mean difference was used for the meta-analytic measurement using the random effects model using the Dersimonian–Laid method in the Stata statistical package version 17. The body mass index of the intervention group decreased by an average of 0.56 (95% CI: −0.83; −0.30) when compared to the control group. When comparing the before and after groups, the intervention group also had a greater reduction in BMI (summarized mean: −0.83; 95% CI: −1.40; −0.26). Information and communication technologies contribute to the reduction of the body mass index in the adult population when compared to the traditional model of monitoring. Prospero registration: number 42020186340. 相似文献
97.
Gergana Mincheva Carla GimenezGarzo Paula IzquierdoAltarejos Mar MartinezGarcia Magnus Doverskog Thomas P. Blackburn Anneli Hllgren Torbjrn Bckstrm Marta Llansola Vicente Felipo 《CNS Neuroscience & Therapeutics》2022,28(11):1861
AimsHyperammonemic rats show peripheral inflammation, increased GABAergic neurotransmission and neuroinflammation in cerebellum and hippocampus which induce motor incoordination and cognitive impairment. Neuroinflammation enhances GABAergic neurotransmission in cerebellum by enhancing the TNFR1‐glutaminase‐GAT3 and TNFR1‐CCL2‐TrkB‐KCC2 pathways. Golexanolone reduces GABAA receptors potentiation by allopregnanolone. This work aimed to assess if treatment of hyperammonemic rats with golexanolone reduces peripheral inflammation and neuroinflammation and restores cognitive and motor function and to analyze underlying mechanisms.MethodsRats were treated with golexanolone and effects on peripheral inflammation, neuroinflammation, TNFR1‐glutaminase‐GAT3 and TNFR1‐CCL2‐TrkB‐KCC2 pathways, and cognitive and motor function were analyzed.ResultsHyperammonemic rats show increased TNFα and reduced IL‐10 in plasma, microglia and astrocytes activation in cerebellum and hippocampus, and impaired motor coordination and spatial and short‐term memories. Treating hyperammonemic rats with golexanolone reversed changes in peripheral inflammation, microglia and astrocytes activation and restored motor coordination and spatial and short‐term memory. This was associated with reversal of the hyperammonemia‐enhanced activation in cerebellum of the TNFR1‐glutaminase‐GAT3 and TNFR1‐CCL2‐TrkB‐KCC2 pathways.ConclusionReducing GABAA receptors activation with golexanolone reduces peripheral inflammation and neuroinflammation and improves cognitive and motor function in hyperammonemic rats. The effects identified would also occur in patients with hepatic encephalopathy and, likely, in other pathologies associated with neuroinflammation. 相似文献
98.
Floriana Mascilini Lorena Quagliozzi Francesca Moro Maria Cristina Moruzzi Valerio Gallotta Salvatore Gueli Alletti Giovanni Scambia Antonia Carla Testa Anna Fagotti 《Journal of minimally invasive gynecology》2018,25(5):848-854
Study Objective
To describe the potential role of intraoperative ultrasound (IOUS) in the detection and localization of recurrent disease in gynecologic cancer patients during minimally invasive surgery (MIS).Design
A prospective cohort study (Canadian Task Force classification II-1).Setting
A university hospital.Patients
Fifty-one gynecologic cancer patients with isolated recurrent disease.Interventions
IOUS during secondary cytoreductive surgery (SCS) by MIS.Measurements and Main Results
From November 2015 to February 2017 51 gynecologic cancer patients with isolated recurrent disease and candidates for SCS were treated by MIS. Recurrent tumor was preoperatively assessed at clinical examination, transvaginal and transabdominal sonography, and radiologic evaluation in all women. Twelve of 51 women (23.5%) needed IOUS. Type of disease was ovarian in 5 women (42%), endometrial in 4 (33%), cervical in 1 (8%), vaginal cancer in 1 (8%), and uterine sarcoma in 1 (8%). Recurrence was localized deep in the pelvis in 7 cases (58%), lymph nodes in 3 (25%), and extraperitoneal in 2 cases (17%). Recurrence was dimmed in the surgical field, due to either presence of adherences, deep anatomic position, small size, and/or lack of tactile feeling. IOUS was able to identify the lesions in all women, allowing MIS (83% laparoscopy and 17% robotic) complete cytoreduction, with no conversion to laparotomy. Median operative time was 150 minutes (range, 77–280). No intraoperative/postoperative complications occurred. Histologic examination confirmed the presence of recurrence in 11 of 12 cases (92%), whereas the remaining case showed inflammatory tissue. With a median follow-up time of 15 months (range, 6–19), all patients except 2 were still alive.Conclusions
About 1 of 4 patients (25%) with single gynecologic cancer recurrence needs IOUS to benefit from MIS for complete secondary cytoreduction. 相似文献99.
Elma Izze da Silva Magalhes Bianca Rodrigues de Oliveira Lívia Carolina Sobrinho Rudakoff Vitria Abreu de Carvalho Poliana Cristina de Almeida Fonseca Viola Soraia Pinheiro Machado Arruda Carolina Abreu de Carvalho Carla Cristine Nascimento da Silva Coelho Maylla Luanna Barbosa Martins Bragana Heloisa Bettiol Marco Antnio Barbieri Viviane Cunha Cardoso Alcione Miranda dos Santos Renata Bertazzi Levy Antnio Augusto Moura da Silva 《Nutrients》2022,14(15)
Longitudinal studies evaluating the relationship between UPF consumption and the incidence of Metabolic Syndrome (MetS) and its components are still scarce. This study aimed to evaluate the effect of UPF consumption on the incidence of MetS and its components in adults. A prospective study was conducted with 896 participants from the 1978/79 Ribeirão Preto cohort, São Paulo, Brazil. UPF consumption was evaluated in %kcal and %g at ages 23–25 years. Incidence of MetS and its components were estimated at ages 37–39 years, according to the Joint Interim Statement criteria. Poisson regression was used to assess associations, and interactions with sex were investigated. UPF consumption had no association with MetS (%kcal Adjusted PR: 1.00; 95% CI: 0.99–1.01; %g Adjusted PR: 1.00; 95% CI: 0.99–1.01). However, women with higher UPF consumption, in %kcal and %g, had a higher risk of abdominal obesity (%kcal: p = 0.030; %g: p = 0.003); and women with higher UPF consumption, in %g, had a higher risk of low HDL-cholesterol (p = 0.041). For the other components of MetS, no significant associations were observed in either sex. These findings suggest evidence of no association between UPF consumption and MetS; however, consumption of UPF was associated with increased WC and low HDL-c, but only in women. 相似文献
100.
Association between CFH,CFB, ARMS2, SERPINF1, VEGFR1 and VEGF polymorphisms and anatomical and functional response to ranibizumab treatment in neovascular age‐related macular degeneration 下载免费PDF全文